JNK
Las JNK (c-Jun N-terminal kinases) son un subgrupo de la familia MAPK que responden a estímulos de estrés, como citoquinas, radiación ultravioleta y choque térmico, y están involucradas en el control de la apoptosis, la inflamación y las respuestas inmunitarias. La señalización de JNK es crucial para la regulación de las respuestas celulares al estrés y se ha implicado en diversas enfermedades, incluidas las neurodegenerativas, el cáncer y las afecciones inflamatorias. En CymitQuimica, ofrecemos una gama de moduladores de la vía JNK para apoyar su investigación en señalización de estrés, apoptosis y patología de enfermedades.
Se han encontrado 97 productos de "JNK"
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IQ-1S
CAS:<p>IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.</p>Fórmula:C15H8N3NaOForma y color:SolidPeso molecular:269.23L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Fórmula:C164H286N66O40Pureza:98%Forma y color:SolidPeso molecular:3822.44JNK-IN-18
<p>JNK-IN-18 (compound 23b) is a potent inhibitor of JNK1, boasting an IC50 of 2 nM. It demonstrates superior efficacy when compared to its IC50 values of 125 nM for JNK2 and 98 nM for BRAF(V600E).</p>Forma y color:Odour SolidJNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Fórmula:C32H30FN7O3Forma y color:SolidPeso molecular:579.62Vacquinol-1
CAS:<p>Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.</p>Fórmula:C21H21ClN2OPureza:98.67%Forma y color:SolidPeso molecular:352.86JNK2-IN-1
<p>JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α and</p>Fórmula:C30H26N4O5Pureza:98%Forma y color:SolidPeso molecular:522.55JNK-1-IN-3
CAS:<p>JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.</p>Fórmula:C19H17FN4O3Pureza:97.551%Forma y color:SolidPeso molecular:368.36Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Forma y color:Odour SolidD-JBD19
CAS:<p>D-JBD19 is a non-permeable peptide with neuroprotective effects.</p>Fórmula:C99H164N32O28Pureza:98%Forma y color:SolidPeso molecular:2250.597MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Forma y color:Odour SolidPROTAC JNK1-targeted-1
<p>PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]</p>Fórmula:C35H32BrN9O6Forma y color:SolidPeso molecular:754.589JNK-IN-14
<p>JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.</p>Fórmula:C27H31N5O4SPureza:98%Forma y color:SolidPeso molecular:521.63CC-401
CAS:<p>CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).</p>Fórmula:C22H24N6OPureza:98%Forma y color:SolidPeso molecular:388.47JIP-1(153-163)
CAS:<p>Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.</p>Fórmula:C61H104N20O14Pureza:98%Forma y color:SolidPeso molecular:1341.6JNK1 Protein, Human, Recombinant (GST)
<p>Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.</p>Forma y color:Lyophilized PowderPeso molecular:75 kDa (predicted); 65 kDa (reducing conditions)Ezatiostat
CAS:<p>Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.</p>Fórmula:C27H35N3O6SPureza:97.95%Forma y color:SolidPeso molecular:529.65Loureirin B
CAS:<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Fórmula:C18H20O5Pureza:99.33% - 99.86%Forma y color:SolidPeso molecular:316.35Taurochenodeoxycholic Acid
CAS:<p>Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.</p>Fórmula:C26H45NO6SPureza:99.53% - 99.86%Forma y color:SolidPeso molecular:499.7Ro 31-8220 Mesylate
CAS:<p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>Fórmula:C25H23N5O2S·CH4O3SPureza:98.79% - 99.02%Forma y color:SolidPeso molecular:553.65Astragaloside IV
CAS:<p>Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.</p>Fórmula:C41H68O14Pureza:99% - 99.84%Forma y color:Hydroscopic Brown Or Yellow PowderPeso molecular:784.97
