TGF-beta / Smad

Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside …

Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on …

Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a …

Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β …

Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin …

Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces …

GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.

PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the …

LSKL, Inhibitor of Thrombospondin (TSP-1) is a peptide derived from the latency-associated peptide, inhibits thrombospondin …

Disitertide acetate is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block …

SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.

RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor.

LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .

Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent …

ITD-1 is a potent and highly selective TGFβ pathway inhibitor.

Galunisertib is an orally available inhibitor of TGFβRI kinase (IC50: 56 nM) with potential antineoplastic …

LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of …

DMH-1 is a potent and selective BMP inhibitor.

Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, …

A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 …

K02288 is a novel small molecule inhibitor of ALK1/2/3/6.

Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced …

SB 4 is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)

BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).

Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit …

ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for …

HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the …

SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of …

BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.

Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans …

SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).

Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used …

TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. …

Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, …

Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor …

Astragaloside II is an effective MDR reversal agent and may be a potential adjunctive agent …

SB-431542 is a potent and selective inhibitor of ALK5 (IC50: 94 nM) and is also …

LDN-214117 is a potent and selective ALK2 inhibitor.

R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is …

LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I …

Dorsomorphin is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not …

SD-208, a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.

LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.

GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor …

LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).

Pentabromophenol suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.

SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).

Trimethylamine N-oxide dihydrate, a product of the oxidation of trimethylamine, is considered as a protein …

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.

BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: …

Hydroxysafflor yellow A inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively …

LDN193189 (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 …

Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in …

BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).

SIS3, a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has …

A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I …

SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.

SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of …

Alantolactone(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by …

SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits …

TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 …

TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, …