CXCR
Los CXCR son una subfamilia de GPCR que se unen a quimiocinas, pequeñas proteínas de señalización que guían el movimiento de las células inmunitarias hacia los sitios de inflamación, infección o lesión. Los CXCR desempeñan roles cruciales en las respuestas inmunitarias, la metástasis del cáncer y las enfermedades inflamatorias. Los moduladores de CXCR se están investigando por su potencial en el tratamiento de enfermedades autoinmunes, cáncer y afecciones inflamatorias crónicas. En CymitQuimica, ofrecemos una gama de moduladores de CXCR de alta calidad para apoyar su investigación en inmunología, oncología e inflamación.
Se han encontrado 167 productos para "CXCR".
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VUF-11222
CAS:VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Fórmula:C25H31BrINPureza:99.66%Forma y color:SolidPeso molecular:552.33RCP168
RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.Fórmula:C365H585N105O95S5Peso molecular:8119.27766CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Fórmula:C107H173N33O30Peso molecular:2400.30261CXCR7 modulator 1
CAS:CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.Fórmula:C48H57F2N7O7SPureza:98%Forma y color:SolidPeso molecular:914.07TC14012
CAS:CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).Fórmula:C90H140N34O19S2Pureza:98%Forma y color:SolidPeso molecular:2066.43CCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Fórmula:C13H22N6OSForma y color:SolidPeso molecular:310.15758ITIC
CAS:"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Fórmula:C94H82N4O2S4Pureza:98%Forma y color:SolidPeso molecular:1427.96Polyphemusin II-Derived Peptide
CAS:T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Fórmula:C90H141N33O18S2Forma y color:SolidPeso molecular:2037.42CTCE-9908
CAS:CXCR4 blocker; triggers cell division failure in ovarian cancer, boosts taxol and docetaxel treatment effects, proven in mice.Fórmula:C86H147N27O23Pureza:98%Forma y color:SolidPeso molecular:1927.27Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Fórmula:C39H59N13O8S2Forma y color:SolidPeso molecular:902.1VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Forma y color:Odour SolidPDE4D inhibitor 1
PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.Forma y color:Odour SolidPS372424 hydrochloride
CAS:PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.Fórmula:C33H45ClN6O4Pureza:95.03%Forma y color:Transparent ViscousPeso molecular:625.2ATI-2341
CAS:ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.Fórmula:C104H178N26O25S2Forma y color:SolidPeso molecular:2256.82Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Fórmula:C39H57N13O8S2·xC2HF3O2Forma y color:SolidPeso molecular:900.08 (free base)LY2510924
CAS:LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).Fórmula:C62H88N14O10Forma y color:SolidPeso molecular:1189.45Motixafortide
CAS:Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).Fórmula:C97H144FN33O19S2Pureza:98%Forma y color:SolidPeso molecular:2159.52CXCR2 antagonist 8
CAS:CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.Fórmula:C14H13N3O5Forma y color:Yellow SolidPeso molecular:303.27ACT-1004-1239
CAS:ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.Fórmula:C27H28F2N6O3Pureza:98.31%Forma y color:SolidPeso molecular:522.55AMD 3465 hexahydrobromide
CAS:AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.Fórmula:C24H44Br6N6Pureza:99.39%Forma y color:SolidPeso molecular:896.07
