CCR
Los receptores de quimiocinas C-C (CCRs) son un grupo de GPCR que responden a las quimiocinas, moléculas de señalización que guían la migración de células inmunitarias hacia sitios de inflamación o infección. Los CCR desempeñan un papel crucial en las respuestas inmunitarias, la inflamación y el desarrollo de diversas enfermedades, incluidas las enfermedades autoinmunes y el cáncer. La modulación de la actividad de los CCR se está explorando como una estrategia terapéutica para afecciones como la artritis reumatoide, la esclerosis múltiple y la infección por VIH. En CymitQuimica, ofrecemos una gama de moduladores de CCR de alta calidad para apoyar su investigación en inmunología, inflamación y desarrollo terapéutico.
Se han encontrado 136 productos de "CCR"
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RS 504393
CAS:<p>RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).</p>Fórmula:C25H27N3O3Pureza:98.64% - 99.62%Forma y color:SolidPeso molecular:417.5BMS-813160
CAS:<p>BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.</p>Fórmula:C25H40N8O2Pureza:99.66% - 99.79%Forma y color:SolidPeso molecular:484.64DAPTA
CAS:<p>DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.</p>Fórmula:C35H56N10O15Pureza:>99.99%Forma y color:SolidPeso molecular:856.88Vercirnon sodium
CAS:<p>Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.</p>Fórmula:C22H21ClN2NaO4SForma y color:SolidPeso molecular:467.92AZD2098
CAS:<p>AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.</p>Fórmula:C11H9Cl2N3O3SPureza:99.80% - >99.99%Forma y color:SolidPeso molecular:334.18Cenicriviroc
CAS:<p>Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.</p>Fórmula:C41H52N4O4SPureza:97.87%Forma y color:SolidPeso molecular:696.94INCB 3284
CAS:<p>INCB 3284, a potent human CCR2 antagonist with an IC50 of 3.7 nM, is researchable for acute liver failure and inhibits MCP-1/hCCR2 binding.</p>Fórmula:C26H31F3N4O4Pureza:97.81% - 99.42%Forma y color:SolidPeso molecular:520.54Carlumab
CAS:<p>Carlumab is a high-affinity human monoclonal antibody that targets CCL2, suppressing the recruitment of monocytes/macrophages in the tumour microenvironment.</p>Pureza:95%Forma y color:LiquidTivumecirnon
CAS:<p>Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumour</p>Fórmula:C24H27Cl2F3N6OPureza:99.88%Forma y color:SolidPeso molecular:543.41BI-6901
CAS:<p>BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.</p>Fórmula:C23H27N5O3SPureza:99.83%Forma y color:SolidPeso molecular:453.56CCR4 antagonist 3-1
CAS:<p>CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.</p>Fórmula:C14H12N2SPureza:99.53%Forma y color:SolidPeso molecular:240.32CCR1 antagonist 9
CAS:<p>CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. CCR1 inhibition in calcium flux assays.</p>Fórmula:C20H16FN5O3SPureza:99.13%Forma y color:SolidPeso molecular:425.44CCR8 antagonist 2
CAS:<p>CCR8 antagonist 2 blocks CCR8 activity, mainly on Treg and Th2 cells, for treating related diseases. See WO2022000443A1, compound 220.</p>Fórmula:C23H30ClN3O3SForma y color:SolidPeso molecular:464.02YM022
CAS:<p>YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.</p>Fórmula:C32H28N4O3Pureza:98%Forma y color:SolidPeso molecular:516.59CCR2 antagonist 3
CAS:<p>CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.</p>Fórmula:C17H25FN2O2Pureza:99.87%Forma y color:SolidPeso molecular:308.39GW 766994
CAS:<p>GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.</p>Fórmula:C21H24Cl2N4O3Pureza:98.77%Forma y color:SolidPeso molecular:451.35CCR1 antagonist 7
CAS:<p>CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].</p>Fórmula:C21H24ClN5O3SPureza:98%Forma y color:SolidPeso molecular:461.96RPT193
CAS:<p>RPT193 is an oral CCR4 inhibitor reducing Th2 cell migration in atopic dermatitis, asthma, and allergies.</p>Fórmula:C27H34Cl3N5O2Forma y color:SolidPeso molecular:566.95ALK4290
CAS:<p>ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.</p>Fórmula:C27H34ClN5O3Forma y color:SolidPeso molecular:512.04CCX354
CAS:<p>CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.</p>Fórmula:C22H22ClN7O2Pureza:99.82% - 99.82%Forma y color:SolidPeso molecular:451.91
