MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 893 productos de "MAPK"
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EO-1606
CAS:<p>EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.</p>Fórmula:C21H17ClFNOPureza:98.28% - 98.84%Forma y color:SolidPeso molecular:353.82p38α inhibitor 4
CAS:p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.Fórmula:C14H7F6N3OPureza:99.69%Forma y color:SolidPeso molecular:347.215AKP-001
CAS:AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in the study of immune and digestive disorders.Fórmula:C21H13ClF2N4O2Pureza:99.50% - 99.92%Forma y color:SolidPeso molecular:426.8p38 MAPK Inhibitor
CAS:<p>p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.</p>Fórmula:C20H13ClFN3OPureza:99.91%Forma y color:SolidPeso molecular:365.79Cot inhibitor-1
CAS:Cot inhibitor-1 selectively blocks Tpl2 kinase, reducing TNF-alpha in blood (IC50: 5.7 nM). It may treat arthritis, IBD, and certain cancers.Fórmula:C27H27Cl2FN8Pureza:98.87%Forma y color:SolidPeso molecular:553.46NMDAR/TRPM4-IN-2
CAS:Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.Fórmula:C11H19BrCl2N2Pureza:99.75%Forma y color:SolidPeso molecular:330.092SOS1-IN-15
CAS:<p>SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.</p>Fórmula:C28H27F3N6O2Pureza:98.32%Forma y color:SolidPeso molecular:536.548B-Raf IN 5
CAS:B-Raf IN 5 is a potent inhibitor of the protein kinase B-Raf (IC50: 2.0 nM). B-Raf IN 5 resists rapid metabolism and does not bind to the secondary target PXR.Fórmula:C23H18ClF3N6O3S2Forma y color:SolidPeso molecular:583.01KRAS G12C inhibitor 49
CAS:KRAS G12C inhibitor 49 is an orally active KRAS G12C inhibitor that exhibits antitumour effects.Fórmula:C31H31ClN6O3Forma y color:SolidPeso molecular:571.07SOS1-IN-5
CAS:<p>SOS1-IN-5, a potent pyrimidine inhibitor, disrupts RAS-SOS1, blocking KRAS activation.</p>Fórmula:C26H31F3N4O5Forma y color:SolidPeso molecular:536.54KRAS inhibitor-12
CAS:KRAS inhibitor-12 blocks KRAS G12C (IC50: 0.537 μM) and p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancer study.Fórmula:C19H16Cl2FN5OSForma y color:SolidPeso molecular:452.33Ras inhibitor 134
CAS:Ras inhibitor 134 can be used in studies about Ras.Fórmula:C23H21ClFN5O3Forma y color:SoildPeso molecular:469.9SOS1-IN-8
CAS:SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM).Fórmula:C24H26F3N3O4Forma y color:SolidPeso molecular:477.48KRAS G12C mutant protein inhibitor A-1
CAS:KRAS G12C mutant protein inhibitor A-1 can be used in studies about Ras.Fórmula:C31H26ClF4N7O2Forma y color:SolidPeso molecular:640.03ERK1/2 inhibitor 7
CAS:ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).Fórmula:C23H22FN7OSForma y color:SolidPeso molecular:463.53GGTI-297
CAS:GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase).Fórmula:C26H31N3O3SForma y color:SolidPeso molecular:465.61SOS1-IN-14
CAS:SOS1-IN-14 是选择性的、有效的、口服具有活力的 SOS1 抑制剂 (IC50: 3.9 nM)。SOS1-IN-14 能够利用 P-糖蛋白介导的外排机制在肠道内被吸收。SOS1-IN-14 能够用于 KRAS 突变的癌症的研究，且抑瘤效果比 BI-3406 好。Fórmula:C29H29F3N6O2Forma y color:SolidPeso molecular:550.57CMP3a
CAS:CMP3a, a NEK2 inhibitor, hinders GBM in mice and enhances radiotherapy by disrupting EZH2.Fórmula:C28H27F3N6O2SForma y color:SolidPeso molecular:568.61AMG-548 hydrochloride (864249-60-5 free base)
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selectiveFórmula:C29H28ClN5OPureza:98%Forma y color:SolidPeso molecular:498.02SOS1-IN-16
CAS:SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 ofFórmula:C30H31F3N4O3Pureza:98%Forma y color:SolidPeso molecular:552.59KRAS inhibitor-18
CAS:KRAS inhibitor-18 targets KRAS G12C; IC50: 4.74 μM. Inhibits p-ERK in cancer cells. Promising for pancreatic, colorectal, lung cancer research.Fórmula:C20H15ClF3N3O2SForma y color:SolidPeso molecular:453.87HPK1-IN-27
