TGF-beta / Smad
Los inhibidores de TGF-beta/Smad son compuestos que interfieren con la vía de señalización TGF-beta (Transforming Growth Factor-beta), la cual es mediada por proteínas Smad. Esta vía está involucrada en la regulación del crecimiento celular, la diferenciación, la apoptosis y la función de las células madre. La desregulación de la señalización TGF-beta/Smad está asociada con el cáncer, la fibrosis y otras enfermedades. Los inhibidores de esta vía son herramientas importantes para estudiar estas condiciones y desarrollar posibles terapias. En CymitQuimica, ofrecemos inhibidores de TGF-beta/Smad para apoyar su investigación en señalización celular, oncología y reparación de tejidos.
Se han encontrado 83 productos para "TGF-beta / Smad".
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Garetosmab
CAS:Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.Pureza:95% - >95% (SDS-PAGE); 99.25% (SEC-HPLC)Forma y color:Transparent LiquidPeso molecular:145.52 kDa (Predicted)Isoviolanthin
CAS:Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal cells, potential HCC therapy.Fórmula:C27H30O14Pureza:99.25% - 99.66%Forma y color:SolidPeso molecular:578.5187Hydrochlorothiazide
CAS:Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。Fórmula:C7H8ClN3O4S2Pureza:99.43% - 99.50%Forma y color:White SolidPeso molecular:297.739Oxymatrine
CAS:Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.Fórmula:C15H24N2O2Pureza:98.72% - 99.72%Forma y color:White SolidPeso molecular:264.36SLLK
CAS:SLLK is a control peptide for LSKL.Fórmula:C21H41N5O6Pureza:98%Forma y color:SolidPeso molecular:459.58ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Fórmula:C20H23N7O2SForma y color:SolidPeso molecular:425.51LSKL TFA
CAS:LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a TGF-尾1 antagonist that inhibits TSP-1 binding to LAP and reduces renal interstitial fibrosis and liver fibrosis.Fórmula:C23H43F3N6O7Pureza:99.33%Forma y color:SolidPeso molecular:572.6187Sotatercept
CAS:Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.Pureza:96.2% (SDS-PAGE); 98.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Forma y color:Transparent LiquidPeso molecular:38.94 kDa (Predicted)P17 Peptide
CAS:P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.Fórmula:C95H139N27O21Forma y color:SolidPeso molecular:1995.29Tubastatin
CAS:Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Fórmula:C21H22N2O2Pureza:98.43%Forma y color:SolidPeso molecular:334.4116Linavonkibart
CAS:Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.Pureza:97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.68 kDa (Predicted)Domagrozumab
CAS:Domagrozumab (PF-06252616) is a humanized monoclonal antibody targeting myostatin, used in studies of muscle wasting diseases.Pureza:95.83% (SEC-HPLC) - >95.0% (SDS-PAGE); 98% (SEC-HPLC)Forma y color:LiquidPeso molecular:143.96 kDa (Predicted)Depiperazine-DM3189
CAS:Depiperazine-DM3189 inhibits the phosphorylation of SMAD 1/5/8 induced by bone morphogenetic protein 4 and can be used in biochemical experiments .Fórmula:C21H14N4Pureza:99.69%Peso molecular:322.36Myostatin inhibitory peptide 2 TFA
Myostatin Inhibitory Peptide 2 (compd 2) TFA is a potent inhibitor of muscle growth suppressant with a dissociation constant (Kd) of 35.9 nM. It is utilized in the study of muscle atrophy diseases.Forma y color:Odour SolidFresolimumab
CAS:Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.Pureza:> 95% - > 95%Forma y color:Transparent LiquidPeso molecular:144.4 kDa (Predicted)TGF-β1/Smad3-IN-1
CAS:TGF-β1/Smad3-IN-1 is an orally administrable dual inhibitor of TGF-β1/Smad3 with anti-fibrotic activity, idiopathic pulmonary fibrosis (IPF).Fórmula:C30H34N4O6SPureza:99.83%Peso molecular:578.68Elritercept
CAS:Elritercept (KER-050) is a recombinant fusion protein composed of a modified extracellular domain of the activin receptor type IIA fused to human IgG1 Fc. It functions by inhibiting activin A and other specific ligands of the TGF-β superfamily.Landogrozumab
CAS:Landogrozumab (LY2495655) is a humanized anti-GDF-8 monoclonal antibody that improves muscle size and may be used to study cancer and neurological disorders.Pureza:99% (SDS-PAGE); 97.5% (SEC-HPLC) - 99% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:Transparent LiquidPeso molecular:142.86 kDa (Predicted)Luspatercept
CAS:Luspatercept (ACE-536), a recombinant modified ActRIIB fusion protein, selectively binds to transforming growth factor β superfamily ligands, thereby enhancing erythrocyte production and advancing the maturation of erythroid precursors. Moreover, by binding with GDF11, it inhibits Smad2/3 signaling. This compound is instrumental in anemia research [1].Forma y color:LiquidDisitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Fórmula:C70H113N17O24S2Pureza:95.77%Forma y color:White SolidPeso molecular:1640.88
