NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Se han encontrado 445 productos de "NF-κB"
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DMX-129
CAS:<p>DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].</p>Fórmula:C19H17FN8Forma y color:SolidPeso molecular:376.39TNF-α-IN-18
CAS:<p>TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.</p>Fórmula:C16H7ClF2O4Pureza:99.77%Forma y color:SolidPeso molecular:336.67Anti-inflammatory agent 21
CAS:<p>Compound 9o: orally active, low-toxicity anti-inflammatory; inhibits NO (IC50: 0.76 μM), blocks NF-κB/MAPK, reduces arthritis symptoms.</p>Fórmula:C24H21FO6Forma y color:SolidPeso molecular:424.42HSR1304
CAS:<p>HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.</p>Fórmula:C24H21ClN2O3Forma y color:SolidPeso molecular:420.89Xanthine oxidase-IN-6
<p>Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.</p>Fórmula:C29H34N2O15Forma y color:SolidPeso molecular:650.58NF-κB/PON1-IN-1
CAS:<p>NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.</p>Fórmula:C20H16N6O4S2Forma y color:SolidPeso molecular:468.51RI-962
CAS:<p>RI-962 is a potent and selective inhibitor of RIPK1 that protects cells from necrotic apoptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation.</p>Fórmula:C28H28N6O2Pureza:99.39%Forma y color:SoildPeso molecular:480.56TRAF-STOP inhibitor 6877002
CAS:<p>TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.</p>Fórmula:C17H17NOPureza:99.76%Forma y color:SolidPeso molecular:251.32Bay 65-1942 free base
CAS:<p>Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.</p>Fórmula:C22H25N3O4Pureza:98%Forma y color:SolidPeso molecular:395.45Asperbisabolane L
<p>Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.</p>Fórmula:C12H14O3Forma y color:SolidPeso molecular:206.24TBK1/IKKε-IN-4
CAS:<p>TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM</p>Fórmula:C28H35N7O4Forma y color:SolidPeso molecular:533.62PHA-408
CAS:<p>PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.</p>Fórmula:C29H27ClFN7O2Pureza:98%Forma y color:SolidPeso molecular:560.02IMD-catechol
CAS:<p>IMD-catechol: an imidazoquinolinone-based dimer with NF-κB activity; improves CT26 cancer treatment, low toxicity.</p>Fórmula:C31H34N6O3Pureza:98%Forma y color:SolidPeso molecular:538.64NF-κB-IN-8
CAS:<p>NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.</p>Fórmula:C24H21N3O3Pureza:98%Forma y color:SolidPeso molecular:399.44CAY10575
CAS:<p>CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.</p>Fórmula:C22H21N3O6S2Forma y color:SolidPeso molecular:487.55IMD-biphenylA
CAS:<p>IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immune</p>Fórmula:C35H33N5O2Pureza:98%Forma y color:SolidPeso molecular:555.67NF-κB-IN-11
CAS:<p>NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.</p>Fórmula:C19H18O5Pureza:98%Forma y color:SolidPeso molecular:326.34HE 3286
CAS:<p>Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.</p>Fórmula:C21H30O3Forma y color:SolidPeso molecular:330.46SP-100030
CAS:<p>SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.</p>Fórmula:C14H5ClF9N3OPureza:99.79%Forma y color:SolidPeso molecular:437.65Zabedosertib
CAS:<p>Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.</p>Fórmula:C20H21F3N4O4SPureza:98.54%Forma y color:SolidPeso molecular:470.47