CAS:HPK1-IN-27 inhibits HPK1 (MAP4K1), a kinase with potential for cancer treatment, per patent WO2019016071A1, compound 38.Fórmula:C26H23F3N4O4Forma y color:SolidPeso molecular:512.48ZG1077
CAS:ZG1077, a covalent KRAS G12C inhibitor, is utilized in non-small cell lung cancer (NSCLC) research.Fórmula:C33H33F2N5O5SForma y color:SolidPeso molecular:649.71SOS1-IN-4
CAS:SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.Fórmula:C24H29F2N4O2PForma y color:SolidPeso molecular:474.48KRAS G12C inhibitor 35
CAS:KRAS G12C inhibitor 35 targets KRAS G12C in cancer research (CN112920183A, compound 3).Fórmula:C31H27ClF2N6O3Forma y color:SolidPeso molecular:605.03KRAS G12C inhibitor 21
CAS:KRAS G12C inhibitor 21 is a KRAS G12C inhibitor.Fórmula:C34H30ClN3O4Forma y color:SolidPeso molecular:580.07TH-Z827
CAS:<p>TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).</p>Fórmula:C30H38N6OPureza:98%Forma y color:SolidPeso molecular:498.66HPK1-IN-9
CAS:HPK1-IN-9: Potent MAP4K family kinase inhibitor targeting hematopoietic progenitor cells; potential in HPK1 diseases. (Patent WO2021213317A1)Fórmula:C30H33N7O2Forma y color:SolidPeso molecular:523.63Uplarafenib
CAS:Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.Fórmula:C22H21F3N4O4SPureza:99.98%Forma y color:SolidPeso molecular:494.49DL-threo dihydrosphingosine
CAS:DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.Fórmula:C18H39NO2Forma y color:SolidPeso molecular:301.51Inflachromene
CAS:Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.Fórmula:C21H19N3O4Pureza:97.36% - 99.88%Forma y color:SolidPeso molecular:377.39MS934
CAS:<p>MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.</p>Fórmula:C52H69F3IN7O6SPureza:98%Forma y color:SolidPeso molecular:1104.11KRAS G12C inhibitor 25
CAS:KRAS G12C inhibitor 25 blocks SOS1-mediated GDP/GTP swap in KRAS-G12C mutants; IC50: 0.48 nM (WO2021216770A1, comp. 3).Fórmula:C32H41N7O2Forma y color:SolidPeso molecular:555.71HPK1-IN-33
CAS:HPK1-IN-33 inhibits HPK1 with 1.7 nM potency, reduces IL-2 in Jurkat cells with 286 nM EC50, and is less effective in HPK1 KO cells.Fórmula:C18H16ClFN6Forma y color:SolidPeso molecular:370.81L 731734
CAS:L 731734 is a farnesyltransferase inhibitor.Fórmula:C19H38N4O3SForma y color:SolidPeso molecular:402.6KRAS G12C inhibitor 53
CAS:KRAS G12C inhibitor 53 (Compound 1) is a KRAS G12C inhibitor.Fórmula:C21H14ClF2N5O2Forma y color:SolidPeso molecular:441.82HPK1-IN-11
CAS:HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.Fórmula:C27H25N5O2Forma y color:SolidPeso molecular:451.52KRAS G12C inhibitor 32
CAS:KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].Fórmula:C29H30Cl3FN6O3Pureza:98%Forma y color:SolidPeso molecular:635.94HPK1-IN-13
CAS:HPK1-IN-13 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.Fórmula:C25H24FN5O2Forma y color:SolidPeso molecular:445.49Glecirasib
CAS:Glecirasib (JAB-21822,KRAS G12C inhibitor 36) is an orally active KRAS G12C inhibitor that selectively binds to and inhibits KRAS G12C-dependent signalingFórmula:C31H26ClF4N7O2Pureza:99.7% - >99.99%Forma y color:SolidPeso molecular:640.03KRAS G12C inhibitor 30
CAS:KRAS G12C inhibitor 30 is an inhibitor of KRAS G12C and can be used to study cancer.Fórmula:C25H22ClFN6O3Forma y color:SolidPeso molecular:508.93Pan-RAF kinase inhibitor 1
CAS:Potent Pan-RAF inhibitor 1 targets RAF/MAPK pathway, curbing RAS-mutated cancer cell growth. (Patent WO2021110141A1, compound 16B)Fórmula:C26H24F3N3O4Forma y color:SolidPeso molecular:499.48KRAS G12C inhibitor 51
CAS:KRAS G12C inhibitor 51 is a KRAS G12C inhibitor.Fórmula:C33H35FN6O3Forma y color:SolidPeso molecular:582.67HPK1-IN-10
