TGF-beta / Smad
Los inhibidores de TGF-beta/Smad son compuestos que interfieren con la vía de señalización TGF-beta (Transforming Growth Factor-beta), la cual es mediada por proteínas Smad. Esta vía está involucrada en la regulación del crecimiento celular, la diferenciación, la apoptosis y la función de las células madre. La desregulación de la señalización TGF-beta/Smad está asociada con el cáncer, la fibrosis y otras enfermedades. Los inhibidores de esta vía son herramientas importantes para estudiar estas condiciones y desarrollar posibles terapias. En CymitQuimica, ofrecemos inhibidores de TGF-beta/Smad para apoyar su investigación en señalización celular, oncología y reparación de tejidos.
Se han encontrado 58 productos de "TGF-beta / Smad"
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Garetosmab
CAS:<p>Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.</p>Pureza:> 95% - > 95%Forma y color:LiquidPeso molecular:146 kDaOxymatrine
CAS:<p>Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.</p>Fórmula:C15H24N2O2Pureza:98.72% - 99.72%Forma y color:SolidPeso molecular:264.36Ponsegromab
CAS:<p>Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.</p>Pureza:100% (SEC-HPLC) - > 95%Forma y color:LiquidPeso molecular:146.08 kDaHydrochlorothiazide
CAS:<p>Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。</p>Fórmula:C7H8ClN3O4S2Pureza:99.43% - 99.50%Forma y color:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Peso molecular:297.74Isoviolanthin
CAS:<p>Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal cells, potential HCC therapy.</p>Fórmula:C27H30O14Pureza:99.25% - 99.66%Forma y color:SolidPeso molecular:578.52Tubastatin
CAS:<p>Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.</p>Fórmula:C21H22N2O2Pureza:98.23%Forma y color:SolidPeso molecular:334.41Emugrobart
<p>Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Forma y color:Odour LiquidCBT-295
<p>CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and IL-6, along with the bile duct proliferation marker CK-19, and ameliorates liver fibrosis. The compound's ability to reverse liver fibrosis contributes to lowered ammonia levels in the blood and brain, which in turn reduces ammonia-induced neuroinflammation. CBT-295 shows potential for the study of liver cirrhosis and related encephalopathy.</p>Fórmula:C18H20ClN3OForma y color:SolidPeso molecular:329.82Linavonkibart
CAS:<p>Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.</p>Pureza:97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Forma y color:LiquidSotatercept
CAS:<p>Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.</p>Pureza:97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Forma y color:LiquidFresolimumab
CAS:<p>Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.</p>Pureza:> 95% - > 95%Forma y color:LiquidPeso molecular:144.4 kDaALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Fórmula:C20H23N7O2SForma y color:SolidPeso molecular:425.51TGFβRI-IN-7
<p>TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.</p>Fórmula:C27H32N6O2Forma y color:SolidPeso molecular:472.582Cirevetmab
CAS:<p>Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.</p>Forma y color:LiquidSLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:<p>SLLK is a control peptide for LSKL.</p>Fórmula:C21H41N5O6Pureza:98%Forma y color:SolidPeso molecular:459.58Rilogrotug
<p>Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Forma y color:Odour LiquidLerdelimumab
CAS:<p>Lerdelimumab (CAT-152) is an IgG4 monoclonal antibody targeting TGF-β2, used in glaucoma scarring research.</p>Forma y color:LiquidBintrafusp alfa
CAS:<p>Bintrafusp alfa (M7824) is a protein consisting of the extracellular structural domain of TGF-βRII with a monoclonal antibody to human immunoglobulin G1.</p>Pureza:96.1% (SDS-PAGE); 99.2% (SEC-HPLC) - 96.1% (SDS-PAGE); 99.2% (SEC-HPLC)Forma y color:LiquidSD-208
CAS:<p>SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.</p>Fórmula:C17H10ClFN6Pureza:98.72% - 99.65%Forma y color:SolidPeso molecular:352.75SRI-011381 hydrochloride
CAS:<p>SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Fórmula:C20H32ClN3OPureza:99.32% - 99.41%Forma y color:SolidPeso molecular:365.94Asiaticoside
CAS:<p>Asiaticoside, in Centella asiatica, may treat wounds/burns.</p>Fórmula:C48H78O19Pureza:98% - 99.96%Forma y color:PowderPeso molecular:959.12Chebulinic acid
CAS:<p>Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.</p>Fórmula:C41H32O27Pureza:98.91% - 99.71%Forma y color:SolidPeso molecular:956.68(E)-SIS3
CAS:<p>(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!</p>Fórmula:C28H27N3O3·HClPureza:95.64% - 98%Forma y color:SolidPeso molecular:489.99R-268712
CAS:<p>R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.</p>Fórmula:C20H18FN5OPureza:99.61%Forma y color:SolidPeso molecular:363.39SJ000291942
CAS:<p>SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.</p>Fórmula:C16H15FN2O4Pureza:99.66%Forma y color:SolidPeso molecular:318.3LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Fórmula:C25H44F6N6O9Pureza:99.75%Forma y color:SolidPeso molecular:686.64Kartogenin
CAS:<p>Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.</p>Fórmula:C20H15NO3Pureza:96.25% - 97.79%Forma y color:SolidPeso molecular:317.34ITD-1
