Nrf2
Nrf2 es un factor de transcripción que regula la expresión de proteínas antioxidantes y enzimas de desintoxicación, desempeñando un papel crucial en la defensa celular contra el estrés oxidativo y la inflamación. La activación de la señalización de Nrf2 proporciona protección contra diversas enfermedades, incluyendo el cáncer, la neurodegeneración y los trastornos cardiovasculares. Los moduladores de Nrf2 están siendo explorados por su potencial en aplicaciones terapéuticas para reducir el daño oxidativo y la inflamación. En CymitQuimica, ofrecemos una gama de moduladores de la vía Nrf2 de alta calidad para apoyar su investigación en estrés oxidativo, inflamación y prevención de enfermedades.
Se han encontrado 78 productos de "Nrf2"
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(+)-DHMEQ
CAS:<p>(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.</p>Fórmula:C13H11NO5Forma y color:SolidPeso molecular:261.23Dihydrolipoic acid
CAS:<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Fórmula:C8H16O2S2Pureza:97.51%Forma y color:Yellow To Orange LiquidPeso molecular:208.34Keap1-Nrf2-IN-12
CAS:<p>eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.</p>Fórmula:C26H28N2O10S2Forma y color:SolidPeso molecular:592.64Keap1-Nrf2-IN-13
CAS:<p>Keap1-Nrf2-IN-13 is a PPI inhibitor (IC50: 0.15 μM) that binds Keap1 strongly, useful for oxidative stress and inflammation research.</p>Fórmula:C28H32N2O10S2Forma y color:SolidPeso molecular:620.69Nrf2 activator-5
CAS:<p>Nrf2 activator-5 combats oxidative stress and inflammation in microglia, with potent antioxidant effects.</p>Fórmula:C25H30Cl2O6Forma y color:SolidPeso molecular:497.41Keap1-Nrf2-IN-14
CAS:<p>Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.</p>Fórmula:C30H29NO8SForma y color:SolidPeso molecular:563.62NXPZ-2
CAS:<p>NXPZ-2, an oral Keap1-Nrf2 PPI inhibitor (Ki: 95 nM, EC50: 120-170 nM), may improve cognition and neuron health in AD.</p>Fórmula:C27H27N5O7S2Forma y color:SolidPeso molecular:597.66SPC-180002
CAS:<p>SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.</p>Fórmula:C18H23NO4Pureza:98%Forma y color:SolidPeso molecular:317.38Stigmane B
<p>Stigmane B activates Nrf2, decreases apoptosis and ROS, boosts antioxidants, and is neuroprotective.</p>Fórmula:C21H30O4Forma y color:SolidPeso molecular:346.46BPK-29
CAS:<p>BPK-29 disrupts NR0B1 binding and modifies C274, inhibiting growth in KEAP1-mutant cancers.</p>Fórmula:C26H32ClN3O3Pureza:98%Forma y color:SolidPeso molecular:470AI-3
CAS:<p>Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor</p>Fórmula:C11H13ClO3S2Pureza:98%Forma y color:SolidPeso molecular:292.8Nrf2 activator-4
CAS:<p>Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.</p>Fórmula:C23H24ClF3N2O3Pureza:98.53%Forma y color:SolidPeso molecular:468.9K67
CAS:<p>K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.</p>Fórmula:C29H30N2O7S2Pureza:98.43%Forma y color:SolidPeso molecular:582.69DDO-7263
CAS:<p>DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.</p>Fórmula:C14H9F2N3OPureza:99.85%Forma y color:SolidPeso molecular:273.24CDDO-EA
CAS:<p>CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.</p>Fórmula:C33H46N2O3Pureza:99.66%Forma y color:SolidPeso molecular:518.73Keap1-Nrf2-IN-15
CAS:<p>Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence</p>Fórmula:C39H35N3O12S2Forma y color:SolidPeso molecular:801.84Keap1-Nrf2-IN-16
CAS:<p>Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.</p>Fórmula:C73H114N16O26Forma y color:SolidPeso molecular:1631.78Keap1-Nrf2-IN-6
<p>Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM</p>Fórmula:C30H34N4O8SForma y color:SolidPeso molecular:610.68Nrf2-IN-1
CAS:<p>Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).</p>Fórmula:C21H22ClN3O2Pureza:95.00% - 99.68%Forma y color:SolidPeso molecular:383.87Nrf2 activator-7
CAS:<p>Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.</p>Fórmula:C35H32N2O11S2Forma y color:SolidPeso molecular:720.77Nrf2-IN-3
CAS:<p>Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.</p>Fórmula:C22H26N4O4SPureza:98.07%Forma y color:SolidPeso molecular:442.53CPDT
CAS:<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Fórmula:C6H6S3Forma y color:SolidPeso molecular:174.307Nrf2 activator-2
<p>Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.</p>Fórmula:C20H17BrO3Forma y color:SolidPeso molecular:385.25Nrf2 activator-6
CAS:<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Fórmula:C31H37ClFN5O5Forma y color:SolidPeso molecular:614.11Keap1-Nrf2-IN-5
CAS:<p>Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).</p>Fórmula:C23H30N4O6SForma y color:SolidPeso molecular:490.57VVD-130037
CAS:<p>VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.</p>Fórmula:C17H17ClN4O2Pureza:99.01% - 99.92%Forma y color:SolidPeso molecular:344.8KI696
CAS:<p>KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.</p>Fórmula:C28H30N4O6SPureza:99.74%Forma y color:SolidPeso molecular:550.63NSC23925
CAS:<p>NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).</p>Fórmula:C22H26Cl2N2O2Pureza:98%Forma y color:SolidPeso molecular:421.36
