NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Se han encontrado 445 productos de "NF-κB"
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Coronalolic acid
CAS:<p>Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.</p>Fórmula:C30H46O4Pureza:98%Forma y color:SolidPeso molecular:470.68CIB-1476
<p>CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.</p>Fórmula:C28H28N2O6SForma y color:SolidPeso molecular:520.6Cyclo(L-Pro-L-Val)
CAS:<p>Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.</p>Fórmula:C10H16N2O2Pureza:98.18%Forma y color:SolidPeso molecular:196.25(R)-(-)-Ibuprofen
CAS:<p>(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.</p>Fórmula:C13H18O2Pureza:99.86%Forma y color:SolidPeso molecular:206.28EN450
CAS:<p>EN450 is a targeted cysteine degrader of NF-κB with antiproliferative activity and potential anticancer activity for the study of leukemia.</p>Fórmula:C11H13ClN2O3SPureza:99.72%Forma y color:SoildPeso molecular:288.75PROTAC IRAK4 degrader-12
CAS:<p>PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)</p>Fórmula:C46H50ClF2N11O6Forma y color:SolidPeso molecular:926.41RIPK1-IN-27
<p>RIPK1-IN-27 (compound 19) is an inhibitor of RIPK1.</p>Fórmula:C27H28N4O3Forma y color:SolidPeso molecular:456.54Gliotoxin
CAS:<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Fórmula:C13H14N2O4S2Pureza:98%Forma y color:SolidPeso molecular:326.39PROTAC STING degrader-3
<p>PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.</p>Forma y color:Odour SolidAnti-inflammatory agent 51
CAS:<p>Anti-inflammatory agent 51 amide/sulfonamide anti-inflammatory and anti-tumor activity inhibition of NF-κB activation acute lung injury and ulcerative colitis.</p>Fórmula:C22H22N6O6SPureza:99.46%Forma y color:SoildPeso molecular:498.51Antidesmone
CAS:<p>Antidesmone from Ajuga decumbens inhibits acute lung injury by modulating MAPK and NF-κB.</p>Fórmula:C19H29NO3Pureza:98%Forma y color:SolidPeso molecular:319.44SjDX5-271
CAS:<p>SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.</p>Fórmula:C137H215N47O49SForma y color:SolidPeso molecular:3336.52Aloenin aglycone
CAS:<p>Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate.</p>Fórmula:C13H12O5Pureza:98%Forma y color:SolidPeso molecular:248.23NBD peptide
CAS:<p>NBD peptide inhibits the NF-κB signaling pathway by preventing the binding of the NEMO-IKK complex. It exhibits anti-inflammatory activity by blocking the production of pro-inflammatory cytokines. Additionally, NBD peptide demonstrates immunosuppressive effects through the regulation of immune cells. It enhances transmembrane capacity by conjugating with the cell-penetrating peptide HIV-TAT.</p>Fórmula:C62H88N14O20Forma y color:SolidPeso molecular:1349.44SU1261
<p>SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.</p>Forma y color:Odour SolidPS 1145 dihydrochloride
CAS:<p>IκB kinase (IKK) inhibitor</p>Fórmula:C17H13Cl3N4OPureza:98%Forma y color:SolidPeso molecular:395.67Anti-osteoporosis agent-8
<p>Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.</p>Fórmula:C18H19F3N2O2SePeso molecular:432.05638LY2409881
CAS:<p>LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.</p>Fórmula:C24H29ClN6OSForma y color:SolidPeso molecular:485.05Salicortin
CAS:<p>Salicortin, a phenolic glycoside from Populus and Salix, has anti-adipogenic, anti-amnesic, and immune effects.</p>Fórmula:C20H24O10Pureza:98%Forma y color:SolidPeso molecular:424.40TBK1/IKKε-IN-6
CAS:<p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>Fórmula:C31H36F2N8O4Forma y color:SolidPeso molecular:622.678Siegesbeckialide I
<p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>Fórmula:C20H28O6Forma y color:SolidPeso molecular:364.43Diprovocim-1
CAS:<p>Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.</p>Fórmula:C56H56N6O6Forma y color:SolidPeso molecular:909.1SN50 TFA
