CXCR
Los CXCR son una subfamilia de GPCR que se unen a quimiocinas, pequeñas proteínas de señalización que guían el movimiento de las células inmunitarias hacia los sitios de inflamación, infección o lesión. Los CXCR desempeñan roles cruciales en las respuestas inmunitarias, la metástasis del cáncer y las enfermedades inflamatorias. Los moduladores de CXCR se están investigando por su potencial en el tratamiento de enfermedades autoinmunes, cáncer y afecciones inflamatorias crónicas. En CymitQuimica, ofrecemos una gama de moduladores de CXCR de alta calidad para apoyar su investigación en inmunología, oncología e inflamación.
Se han encontrado 148 productos de "CXCR"
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FC131 TFA (606968-52-9 free base)
CAS:<p>FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv</p>Fórmula:C38H48F3N11O8Pureza:99.39% - 99.67%Forma y color:SolidPeso molecular:843.85ML 145
CAS:<p>ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM)</p>Fórmula:C24H22N2O5S2Pureza:97.74%Forma y color:SolidPeso molecular:482.57AMG 487 (S-enantiomer)
CAS:<p>AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.</p>Fórmula:C32H28F3N5O4Pureza:98%Forma y color:SolidPeso molecular:603.59AZ10397767
CAS:<p>AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.</p>Fórmula:C15H14ClFN4O2S2Forma y color:SolidPeso molecular:400.88rac-NBI-74330
CAS:<p>rac-NBI-74330 is an effective and selective CXCR3 antagonist.</p>Fórmula:C32H27F4N5O3Pureza:99.6%Forma y color:SolidPeso molecular:605.58VUF5834
CAS:<p>VUF5834 is a full inverse agonist of CXCR3 N3.35A.</p>Fórmula:C31H41N5O2Pureza:98%Forma y color:SolidPeso molecular:515.69SCH 546738
CAS:<p>SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.</p>Fórmula:C23H31Cl2N7OPureza:98.67%Forma y color:SolidPeso molecular:492.45KRH-1636
CAS:<p>KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.</p>Fórmula:C32H37N7O2Forma y color:SolidPeso molecular:551.68AMD 3465
CAS:<p>AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).</p>Fórmula:C24H38N6Pureza:98%Forma y color:SolidPeso molecular:410.60Burixafor hydrobromide
CAS:<p>Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.</p>Fórmula:C27H52BrN8O3PPureza:98%Forma y color:SolidPeso molecular:647.644VUF10132
CAS:<p>VUF10132 is a full inverse CXCR3 N3.35A agonist.</p>Fórmula:C19H13BrCl4N2O2Pureza:98%Forma y color:SolidPeso molecular:523.03IT1t
CAS:<p>IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.</p>Fórmula:C21H34N4S2Pureza:98%Forma y color:SolidPeso molecular:406.65ACT-660602
CAS:<p>ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.</p>Fórmula:C20H20F6N8OSForma y color:SolidPeso molecular:534.48CXCR3 Antagonist 6c
CAS:<p>CXCR3 antagonist 6c blocks CXCR3 and inhibits Ca2+ movement and T-cell migration (IC50: 0.06 µM & 100 nM) with selectivity over 14 other GPCRs.</p>Fórmula:C30H32Cl3N5O3Forma y color:SolidPeso molecular:616.97PS372424
CAS:<p>PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.</p>Fórmula:C33H44N6O4Pureza:98%Forma y color:SolidPeso molecular:588.74HF50731
CAS:<p>HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).</p>Fórmula:C26H46N4Forma y color:SolidPeso molecular:414.67SB02024
CAS:<p>SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.</p>Fórmula:C16H22F3N3O2Forma y color:SolidPeso molecular:345.36CXCR4 modulator-2
CAS:<p>CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.</p>Fórmula:C21H32N8O2Forma y color:SolidPeso molecular:428.53CXCR4 antagonist 5
CAS:<p>CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.</p>Fórmula:C21H30N6Forma y color:SolidPeso molecular:366.5ICT5040
CAS:<p>ICT5040 is a CXCR4 antagonist.</p>Fórmula:C10H8F3N3OSForma y color:SolidPeso molecular:275.25
