TGF-beta / Smad
Los inhibidores de TGF-beta/Smad son compuestos que interfieren con la vía de señalización TGF-beta (Transforming Growth Factor-beta), la cual es mediada por proteínas Smad. Esta vía está involucrada en la regulación del crecimiento celular, la diferenciación, la apoptosis y la función de las células madre. La desregulación de la señalización TGF-beta/Smad está asociada con el cáncer, la fibrosis y otras enfermedades. Los inhibidores de esta vía son herramientas importantes para estudiar estas condiciones y desarrollar posibles terapias. En CymitQuimica, ofrecemos inhibidores de TGF-beta/Smad para apoyar su investigación en señalización celular, oncología y reparación de tejidos.
Se han encontrado 61 productos de "TGF-beta / Smad"
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SRI-011381 hydrochloride
CAS:SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H32ClN3OPureza:99.32% - 99.41%Forma y color:SolidPeso molecular:365.94Ref: TM-T5129
1mg35,00€2mg47,00€5mg70,00€10mg111,00€25mg227,00€50mg354,00€100mg525,00€200mg797,00€1mL*10mM (DMSO)77,00€Asiaticoside
CAS:Asiaticoside, in Centella asiatica, may treat wounds/burns.Fórmula:C48H78O19Pureza:98% - 99.96%Forma y color:PowderPeso molecular:959.12Chebulinic acid
CAS:Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.Fórmula:C41H32O27Pureza:98.91% - 99.71%Forma y color:SolidPeso molecular:956.68Ref: TM-TQ0184
1mg70,00€5mg154,00€10mg215,00€25mg432,00€50mg628,00€100mg879,00€1mL*10mM (DMSO)226,00€(E)-SIS3
CAS:(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!Fórmula:C28H27N3O3·HClPureza:95.64% - 98%Forma y color:SolidPeso molecular:489.99Ref: TM-T3636
1mg43,00€2mg57,00€5mg111,00€10mg167,00€25mg344,00€50mg512,00€100mg730,00€500mg1.473,00€1mL*10mM (DMSO)120,00€R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Fórmula:C20H18FN5OPureza:99.61%Forma y color:SolidPeso molecular:363.39Ref: TM-T16708
1mg44,00€5mg93,00€10mg130,00€25mg250,00€50mg378,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)92,00€SJ000291942
CAS:SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Fórmula:C16H15FN2O4Pureza:99.66%Forma y color:SolidPeso molecular:318.3Ref: TM-T4662
1mg35,00€2mg47,00€5mg66,00€10mg105,00€25mg216,00€50mg369,00€100mg588,00€200mg833,00€1mL*10mM (DMSO)74,00€LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Fórmula:C25H44F6N6O9Pureza:99.75%Forma y color:SolidPeso molecular:686.64Ref: TM-T7676
2mg44,00€5mg57,00€10mg88,00€25mg145,00€50mg217,00€100mg334,00€200mg467,00€1mL*10mM (DMSO)87,00€Kartogenin
CAS:Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Fórmula:C20H15NO3Pureza:96.25% - 97.79%Forma y color:SolidPeso molecular:317.34ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Fórmula:C27H29NO3Pureza:99.89% - >99.99%Forma y color:SolidPeso molecular:415.52Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C22H19N5OPureza:97.09% - 99.98%Forma y color:SolidPeso molecular:369.42Ref: TM-T2510
1g657,00€5mg46,00€10mg52,00€25mg84,00€50mg114,00€100mg178,00€200mg269,00€500mg442,00€1mL*10mM (DMSO)52,00€Alantolactone
CAS:Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.Fórmula:C15H20O2Pureza:99.02% - 99.66%Forma y color:Crystalline PowderPeso molecular:232.32BMP signaling agonist sb4
CAS:BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Fórmula:C14H10BrNOSPureza:99.48% - 99.805%Forma y color:SolidPeso molecular:320.2Ref: TM-T7799
5mg44,00€10mg57,00€25mg94,00€50mg119,00€100mg177,00€200mg268,00€500mg465,00€1mL*10mM (DMSO)48,00€BMS986260
CAS:BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).Fórmula:C18H12ClFN6OPureza:97.67%Forma y color:SolidPeso molecular:382.78BIO-013077-01
CAS:BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Fórmula:C17H13N5Pureza:99.87%Forma y color:SolidPeso molecular:287.32Ref: TM-T8330
1mg50,00€5mg92,00€10mg140,00€25mg273,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)138,00€Trimethylamine N-oxide dihydrate
CAS:TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.Fórmula:C3H13NO3Pureza:98.75%Forma y color:White CrystalPeso molecular:111.14LY3200882
CAS:LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Fórmula:C24H29N5O3Pureza:99.46% - 99.63%Forma y color:SolidPeso molecular:435.52SRI-011381
CAS:SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H31N3OPureza:98.64%Forma y color:SolidPeso molecular:329.48Nisevokitug
CAS:Nisevokitug (anti-TGF-β mAb) neutralizes TGF-β and is being studied for its ability to modulate the immunosuppressive tumor microenvironment.Pureza:95%Forma y color:LiquidPeso molecular:143.51 kDaGinisortamab
CAS:Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, IC50=8.2 nM and 9 nM against human and mouse Gremlin-1, respectively.Pureza:95% - 96.0% (SDS-PAGE); 97.0% (SEC-HPLC)Forma y color:LiquidPeso molecular:147.55 kDaMetelimumab
CAS:Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).Pureza:95%Forma y color:Liquid
