TGF-beta / Smad
Los inhibidores de TGF-beta/Smad son compuestos que interfieren con la vía de señalización TGF-beta (Transforming Growth Factor-beta), la cual es mediada por proteínas Smad. Esta vía está involucrada en la regulación del crecimiento celular, la diferenciación, la apoptosis y la función de las células madre. La desregulación de la señalización TGF-beta/Smad está asociada con el cáncer, la fibrosis y otras enfermedades. Los inhibidores de esta vía son herramientas importantes para estudiar estas condiciones y desarrollar posibles terapias. En CymitQuimica, ofrecemos inhibidores de TGF-beta/Smad para apoyar su investigación en señalización celular, oncología y reparación de tejidos.
Se han encontrado 58 productos de "TGF-beta / Smad"
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Halofuginone
CAS:<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Fórmula:C16H17BrClN3O3Pureza:99.53%Forma y color:Off-White SolidPeso molecular:414.68Chromenone 1
CAS:<p>Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).</p>Fórmula:C18H10F3N3O2Pureza:99.83% - 99.93%Forma y color:SolidPeso molecular:357.29Halofuginone hydrobromide
CAS:<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Fórmula:C16H17BrClN3O3·HBrPureza:97.01% - 99.73%Forma y color:SolidPeso molecular:495.59CJJ300
CAS:<p>CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.</p>Fórmula:C30H33N3Pureza:99.80%Forma y color:SolidPeso molecular:435.6(Rac)-SIS3 free base
CAS:SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Fórmula:C28H27N3O3Pureza:98%Forma y color:SolidPeso molecular:453.53TGFβRI-IN-1
CAS:<p>TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,</p>Fórmula:C20H14D3N5O2Pureza:98%Forma y color:SolidPeso molecular:362.4SJ000063181
CAS:<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Fórmula:C14H14ClFN2O2Pureza:99.94%Forma y color:SolidPeso molecular:296.723,7-DMF
CAS:3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Fórmula:C17H14O4Pureza:98%Forma y color:SolidPeso molecular:282.29DT-6
CAS:<p>DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing</p>Fórmula:C89H130N20O29S2Pureza:98%Forma y color:SolidPeso molecular:2008.23TGFβ-IN-5
CAS:<p>TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.</p>Fórmula:C20H16N4Pureza:99.29% - 99.5%Forma y color:SolidPeso molecular:312.37Myristoyl tetrapeptide-12
CAS:<p>Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].</p>Fórmula:C32H63N7O5Pureza:98%Forma y color:SolidPeso molecular:625.89TP0427736
CAS:TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.Fórmula:C14H10N4S2Pureza:97.26%Forma y color:SolidPeso molecular:298.39(+)-ITD-1
CAS:<p>(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).</p>Fórmula:C27H29NO3Forma y color:SolidPeso molecular:415.52CDD-1431
CAS:<p>CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.</p>Fórmula:C33H38N8O5SForma y color:SolidPeso molecular:658.77TGFβ1-IN-1
CAS:<p>TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.</p>Fórmula:C22H24N2O3Pureza:99.89% - 99.89%Forma y color:SolidPeso molecular:364.438TGFβRI-IN-3
CAS:<p>TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4.</p>Fórmula:C28H23N3O2SPureza:99.85%Forma y color:SoildPeso molecular:465.57Luspatercept
CAS:<p>Luspatercept (ACE-536), a recombinant modified ActRIIB fusion protein, selectively binds to transforming growth factor β superfamily ligands, thereby enhancing erythrocyte production and advancing the maturation of erythroid precursors. Moreover, by binding with GDF11, it inhibits Smad2/3 signaling. This compound is instrumental in anemia research [1].</p>Forma y color:LiquidDCN1-IN-2
CAS:<p>DCN1-IN-2, a DCN1 inhibitor, exhibits potent activity with an IC 50 of 2.96 nM. It effectively mitigates Ang II/TGFβ-induced activation of cardiac fibroblasts and diminishes ISO-induced cardiac fibrosis and remodeling in mice through the selective inhibition of cullin 3.</p>Fórmula:C18H14ClF3N4OSForma y color:SolidPeso molecular:426.84