CAS:HPK1-IN-10 inhibits HPK1, a MAP4K kinase from progenitor cells, with potential in treating HPK1 diseases, detailed in patent WO2021213317A1.Fórmula:C31H34N6O2Forma y color:SolidPeso molecular:522.64SOS1/KRAS-IN-1
CAS:SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].Fórmula:C24H26F3N5OPureza:98%Forma y color:SolidPeso molecular:457.49GNE 220 hydrochloride
CAS:<p>GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).</p>Fórmula:C25H27ClN8Forma y color:SolidPeso molecular:474.99Org OD 02-0
CAS:10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activateFórmula:C22H30O2Pureza:98%Forma y color:SolidPeso molecular:326.47B-Raf IN 15
CAS:<p>B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.</p>Fórmula:C19H15N3OSPureza:98%Forma y color:SolidPeso molecular:333.41FGTI-2734 mesylate (1247018-19-4 free base)
CAS:FGTI-2734 mesylate hinders KRAS, overcoming resistance and targeting pancreatic tumors; inhibits FT and GGT with IC50s of 250 nM, 520 nM.Fórmula:C27H35FN6O5S2Pureza:98%Forma y color:SolidPeso molecular:606.73ERK-IN-2 free base
CAS:ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.Fórmula:C16H17N5O2Forma y color:SolidPeso molecular:311.34CXJ-2
CAS:CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.Fórmula:C55H87N15O22Pureza:98%Forma y color:SolidPeso molecular:1310.37(R)-BDP9066
CAS:(R)-BDP9066 blocks MRCK to curb cancer cell spread, aiding research on diseases like cancer.Fórmula:C20H24N6Forma y color:SolidPeso molecular:348.44KRAS G12C inhibitor 61
CAS:KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.Fórmula:C31H33ClFN7O2Pureza:98%Forma y color:SolidPeso molecular:590.09Ilaprazole sodium hydrate
CAS:Ilaprazole sodium hydrate (IY-81149 sodium hydrate) is a proton pump inhibitor that blocks the transport of HSV particles.Fórmula:C19H21N4NaO4SPureza:99.2%Forma y color:SolidPeso molecular:424.45ERK1/2 inhibitor 5
CAS:ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Fórmula:C28H32ClFN6O5Forma y color:SolidPeso molecular:587.04Laxiflorin B
CAS:Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].Fórmula:C20H24O5Pureza:98%Forma y color:SolidPeso molecular:344.4K-Ras G12C-IN-2
CAS:K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.Fórmula:C21H27ClN4O3Pureza:98%Forma y color:SolidPeso molecular:418.92KRAS G12C inhibitor 40
CAS:KRAS G12C inhibitor 40 targets KRAS G12C in cancer research (WO2021129824A1, compound 70).Fórmula:C34H36ClFN10O2Forma y color:SolidPeso molecular:671.17FGTI-2734
CAS:<p>FGTI-2734, a dual FT/GGT-1 inhibitor (IC50: 250/520 nM), blocks KRAS membrane binding and curbs KRAS-driven pancreatic cancer.</p>Fórmula:C26H31FN6O2SPureza:99.69%Forma y color:SolidPeso molecular:510.63BDP8900
CAS:BDP8900: potent, selective MRCK inhibitor; alters cancer cell shape, reduces mobility and invasion.Fórmula:C19H23N5SForma y color:SolidPeso molecular:353.48p38 Kinase inhibitor 4
CAS:Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].Fórmula:C12H9Cl2N3OPureza:98%Forma y color:SolidPeso molecular:282.13B-Raf IN 16
CAS:<p>B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.</p>Fórmula:C20H19N5O3SPureza:99.31% - 99.78%Forma y color:SolidPeso molecular:409.46GNE 220
CAS:GNE-220 is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).Fórmula:C25H26N8Pureza:98%Forma y color:SolidPeso molecular:438.53HPK1-IN-12
CAS:HPK1-IN-12 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.Fórmula:C25H24FN5O2Forma y color:SolidPeso molecular:445.49XRP44X
CAS:XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.Fórmula:C21H21ClN4OPureza:99.67%Forma y color:SolidPeso molecular:380.87MNK inhibitor 9
CAS:<p>MNK inhibitor 9 potently blocks MNK1/2 (IC50: 0.003 µM each), is cell-permeable, and useful for tumor research.</p>Fórmula:C25H29N9OForma y color:SolidPeso molecular:471.56KRAS inhibitor-11
