JNK
Las JNK (c-Jun N-terminal kinases) son un subgrupo de la familia MAPK que responden a estímulos de estrés, como citoquinas, radiación ultravioleta y choque térmico, y están involucradas en el control de la apoptosis, la inflamación y las respuestas inmunitarias. La señalización de JNK es crucial para la regulación de las respuestas celulares al estrés y se ha implicado en diversas enfermedades, incluidas las neurodegenerativas, el cáncer y las afecciones inflamatorias. En CymitQuimica, ofrecemos una gama de moduladores de la vía JNK para apoyar su investigación en señalización de estrés, apoptosis y patología de enfermedades.
Se han encontrado 105 productos para "JNK".
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TOMATIDINE HYDROCHLORIDE
CAS:Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.Fórmula:C27H46ClNO2Pureza:99.75% - ≥95%Forma y color:White SolidPeso molecular:452.11Actein
CAS:Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.Fórmula:C37H56O11Pureza:98% - ≥98%Forma y color:White SolidPeso molecular:676.83Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Fórmula:C44H70O16Pureza:98% - 99.36%Forma y color:SolidPeso molecular:855.02Ro 31-8220 Mesylate
CAS:Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.Fórmula:C25H23N5O2S·CH4O3SPureza:98.79% - 99.02%Forma y color:Orange SolidPeso molecular:553.65Ref: TM-T6643
1mg49,00€2mg64,00€5mg92,00€1mL*10mM (DMSO)133,00€10mg150,00€25mg230,00€50mg319,00€100mg475,00€Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Fórmula:C21H28O2Pureza:99.4% - 99.8%Forma y color:SolidPeso molecular:312.45Ref: TM-T5574
1mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg93,00€25mg152,00€50mg205,00€100mg289,00€200mg432,00€JNK-IN-7
CAS:JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).Fórmula:C28H27N7O2Pureza:98.02% - 99.53%Forma y color:White SolidPeso molecular:493.56Ref: TM-T3598
1mg93,00€2mg149,00€5mg215,00€1mL*10mM (DMSO)233,00€10mg275,00€25mg495,00€50mg712,00€100mg973,00€CC-401 Hydrochloride
CAS:CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Fórmula:C22H25ClN6OPureza:99.71% - ≥95%Forma y color:White SolidPeso molecular:424.93JIP-1 (153-163) acetate(438567-88-5 free base)
JNK peptide inhibitor. Mimics JIP-1 residues 153-163. Micromolar affinity, little effect on p38, ERK.Fórmula:C63H108N20O16Pureza:92.89%Forma y color:SolidPeso molecular:1401.65Ro 31-8220
CAS:Ro 31-8220: potent PKC inhibitor (IC50: 5-27 nM). Affects MAPKAP-K1b, MSK1, S6K1, GSK3β (IC50: 3-38 nM), not MKK3/4/6/7.Fórmula:C25H23N5O2SForma y color:SolidPeso molecular:457.55Bentamapimod
CAS:Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.Fórmula:C25H23N5O2SPureza:97.04% - 99.92%Forma y color:SolidPeso molecular:457.55Ref: TM-T2675
2mg43,00€5mg63,00€10mg94,00€25mg154,00€50mg187,00€100mg333,00€500mg1.089,00€1g1.972,00€2g2.655,00€Astragaloside IV
CAS:Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.Fórmula:C41H68O14Pureza:99% - 99.84%Forma y color:SolidPeso molecular:784.97JNK-IN-8
CAS:JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Fórmula:C29H29N7O2Pureza:99.24% - >99.99%Forma y color:White SolidPeso molecular:507.59Ref: TM-T2668
2mg44,00€5mg73,00€1mL*10mM (DMSO)82,00€10mg113,00€25mg197,00€50mg326,00€100mg482,00€200mg685,00€Epieriocalyxin A
CAS:Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.Fórmula:C20H24O5Pureza:97.00%Forma y color:SolidPeso molecular:344.4D-JNKI-1 acetate
