JNK
Las JNK (c-Jun N-terminal kinases) son un subgrupo de la familia MAPK que responden a estímulos de estrés, como citoquinas, radiación ultravioleta y choque térmico, y están involucradas en el control de la apoptosis, la inflamación y las respuestas inmunitarias. La señalización de JNK es crucial para la regulación de las respuestas celulares al estrés y se ha implicado en diversas enfermedades, incluidas las neurodegenerativas, el cáncer y las afecciones inflamatorias. En CymitQuimica, ofrecemos una gama de moduladores de la vía JNK para apoyar su investigación en señalización de estrés, apoptosis y patología de enfermedades.
Se han encontrado 97 productos de "JNK"
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Taurochenodeoxycholic Acid
CAS:<p>Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.</p>Fórmula:C26H45NO6SPureza:99.53% - 99.86%Forma y color:SolidPeso molecular:499.7DB07268
CAS:<p>DB07268 is a potent and selective JNK1 inhibitor.</p>Fórmula:C17H15N5O2Pureza:98.2% - 98.91%Forma y color:SolidPeso molecular:321.33SP600125
CAS:<p>SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive</p>Fórmula:C14H8N2OPureza:97.63% - 99.82%Forma y color:SolidPeso molecular:220.23BI-78D3
CAS:<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Fórmula:C13H9N5O5S2Pureza:97.89% - >99.99%Forma y color:SolidPeso molecular:379.37Anisomycin
CAS:<p>Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.</p>Fórmula:C14H19NO4Pureza:98.33% - 99.81%Forma y color:White Crystalline SolidPeso molecular:265.3Loureirin B
CAS:<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Fórmula:C18H20O5Pureza:99.33% - 99.86%Forma y color:SolidPeso molecular:316.35TOMATIDINE HYDROCHLORIDE
CAS:<p>Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.</p>Fórmula:C27H46ClNO2Pureza:99.75% - ≥95%Forma y color:SolidPeso molecular:452.11Actein
CAS:<p>Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.</p>Fórmula:C37H56O11Pureza:≥98%Forma y color:Brown PowderPeso molecular:676.83Polyphyllin I
CAS:<p>Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,</p>Fórmula:C44H70O16Pureza:98% - 99.5%Forma y color:SolidPeso molecular:855.02Ro 31-8220 Mesylate
CAS:<p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>Fórmula:C25H23N5O2S·CH4O3SPureza:98.79% - 99.02%Forma y color:SolidPeso molecular:553.65Guggulsterone
CAS:<p>Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.</p>Fórmula:C21H28O2Pureza:99.4% - 99.8%Forma y color:Light Yellow PowderPeso molecular:312.45JNK-IN-7
CAS:<p>JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).</p>Fórmula:C28H27N7O2Pureza:98.02% - 99.53%Forma y color:SolidPeso molecular:493.56CC-401 Hydrochloride
CAS:<p>CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.</p>Fórmula:C22H25ClN6OPureza:99.71% - ≥95%Forma y color:SolidPeso molecular:424.93Bentamapimod
CAS:<p>Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.</p>Fórmula:C25H23N5O2SPureza:97.04% - 99.92%Forma y color:SolidPeso molecular:457.55Astragaloside IV
CAS:<p>Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.</p>Fórmula:C41H68O14Pureza:99% - 99.84%Forma y color:Hydroscopic Brown Or Yellow PowderPeso molecular:784.97JNK-IN-8
CAS:<p>JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).</p>Fórmula:C29H29N7O2Pureza:99.24% - >99.99%Forma y color:SolidPeso molecular:507.59Epieriocalyxin A
CAS:<p>Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.</p>Fórmula:C20H24O5Pureza:97.00%Forma y color:SolidPeso molecular:344.4Isovitexin
CAS:<p>1.</p>Fórmula:C21H20O10Pureza:99.79% - 99.97%Forma y color:SolidPeso molecular:432.38IQ-3
CAS:<p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>Fórmula:C20H11N3O3Pureza:≥98%Forma y color:SolidPeso molecular:341.32Indirubin-3′-oxime
CAS:<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Fórmula:C16H11N3O2Pureza:98.34%Forma y color:SolidPeso molecular:277.28
