Sirtuin
Las sirtuinas son una familia de desacetilasas dependientes de NAD+ que desempeñan un papel crucial en la regulación de procesos celulares como la reparación del ADN, el envejecimiento, el metabolismo y la resistencia al estrés. Las sirtuinas influyen en la reparación del ADN desacetilando proteínas involucradas en las vías de reparación, modulando así su actividad. Los inhibidores y activadores de sirtuinas son herramientas valiosas en la investigación sobre el envejecimiento, el cáncer y las enfermedades metabólicas, donde la regulación de la reparación del ADN y la longevidad celular es de interés. En CymitQuimica, ofrecemos una gama de moduladores de sirtuinas de alta calidad para apoyar su investigación en reparación del ADN, envejecimiento celular y regulación metabólica.
Se han encontrado 95 productos para "Sirtuin".
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Nicotinamide riboside
CAS:Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-Fórmula:C11H15N2O5Pureza:99.58% - 99.89%Forma y color:White SolidPeso molecular:255.25Resveratrol
CAS:Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.Fórmula:C14H12O3Pureza:99.82% - 99.96%Forma y color:SolidPeso molecular:228.2433MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Fórmula:C33H38N4O8Pureza:98.56% - 99.90%Forma y color:Yellow SolidPeso molecular:618.68Ref: TM-T11962
1mg50,00€2mg71,00€5mg105,00€10mg170,00€25mg268,00€50mg423,00€100mg685,00€500mg1.378,00€SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Fórmula:C15H21N5O3S2Pureza:98.26%Forma y color:SolidPeso molecular:383.49Ref: TM-T12919
1mg92,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg344,00€25mg587,00€50mg803,00€100mg1.099,00€200mg1.468,00€SIRT3 activator 1
SIRT3 Activator 1 (Compound 5v) is a selective activator of SIRT3. It enhances the expression of SIRT3, leading to upregulation of SOD2 and OPA1. This activity effectively mitigates mitochondrial dysfunction, alleviates oxidative stress, and maintains the vitality of cardiac myocytes. SIRT3 Activator 1 is useful in the study of cardiovascular diseases.Fórmula:C32H41N2NaO5Forma y color:SolidPeso molecular:556.67WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Fórmula:C25H21N5O2SPureza:99.33%Forma y color:SolidPeso molecular:455.53MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Fórmula:C22H19N3OSPureza:99.99%Forma y color:SolidPeso molecular:373.47Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Fórmula:C20H15N3O2SPureza:99.32%Forma y color:SolidPeso molecular:361.417Sirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Fórmula:C21H20N4O3S2Pureza:98%Forma y color:SolidPeso molecular:440.54SIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Fórmula:C55H91N9O15SForma y color:SolidPeso molecular:1150.43SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Fórmula:C14H16N2OPureza:99.58%Forma y color:SolidPeso molecular:228.29Ref: TM-T9648
1mg92,00€5mg192,00€1mL*10mM (DMSO)195,00€10mg295,00€25mg505,00€50mg708,00€100mg964,00€200mg1.288,00€SIRT2-IN-12
SIRT2-IN-12 (Compound 3) is a SIRT2 inhibitor with an IC50 value of 50 μM.Fórmula:C23H21Cl2NO3Forma y color:SolidPeso molecular:429.08985SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Forma y color:Odour SolidEt-29
CAS:Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.Fórmula:C34H46N6O6SPureza:99.52%Forma y color:White SolidPeso molecular:666.83Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Fórmula:C19H15N3O2SPureza:99.67%Forma y color:Yellow SolidPeso molecular:349.406SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Fórmula:C22H25ClN8O2SPureza:99.56%Forma y color:SolidPeso molecular:501Z26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Fórmula:C17H15FN2OPureza:99.54%Forma y color:White SolidPeso molecular:282.3122SIRT6 activator 3
SIRT6 activator3 (Compound 24) is a SIRT6 activator with an EC50 of 5 μM. It demonstrates histone deacetylation activity and is applicable in cancer research.SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Fórmula:C24H29ClN8O4SPureza:98.68%Forma y color:SolidPeso molecular:561.06HD-800
CAS:HD-800 is a highly selective SIRT2 inhibitor; IC50 37 nM; increases tubulin acetylation; regulates mitosis; cancer and neuroprotection research tool.Fórmula:C15H15N3O2Peso molecular:269.3
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