D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.Fórmula:C166H290N66O42Pureza:99.48%Forma y color:SolidPeso molecular:3882.5Ref: TM-T10937L
1mg156,00€5mg296,00€10mg442,00€25mg707,00€50mg1.009,00€1mL*10mM (DMSO)1.089,00€100mg1.333,00€TRi-1
CAS:TRi-1 irreversibly inhibits TXNRD1 (IC50: 12 nM) with low mitochondrial toxicity for cancer treatment.Fórmula:C12H9ClN2O5SPureza:97.14%Forma y color:SolidPeso molecular:328.73Ref: TM-T5481
1mg70,00€2mg89,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg205,00€25mg340,00€50mg485,00€100mg700,00€Ref: TM-T6S1371
1mg49,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg133,00€25mg259,00€50mg358,00€100mg530,00€200mg755,00€IQ-3
CAS:IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.Fórmula:C20H11N3O3Pureza:≥98%Forma y color:White SolidPeso molecular:341.32Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Fórmula:C16H11N3O2Pureza:98.34%Forma y color:SolidPeso molecular:277.28Ref: TM-T9138
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg120,00€25mg236,00€50mg356,00€100mg532,00€200mg772,00€IQ-1S free acid
CAS:IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.Fórmula:C15H9N3OPureza:97.92% - 99.05%Forma y color:SolidPeso molecular:247.25Ref: TM-T3627
5mg44,00€1mL*10mM (DMSO)48,00€10mg50,00€25mg90,00€50mg160,00€100mg289,00€200mg430,00€500mg695,00€Taurochenodeoxycholic acid sodium
CAS:Sodium taurochenodeoxycholate: induces apoptosis, anti-inflammatory, boosts insulin, stimulates α2-cells, increases [Ca(2+)](c).Fórmula:C26H44NNaO6SPureza:98.23% - 99.56%Forma y color:White SolidPeso molecular:521.68Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Forma y color:White SolidPeso molecular:327.83CC-90001
CAS:CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Fórmula:C16H27N5O2Pureza:99.96%Forma y color:White SolidPeso molecular:321.42Esculentoside H
CAS:Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.Fórmula:C48H76O21Pureza:98.9% - 99.3%Forma y color:White SolidPeso molecular:989.1TCS JNK 5a
CAS:TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).Fórmula:C20H16N2OSPureza:99.22% - 99.51%Forma y color:SolidPeso molecular:332.42Ginsenoside Re
CAS:Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Fórmula:C48H82O18Pureza:99.12% - >99.99%Forma y color:SolidPeso molecular:947.15Ref: TM-T2872
2mg34,00€5mg48,00€10mg63,00€1mL*10mM (DMSO)65,00€25mg92,00€50mg138,00€100mg197,00€200mg290,00€Tomatidine
CAS:Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.Fórmula:C27H45NO2Pureza:99.94% - 99.98%Forma y color:White SolidPeso molecular:415.65Sesamolin
CAS:Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.Fórmula:C20H18O7Pureza:98.77% - 99.04%Forma y color:White SolidPeso molecular:370.35Ref: TM-T5S2283
1mg35,00€2mg50,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg120,00€25mg197,00€50mg294,00€100mg437,00€200mg622,00€Pamapimod
CAS:Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.Fórmula:C19H20F2N4O4Pureza:99.52% - 99.99%Forma y color:SolidPeso molecular:406.38SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Fórmula:C29H25FN4O4Pureza:98%Forma y color:SolidPeso molecular:512.53SX 011
CAS:SX 011 is a p38α inhibitor.Fórmula:C26H27ClFN3O3Pureza:98%Forma y color:SolidPeso molecular:483.96TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFórmula:C17H15F3N2O4Forma y color:SolidPeso molecular:368.31BSJ-04-122
