MALT
El tejido linfoide asociado a mucosas (MALT) es un componente esencial del sistema inmunológico que protege las superficies mucosas de los patógenos. El MALT incluye estructuras como las amígdalas, las placas de Peyer y el apéndice, que están involucradas en la iniciación de respuestas inmunitarias a los antígenos que se encuentran en las superficies mucosas. La investigación sobre el MALT es fundamental para comprender los mecanismos de la inmunidad mucosal y para el desarrollo de vacunas y tratamientos para infecciones mucosales. En CymitQuimica, ofrecemos una gama de reactivos y herramientas para apoyar su investigación en inmunología mucosal, inflamación y enfermedades infecciosas.
Se han encontrado 26 productos para "MALT".
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MLT-231
MLT-231: potent MALT1 Inhibitor, IC50=9 nM; blocks BCL10 cleavage, IC50=160 nM; exhibits antitumor efficacy in mouse ABC-DLBCL model.Forma y color:SolidPROTAC MALT1 Degrader-1
CAS:PROTAC MALT1 Degrader-1 (Compound 176) is a MALT1 PROTAC degrader, utilized in lymphoma research.Fórmula:C42H47ClN12O5Peso molecular:835.35MALT1-IN-14
CAS:MALT1-IN-14 (comp 2) is a potent and selective MALT1 inhibitor with an IC50 value of 0.081 μM, widely utilized in immunology and oncology research to suppress MALT1 protease activity, dissect NF-κB signaling cascades, and evaluate therapeutic approaches targeting lymphoid malignancies and inflammatory diseases driven by dysregulated immune activation.Fórmula:C26H25ClF5N5O3SForma y color:SolidPeso molecular:618.02MLT-985
CAS:MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC50 of 3 nM, and can be used to study MALT1 signaling, cancer, and B-cell malignancies.Fórmula:C17H15Cl2N9O2Pureza:98.15%Forma y color:SolidPeso molecular:448.27Cladribine
CAS:Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.Fórmula:C10H12ClN5O3Pureza:99.58% - >99.99%Forma y color:SolidPeso molecular:285.687MALT1 inhibitor MI-2
CAS:MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.Fórmula:C19H17Cl3N4O3Pureza:98% - 99.87%Forma y color:SolidPeso molecular:455.72MLT-943
CAS:MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].Fórmula:C16H14ClF3N6O2Pureza:99.72% - 99.82%Forma y color:White SolidPeso molecular:414.77MLT-748
CAS:MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM).Fórmula:C19H19Cl2N9O3Pureza:99.20%Forma y color:SolidPeso molecular:492.319Z-VRPR-FMK
CAS:Z-VRPR-FMK: irreversible MALT1 inhibitor, halts growth/invasion of diffused B-cell lymphoma by blocking NF-κB activation and MMP expression.Fórmula:C31H49FN10O6Forma y color:SolidPeso molecular:676.78(R)-MALT1-IN-3
CAS:(R)-MALT1-IN-3 (121) inhibits MALT1 protease (IC50: 20 nM) and IL6/IL10 in OCI-LY3 (IC50: 60/40 nM).Fórmula:C21H19F3N8O2Forma y color:SolidPeso molecular:472.42(R)-MLT-985
CAS:(R)-MLT-985 (compound 11) is a MALT1 protease inhibitor with IC50 of 3 nM, also blocking IL-2 in Jurkat cells and ABC-DLBCL cell growth.Fórmula:C17H15Cl2N9O2Forma y color:SolidPeso molecular:448.27MALT1-IN-3
CAS:MALT1-IN-3 is a potent inhibitor of MALT1 protease (IC50: 0.06 μM) with IC50 values of 0.14 and 0.13 μM for human IL6 and IL10, respectively, in OCI-LY3 cells.Fórmula:C21H19F3N8O2Forma y color:SolidPeso molecular:472.42MALT1-IN-8
CAS:MALT1-IN-8: potent MALT1 inhibitor, IC50=2 nM; hinders OCI-LY3 cells, IC50=1.16 μM; anticancer, from patent WO2018165385A1.Fórmula:C20H15Cl2N7OForma y color:SolidPeso molecular:440.29MLT-747
CAS:MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM).Fórmula:C20H21Cl2N7O3Forma y color:SolidPeso molecular:478.332(R)-MALT1-IN-7
CAS:(R)-MALT1-IN-7 (compound 142a) is a potent inhibitor of MALT1 protease and has potential for cancer research.Fórmula:C19H17F3N8O2SForma y color:SolidPeso molecular:478.45NVS-MALT1
CAS:NVS-MALT1 is an allosteric inhibitor of MALT1 [1].Fórmula:C24H27ClF3N5O4SForma y color:SolidPeso molecular:574.02MALT1-IN-6
CAS:MALT1-IN-6 is a MALT1 protease inhibitor (Ki: 9 nM) that exhibits anticancer activity.Fórmula:C18H12Cl2F3N9OForma y color:SolidPeso molecular:498.25JNJ-67856633
CAS:JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease .Fórmula:C20H11F6N5O2Pureza:99.87%Forma y color:SolidPeso molecular:467.3241MALT1-IN-9
CAS:MALT1-IN-9: potent MALT1 protease inhibitor, IC50 <500 nM in Raji cells, significant anticancer effects.Fórmula:C16H12ClF3N6OForma y color:SolidPeso molecular:396.75MALT1-IN-7
CAS:MALT1-IN-7 (compound 142b) is a potent inhibitor of MALT1 protease with potential for cancer research.Fórmula:C19H17F3N8O2SForma y color:SolidPeso molecular:478.45