CAS:<p>ITD-1 is a potent and highly selective TGFβ pathway inhibitor.</p>Fórmula:C27H29NO3Pureza:99.89% - >99.99%Forma y color:SolidPeso molecular:415.52Galunisertib
CAS:<p>Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C22H19N5OPureza:97.09% - 99.98%Forma y color:SolidPeso molecular:369.42Alantolactone
CAS:<p>Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.</p>Fórmula:C15H20O2Pureza:99.02% - 99.66%Forma y color:Crystalline PowderPeso molecular:232.32BMP signaling agonist sb4
CAS:<p>BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)</p>Fórmula:C14H10BrNOSPureza:99.48% - 99.805%Forma y color:SolidPeso molecular:320.2BMS986260
CAS:<p>BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).</p>Fórmula:C18H12ClFN6OPureza:97.67%Forma y color:SolidPeso molecular:382.78BIO-013077-01
CAS:<p>BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.</p>Fórmula:C17H13N5Pureza:99.87%Forma y color:SolidPeso molecular:287.32Trimethylamine N-oxide dihydrate
CAS:<p>TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.</p>Fórmula:C3H13NO3Pureza:98.75%Forma y color:White CrystalPeso molecular:111.14LY3200882
CAS:<p>LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).</p>Fórmula:C24H29N5O3Pureza:99.46% - 99.63%Forma y color:SolidPeso molecular:435.52SRI-011381
CAS:<p>SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Fórmula:C20H31N3OPureza:98.64%Forma y color:SolidPeso molecular:329.48Trevogrumab
CAS:<p>Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).</p>Pureza:95% - 95%Forma y color:LiquidNisevokitug
CAS:<p>Nisevokitug (anti-TGF-β mAb) neutralizes TGF-β and is being studied for its ability to modulate the immunosuppressive tumor microenvironment.</p>Pureza:95%Forma y color:LiquidMetelimumab
CAS:<p>Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).</p>Pureza:95%Forma y color:LiquidLivmoniplimab
CAS:<p>Livmoniplimab (ABBV-151; ARGX-115) is a humanised monoclonal antibody targeting LRRC32 (GARP)/TGFβ1, which blocks TGFβ1 release mediated by LRRC32</p>Pureza:95%Forma y color:LiquidHalofuginone
CAS:<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Fórmula:C16H17BrClN3O3Pureza:99.53%Forma y color:Off-White SolidPeso molecular:414.68Chromenone 1
CAS:<p>Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).</p>Fórmula:C18H10F3N3O2Pureza:99.83% - 99.93%Forma y color:SolidPeso molecular:357.29Halofuginone hydrobromide
CAS:<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Fórmula:C16H17BrClN3O3·HBrPureza:97.01% - 99.73%Forma y color:SolidPeso molecular:495.59CJJ300
CAS:<p>CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.</p>Fórmula:C30H33N3Pureza:99.80%Forma y color:SolidPeso molecular:435.6(Rac)-SIS3 free base
CAS:SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Fórmula:C28H27N3O3Pureza:98%Forma y color:SolidPeso molecular:453.53TGFβRI-IN-1
CAS:<p>TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,</p>Fórmula:C20H14D3N5O2Pureza:98%Forma y color:SolidPeso molecular:362.4SJ000063181
CAS:<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Fórmula:C14H14ClFN2O2Pureza:99.94%Forma y color:SolidPeso molecular:296.723,7-DMF
CAS:3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Fórmula:C17H14O4Pureza:98%Forma y color:SolidPeso molecular:282.29DT-6
CAS:<p>DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing</p>Fórmula:C89H130N20O29S2Pureza:98%Forma y color:SolidPeso molecular:2008.23TGFβ-IN-5
CAS:<p>TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.</p>Fórmula:C20H16N4Pureza:99.29% - 99.5%Forma y color:SolidPeso molecular:312.37Myristoyl tetrapeptide-12
CAS:<p>Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].</p>Fórmula:C32H63N7O5Pureza:98%Forma y color:SolidPeso molecular:625.89TP0427736
CAS:TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.Fórmula:C14H10N4S2Pureza:97.26%Forma y color:SolidPeso molecular:298.39(+)-ITD-1
CAS:<p>(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).</p>Fórmula:C27H29NO3Forma y color:SolidPeso molecular:415.52CDD-1431
CAS:<p>CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.</p>Fórmula:C33H38N8O5SForma y color:SolidPeso molecular:658.77TGFβ1-IN-1
CAS:<p>TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.</p>Fórmula:C22H24N2O3Pureza:99.89% - 99.89%Forma y color:SolidPeso molecular:364.438TGFβRI-IN-3
CAS:<p>TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4.</p>Fórmula:C28H23N3O2SPureza:99.85%Forma y color:SoildPeso molecular:465.57Luspatercept
CAS:<p>Luspatercept (ACE-536), a recombinant modified ActRIIB fusion protein, selectively binds to transforming growth factor β superfamily ligands, thereby enhancing erythrocyte production and advancing the maturation of erythroid precursors. Moreover, by binding with GDF11, it inhibits Smad2/3 signaling. This compound is instrumental in anemia research [1].</p>Forma y color:LiquidDCN1-IN-2
CAS:<p>DCN1-IN-2, a DCN1 inhibitor, exhibits potent activity with an IC 50 of 2.96 nM. It effectively mitigates Ang II/TGFβ-induced activation of cardiac fibroblasts and diminishes ISO-induced cardiac fibrosis and remodeling in mice through the selective inhibition of cullin 3.</p>Fórmula:C18H14ClF3N4OSForma y color:SolidPeso molecular:426.84