CAS:BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Fórmula:C15H12ClN5OPureza:98.09%Forma y color:SolidPeso molecular:313.74SR 3576
CAS:JNK3 inhibitor, potent and selectiveFórmula:C27H27N5O5Pureza:98%Forma y color:SolidPeso molecular:501.53GSK649A
CAS:GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Fórmula:C15H12ClFN6OSPureza:98%Forma y color:SolidPeso molecular:378.81J30-8
CAS:J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Fórmula:C17H9ClFN3O2SPureza:99.90%Forma y color:Red SolidPeso molecular:373.79ZG-10
CAS:ZG-10 (JNK-IN-2) is an inhibitor of JNK, blocking JNK1, JNK2, and JNK3, and is used in studies of SARS-CoV-2 virus infection.Fórmula:C28H27N7O2Pureza:99.41% - 99.91%Forma y color:Yellow SolidPeso molecular:493.56JNK3 inhibitor-4
CAS:JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.Fórmula:C28H27N7OForma y color:SolidPeso molecular:477.56SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Fórmula:C28H26N8OPureza:99.38% - 99.71%Forma y color:SolidPeso molecular:490.56Ref: TM-T16927
1mg49,00€5mg98,00€1mL*10mM (DMSO)108,00€10mg152,00€25mg288,00€50mg520,00€100mg835,00€500mg1.674,00€JNK-1-IN-1
CAS:JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Fórmula:C24H22N6SForma y color:SolidPeso molecular:426.54JNK-IN-11
CAS:JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Fórmula:C12H11NO3S2Pureza:99.24%Forma y color:Yellow SolidPeso molecular:281.35Ezatiostat hydrochloride
CAS:Ezatiostat HCl (TLK199) inhibits glutathione S-transferase, GSTP1-1 specifically, and may treat cytopenias.Fórmula:C27H36ClN3O6SPureza:98%Forma y color:SolidPeso molecular:566.11Ref: TM-T22776
2mg55,00€5mg78,00€1mL*10mM (DMSO)112,00€10mg114,00€25mg190,00€50mg290,00€100mg490,00€200mg735,00€500mg1.104,00€JNK3 inhibitor-1
CAS:JNK3 inhibitor-1: potent, selective, IC50 of 0.005 μM, orally bioavailable, brain-penetrant.Fórmula:C21H17ClFN5O2SForma y color:SolidPeso molecular:457.91JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Fórmula:C26H25N7O2Pureza:98%Forma y color:SolidPeso molecular:467.52TC ASK 10
CAS:TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.Fórmula:C21H23Cl2N5OPureza:99.86%Forma y color:SolidPeso molecular:432.35Ref: TM-T13099
1mg33,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg124,00€25mg236,00€50mg371,00€100mg532,00€200mg705,00€Nitric oxide production-IN-11k
CAS:Nitric oxide production-IN-11k is a compound that inhibits TLR4, JNK, and NF-κB signaling pathways.Fórmula:C23H20O3Forma y color:SolidPeso molecular:344.403p38 Kinase inhibitor 8
CAS:p38 Kinase inhibitor 8 (Compound CCLXXVIII) is an orally active inhibitor targeting p38β and JNK2α2, with IC50 values of 6.3 nM and 53.6 nM, respectively. It has demonstrated anti-inflammatory effects in a rat model of collagen-induced arthritis.Fórmula:C22H21FN6O2Forma y color:SolidPeso molecular:420.44JNK-1-IN-4
CAS:JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA). JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.Fórmula:C22H25BrN6O3Forma y color:SolidPeso molecular:501.38PT109
CAS:PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.Fórmula:C23H31N3OS2Forma y color:SolidPeso molecular:429.64JNK-IN-21
CAS:JNK-IN-21 (Compound 62) is an inhibitor of JNK-1.Fórmula:C19H16N2O2SForma y color:SolidPeso molecular:336.408JD118
CAS:JD118 is an inhibitor of JNK. It effectively suppresses the activity of JNK1 and the expression of cJun (1 - 135).Fórmula:C13H12N4S2Forma y color:SolidPeso molecular:288.391
