JNK
Las JNK (c-Jun N-terminal kinases) son un subgrupo de la familia MAPK que responden a estímulos de estrés, como citoquinas, radiación ultravioleta y choque térmico, y están involucradas en el control de la apoptosis, la inflamación y las respuestas inmunitarias. La señalización de JNK es crucial para la regulación de las respuestas celulares al estrés y se ha implicado en diversas enfermedades, incluidas las neurodegenerativas, el cáncer y las afecciones inflamatorias. En CymitQuimica, ofrecemos una gama de moduladores de la vía JNK para apoyar su investigación en señalización de estrés, apoptosis y patología de enfermedades.
Se han encontrado 105 productos para "JNK".
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Juglanin
CAS:Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.Fórmula:C20H18O10Pureza:98.8% - 99.33%Forma y color:SolidPeso molecular:418.35IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFórmula:C22H23N5O8Pureza:97.73%Forma y color:SolidPeso molecular:485.45Ref: TM-T9010
1mg38,00€5mg92,00€1mL*10mM (DMSO)124,00€10mg128,00€25mg215,00€50mg304,00€100mg411,00€200mg570,00€AS601245
CAS:AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.Fórmula:C20H16N6SPureza:98% - 99.02%Forma y color:SolidPeso molecular:372.45JNK Inhibitor VIII
CAS:JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,Fórmula:C18H20N4O4Pureza:98.93%Forma y color:SolidPeso molecular:356.38Taurochenodeoxycholic Acid
CAS:Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.Fórmula:C26H45NO6SPureza:99.48% - 99.86%Forma y color:SolidPeso molecular:499.7DB07268
CAS:DB07268 is a potent and selective JNK1 inhibitor.Fórmula:C17H15N5O2Pureza:98.2% - 98.91%Forma y color:Yellow SolidPeso molecular:321.33SP600125
CAS:SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitiveFórmula:C14H8N2OPureza:97.63% - 99.82%Forma y color:Yellow SolidPeso molecular:220.23BI-78D3
CAS:BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.Fórmula:C13H9N5O5S2Pureza:98.24% - 99.90%Forma y color:SolidPeso molecular:379.37Anisomycin
CAS:Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.Fórmula:C14H19NO4Pureza:98.33% - 99.81%Forma y color:SolidPeso molecular:265.3Loureirin B
CAS:Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Fórmula:C18H20O5Pureza:99.33% - 99.86%Forma y color:White SolidPeso molecular:316.35TOMATIDINE HYDROCHLORIDE
CAS:Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.Fórmula:C27H46ClNO2Pureza:99.75% - ≥95%Forma y color:White SolidPeso molecular:452.11Actein
CAS:Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.Fórmula:C37H56O11Pureza:98% - ≥98%Forma y color:White SolidPeso molecular:676.83Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Fórmula:C44H70O16Pureza:98% - 99.36%Forma y color:SolidPeso molecular:855.02Ro 31-8220 Mesylate
CAS:Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.Fórmula:C25H23N5O2S·CH4O3SPureza:98.79% - 99.02%Forma y color:Orange SolidPeso molecular:553.65Ref: TM-T6643
1mg49,00€2mg64,00€5mg92,00€1mL*10mM (DMSO)133,00€10mg150,00€25mg230,00€50mg319,00€100mg475,00€Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Fórmula:C21H28O2Pureza:99.4% - 99.8%Forma y color:SolidPeso molecular:312.45Ref: TM-T5574
1mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg93,00€25mg152,00€50mg205,00€100mg289,00€200mg432,00€JNK-IN-7
CAS:JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).Fórmula:C28H27N7O2Pureza:98.02% - 99.53%Forma y color:White SolidPeso molecular:493.56Ref: TM-T3598
1mg93,00€2mg149,00€5mg215,00€1mL*10mM (DMSO)233,00€10mg275,00€25mg495,00€50mg712,00€100mg973,00€CC-401 Hydrochloride
CAS:CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Fórmula:C22H25ClN6OPureza:99.71% - ≥95%Forma y color:White SolidPeso molecular:424.93JIP-1 (153-163) acetate(438567-88-5 free base)
JNK peptide inhibitor. Mimics JIP-1 residues 153-163. Micromolar affinity, little effect on p38, ERK.Fórmula:C63H108N20O16Pureza:92.89%Forma y color:SolidPeso molecular:1401.65Ro 31-8220
CAS:Ro 31-8220: potent PKC inhibitor (IC50: 5-27 nM). Affects MAPKAP-K1b, MSK1, S6K1, GSK3β (IC50: 3-38 nM), not MKK3/4/6/7.Fórmula:C25H23N5O2SForma y color:SolidPeso molecular:457.55Bentamapimod
CAS:Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.Fórmula:C25H23N5O2SPureza:97.04% - 99.92%Forma y color:SolidPeso molecular:457.55Ref: TM-T2675
2mg43,00€5mg63,00€10mg94,00€25mg154,00€50mg187,00€100mg333,00€500mg1.089,00€1g1.972,00€2g2.655,00€
