Receptor de andrógenos
El receptor de andrógenos (AR) es un receptor hormonal nuclear que se activa al unirse a andrógenos, como la testosterona y la dihidrotestosterona. Este receptor juega un papel crucial en el desarrollo y mantenimiento de las características masculinas, así como en la regulación de varios procesos fisiológicos, incluyendo el crecimiento muscular, la libido y la densidad ósea. Los inhibidores del receptor de andrógenos son ampliamente estudiados en el contexto del cáncer de próstata, donde la señalización del AR a menudo está sobreexpresada. En CymitQuimica, ofrecemos una gama de moduladores del receptor de andrógenos de alta calidad para apoyar su investigación en endocrinología, biología del cáncer y regulación hormonal.
Se han encontrado 208 productos de "Receptor de andrógenos"
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VNPP433-3β
CAS:<p>VNPP433-3β acts as a molecular glue degrader, targeting the androgen receptor (AR) and its splice variants (AR-Vs) as well as MAP kinase-interacting serine/threonine protein kinase Mnk1/2. It effectively inhibits the proliferation of cancer cells LNCaP, C4-2B, and CWR22Rv1, with GI50 values of 0.2, 0.3, and 0.31 μM, respectively. Additionally, VNPP433-3β shows favorable pharmacokinetics in CD-1 mice and suppresses tumor growth in the CWR22Rv1 xenograft mouse model.</p>Fórmula:C29H34N4Forma y color:SolidPeso molecular:438.61AR/BET protein degrader-1
CAS:<p>AR/BET protein degrader-1 (Compound 149) is a dual-targeting protein degrader of Androgen Receptor and BET (bromodomain and extra-terminal domain), suitable for cancer research.</p>Fórmula:C43H44N6O5Peso molecular:724.85Androgen receptor antagonist 12
CAS:<p>Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.</p>Fórmula:C12H8F3N3O2Forma y color:SolidPeso molecular:283.21Androgen receptor ligand 1
CAS:<p>Androgen receptorligand 1 is a ligand for the androgen receptor (AR). It interacts with the CRBN E3 ligase via a linker to form an AR-PROTAC degrader. This compound is useful in prostate cancer research.</p>Fórmula:C19H16F4N2OForma y color:SolidPeso molecular:364.34Androgen receptor antagonist 11
CAS:<p>Androgen receptor antagonist 11 (compound N29) is a selective, orally available antagonist.</p>Fórmula:C20H19F3N4O3SForma y color:SolidPeso molecular:452.45A4B17
<p>A4B17 is an inhibitor of androgen receptor N-terminal with potential for androgen-responsive prostate cancer treatment.</p>Fórmula:C14H7F4NSForma y color:SolidPeso molecular:297.27PF-998425
CAS:<p>non-steroidal androgen receptor (AR) antagonist</p>Fórmula:C14H14F3NOPureza:98%Forma y color:SolidPeso molecular:269.26YK11
CAS:<p>YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM, with osteogenic activity.</p>Fórmula:C25H34O6Pureza:98.91%Forma y color:SoildPeso molecular:430.53