<p>SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.</p>Fórmula:C129H230N36O29S·XCF3COOHForma y color:SolidPeso molecular:2781.5 (free base)Sootepin D
CAS:<p>Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.</p>Fórmula:C31H48O4Pureza:98%Forma y color:SolidPeso molecular:484.71Mesalamine impurity P
CAS:<p>Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.</p>Fórmula:C13H11NO6SForma y color:SolidPeso molecular:309.30Licoagrochalcone C
CAS:<p>Licoagrochalcone C, a flavonoid, inhibits NF-κB and NO production effectively.</p>Fórmula:C21H22O5Forma y color:SolidPeso molecular:354.47-O-Methylaloeasinol
CAS:<p>7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.</p>Fórmula:C20H26O9Forma y color:SolidPeso molecular:410.419Anti-inflammatory agent 7
<p>Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.</p>Fórmula:C36H40N4O9Forma y color:SolidPeso molecular:672.72Nasunin
CAS:<p>Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.</p>Fórmula:C42H47ClO23Forma y color:SolidPeso molecular:955.26COX-2-IN-48
<p>COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.</p>Forma y color:Odour SolidNLRP3-IN-51
<p>NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.</p>Forma y color:Odour SolidNF-κB-IN-9
<p>NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dual</p>Fórmula:C62H50N4O4SForma y color:SolidPeso molecular:947.15Murrayafoline A
CAS:<p>Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.</p>Fórmula:C14H13NOForma y color:SolidPeso molecular:211.264Ginger extract
CAS:<p>Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).</p>Forma y color:Solid12-Oxo phytodienoic acid
CAS:<p>12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.</p>Fórmula:C18H28O3Pureza:98%Forma y color:SolidPeso molecular:292.41MRT67307
CAS:<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Fórmula:C26H36N6O2Pureza:99.25% - 99.84%Forma y color:SolidPeso molecular:464.63-(2-Hydroxyethyl) thio withaferin A
<p>3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.</p>Fórmula:C30H44O7SForma y color:SolidPeso molecular:548.73RIPK1-IN-25
<p>RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.</p>Forma y color:Odour SolidPratensein
CAS:<p>Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.</p>Fórmula:C16H12O6Pureza:99.90%Forma y color:SolidPeso molecular:300.26Transcription Factor-Targeted Compound Library
<p>Well-chosen xnum compounds with unique structures targeting transcription factor;</p>Forma y color:Odour SolidMJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Forma y color:Odour SolidIKKγ NBD Inhibitory Peptide
CAS:<p>A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF</p>Fórmula:C170H259N49O42S1Pureza:98%Forma y color:SolidPeso molecular:3693.3R-HP210
<p>R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.</p>Fórmula:C22H19N3O2S2Forma y color:SolidPeso molecular:421.54CAY10512
CAS:<p>CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.</p>Fórmula:C15H13FOForma y color:SolidPeso molecular:228.266NF-κB Signaling Compound Library
<p>A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;</p>Forma y color:Odour Solid17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Fórmula:C22H32O3Forma y color:SolidPeso molecular:344.495CAY10657
CAS:<p>CAY10657 has a wide range of applications in life science related research.</p>Fórmula:C17H20N4O3SForma y color:SolidPeso molecular:360.43Lemnalol
CAS:<p>Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.</p>Fórmula:C15H24OPureza:98%Forma y color:SolidPeso molecular:220.35R1-ICR-5
CAS:<p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>Fórmula:C54H70N8O7S2Forma y color:SolidPeso molecular:1007.31N-Acetyldopamine dimer-2
CAS:<p>Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.</p>Fórmula:C20H20N2O6Forma y color:SolidPeso molecular:384.38
