Alquilación de ADN
La alquilación del ADN implica la adición de grupos alquilo a la molécula de ADN, lo que lleva a la formación de lesiones que pueden interferir con la replicación y transcripción del ADN. Los agentes alquilantes del ADN se utilizan comúnmente en la quimioterapia contra el cáncer para inducir daños en el ADN de células que se dividen rápidamente. Sin embargo, las células tienen mecanismos para reparar estas lesiones, y los inhibidores de las vías de reparación de la alquilación del ADN pueden mejorar la eficacia de los agentes alquilantes. En CymitQuimica, ofrecemos una selección de reactivos e inhibidores de la alquilación del ADN de alta calidad para apoyar su investigación en daño al ADN, mecanismos de reparación y terapia contra el cáncer.
Se han encontrado 18 productos de "Alquilación de ADN"
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Chlorambucil
CAS:Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.Fórmula:C14H19Cl2NO2Pureza:97.37% - 98.45%Forma y color:Off-White Slightly Granular Powder Melting Point 65-69°CPeso molecular:304.21Phosphoramide mustard
CAS:Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.Fórmula:C4H11Cl2N2O2PPureza:93.00%Forma y color:SolidPeso molecular:221.02Methyl methanesulfonate
CAS:Methyl methanesulfonate alkylates adenine and guanine, causing base mismatches and replication issues.Fórmula:C2H6O3SPureza:99.69%Forma y color:SolidPeso molecular:110.13Melphalan
CAS:Melphalan is an orally bioavailable DNA alkylating agent exhibiting antitumour activity, commonly employed in cancer chemotherapy.Fórmula:C13H18Cl2N2O2Forma y color:SolidPeso molecular:305.21Methyl methanesulfonate (Standard)
CAS:Methyl methanesulfonate (Standard) is a standard material used in the analysis of methyl methanesulfonate, typically referenced in its research and analysis.Fórmula:C2H6O3SForma y color:LiquidPeso molecular:110.13Phosphoramide mustard cyclohexanamine
CAS:Phosphoramide mustard cyclohexanamine is active metabolite of cyclophosphamide, an alkylating agent that cross-links DNA strands,causes cell death, antitumor.Fórmula:C10H24Cl2N3O2PPureza:95%Forma y color:SolidPeso molecular:320.2Lomeguatrib
CAS:Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .Fórmula:C10H8BrN5OSPureza:99.26% - >99.99%Forma y color:SolidPeso molecular:326.17Carmustine
CAS:Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.Fórmula:C5H9Cl2N3O2Pureza:98% - 99.91%Forma y color:Light Yellow Powder Physical Description Orange-Yellow Solid (Ntp 1992)Peso molecular:214.05Palifosfamide
CAS:Palifosfamide lysine (ZIO-201) stable, effective vs. sarcomas in vitro. IC50: 2.25-6.75 μM, except OS222 at 31.5 μM.Fórmula:C4H11Cl2N2O2PPureza:99.72%Forma y color:SolidPeso molecular:221.02Tretazicar
CAS:CB1954, an anticancer prodrug, turns into a potent alkylating agent when activated by NQO2 and EP-0152R.Fórmula:C9H8N4O5Pureza:99.41% - 99.7%Forma y color:SolidPeso molecular:252.18GNE-3511
CAS:GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.Fórmula:C23H26F2N6OPureza:98.3% - 99.51%Forma y color:SolidPeso molecular:440.49VAL-083
CAS:VAL-083 (Dianhydrogalactitol) is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.Fórmula:C6H10O4Pureza:97.94%Forma y color:SolidPeso molecular:146.14Treosulfan
CAS:Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.Cost-effective and quality-assured.Fórmula:C6H14O8S2Pureza:99.26% - 99.75%Forma y color:SolidPeso molecular:278.3Ref: TM-T17159
5mg37,00€10mg55,00€25mg100,00€50mg173,00€100mg309,00€200mg432,00€1mL*10mM (DMSO)42,00€Miriplatin hydrate
CAS:Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).Fórmula:C34H70N2O5PtPureza:99.6%Forma y color:SolidPeso molecular:782.01DN-1289
DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) & LZK (IC50=40nM), blocks p-c-Jun in mouse optic nerve crush.
Fórmula:C18H19F4N7O2Pureza:98.56%Forma y color:SolidPeso molecular:441.38GNE-8505
CAS:GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).Fórmula:C21H24F3N5OForma y color:SolidPeso molecular:419.44IACS-52825
CAS:IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model and can be used to study neurological disorders.Fórmula:C16H13F7N4O2Pureza:99.77%Forma y color:SolidPeso molecular:426.29DLK-IN-1
CAS:DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.Fórmula:C20H24F3N5O2Forma y color:SolidPeso molecular:423.43
