NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Se han encontrado 445 productos de "NF-κB"
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IRAK4-IN-28
CAS:<p>IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme.</p>Fórmula:C27H31N9O3Pureza:98%Forma y color:SolidPeso molecular:529.59NF-κB-IN-13
CAS:<p>NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1</p>Fórmula:C20H20O5Pureza:98%Forma y color:SolidPeso molecular:340.37(Rac)-BAY-985
CAS:<p>(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.</p>Fórmula:C27H30F3N9OPureza:98%Forma y color:SolidPeso molecular:553.58ACHP Hydrochloride
CAS:<p>ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.</p>Fórmula:C21H25ClN4O2Pureza:99.83%Forma y color:SolidPeso molecular:400.9RIPK2-IN-3
CAS:<p>RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor with anti-inflammatory and anticancer activities, useful for research on immune diseases and cancer.</p>Fórmula:C25H22N4O2Pureza:99.57%Forma y color:SolidPeso molecular:410.47IR-Crizotinib
CAS:<p>IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial</p>Fórmula:C53H57Cl2FIN7OPureza:98%Forma y color:SolidPeso molecular:1024.88Trovafloxacin mesylate
CAS:<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Fórmula:C21H19F3N4O6SPureza:99.18%Forma y color:SolidPeso molecular:512.46IKK-IN-4
CAS:<p>IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].</p>Fórmula:C18H19N5SForma y color:SolidPeso molecular:337.44Bay 65-1942 (R form)
CAS:<p>Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.</p>Fórmula:C22H25N3O4Pureza:98%Forma y color:SolidPeso molecular:395.45GGTI 2147
CAS:<p>GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.</p>Fórmula:C28H30N4O3Pureza:98.69%Forma y color:SolidPeso molecular:470.56IKK-IN-1
CAS:<p>IKK-IN-1 is an inhibitor of IKK.</p>Fórmula:C22H26ClN3O4Pureza:98%Forma y color:SolidPeso molecular:431.91Glabrescone C
CAS:<p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>Fórmula:C19H22O7Forma y color:SolidPeso molecular:362.37Dimethoxycurcumin
CAS:<p>Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.</p>Fórmula:C23H24O6Pureza:99.87%Forma y color:SolidPeso molecular:396.43Supercinnamaldehyde
CAS:<p>Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ion</p>Fórmula:C12H11NO2Pureza:98.89%Forma y color:SolidPeso molecular:201.22Oditrasertib
CAS:<p>Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.</p>Fórmula:C14H15F2N3O2Pureza:98.65% - 99.65%Forma y color:SolidPeso molecular:295.28LTβR-IN-1
CAS:<p>LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor.</p>Fórmula:C18H16N4O2Pureza:98.93%Forma y color:SolidPeso molecular:320.35RIPK1-IN-4
CAS:<p>RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s</p>Fórmula:C23H23N5O2Pureza:99.94%Forma y color:SolidPeso molecular:401.46MAY0132
CAS:<p>MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.</p>Fórmula:C16H15ClF3NForma y color:SolidPeso molecular:313.745AS2690168 (free base)
CAS:<p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Fórmula:C17H13F3N4OForma y color:SolidPeso molecular:346.306SBI-0640726
CAS:<p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>Fórmula:C23H15ClN2O2Forma y color:SolidPeso molecular:386.83