KRAS inhibitor-11 is a KRAS inhibitor .Fórmula:C29H47N9O6Forma y color:SolidPeso molecular:617.74RO4927350
CAS:RO4927350 is a potent, selective MEK1/2 inhibitor, blocking MAPK pathway in vitro/vivo and showing notable antitumor effects.Fórmula:C27H28N4O6SForma y color:SolidPeso molecular:536.6ERK1/2 inhibitor 9
CAS:ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates theFórmula:C31H32ClN7O3Pureza:98%Forma y color:SolidPeso molecular:586.08GSK1790627
CAS:GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].Fórmula:C24H21FIN5O3Forma y color:SolidPeso molecular:573.36RAF mutant-IN-1
CAS:RAF mutant-IN-1 is an inhibitor of RAF kinase(IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively).Fórmula:C23H18Cl3FN6O2SPureza:98%Forma y color:SolidPeso molecular:567.85ERK Inhibitor II (Negative control)
CAS:ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.Fórmula:C18H12N6OForma y color:SolidPeso molecular:328.33AZD4747
CAS:<p>AZD4747 is an inhibitor of the mutant GTPase KRASG12C that hasial antitumor activity for the study of pancreatic and colorectal adenocarcinoma.</p>Fórmula:C24H22ClFN2O3Pureza:99.36%Forma y color:SolidPeso molecular:440.89KRAS G12C inhibitor 14
CAS:KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].Fórmula:C24H19ClF2N4O3Pureza:98%Forma y color:SolidPeso molecular:484.88Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Fórmula:C18H19FN8O2SPureza:98%Forma y color:SolidPeso molecular:430.46KRAS G12C inhibitor 13
CAS:<p>KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .</p>Fórmula:C40H46F3N7O4Pureza:98%Forma y color:SolidPeso molecular:745.83RPR203494
CAS:RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.Fórmula:C26H29FN6O4Forma y color:SolidPeso molecular:508.54HPK1-IN-37
CAS:HPK1-IN-37 (compound A85), with an IC50 value of 3.7 nM, is a potent inhibitor of HPK1.Fórmula:C27H35N7O4Forma y color:SolidPeso molecular:521.61PROTAC KRAS G12C degrader-3
CAS:PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].Fórmula:C63H75ClN14O6Pureza:98%Forma y color:SolidPeso molecular:1159.81ERK1/2 inhibitor 8
CAS:ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).Fórmula:C23H20ClN7O2SForma y color:SolidPeso molecular:493.97Deltasonamide 1
CAS:Deltasonamide is a potent and selective inhibitor of PDE6δ‐KRas.Fórmula:C30H39ClN6O4S2Forma y color:SolidPeso molecular:647.25(aS)-PH-797804
CAS:(aS)-PH-797804 is a selective inhibitor of p38 MAPK, demonstrating inhibitory concentration (IC50) values of 26 nM for p38α and 102 nM for p38β. This compound exhibits anti-inflammatory activity [1] [2].Fórmula:C22H19BrF2N2O3Forma y color:SolidPeso molecular:477.3KRas G12C inhibitor 1
CAS:KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.Fórmula:C31H38N6O3Pureza:98%Forma y color:SolidPeso molecular:542.67TNIK&MAP4K4-IN-1
CAS:TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and <10 nM, respectively, in humanFórmula:C25H23FN4O3Forma y color:SolidPeso molecular:446.47KRAS G12C inhibitor 34
CAS:KRAS G12C inhibitor 34 is an inhibitor of KRAS G12C that can be used to study cancer research.Fórmula:C32H32ClN5O3Forma y color:SolidPeso molecular:570.08JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Fórmula:C26H25N7O2Pureza:98%Forma y color:SolidPeso molecular:467.52MEK-IN-6 hydrate
CAS:MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].Fórmula:C18H22FN3O5SPureza:98%Forma y color:SolidPeso molecular:411.45MEK-IN-6
CAS:MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making itFórmula:C18H20FN3O4SPureza:98%Forma y color:SolidPeso molecular:393.43KRAS G12C inhibitor 5
CAS:KRAS G12C inhibitor 5 is a KRas G12C inhibitor.Fórmula:C32H37N7O2Pureza:98%Forma y color:SolidPeso molecular:551.68pan-KRAS-IN-4
CAS:Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Fórmula:C36H34F2N6O3Pureza:98%Forma y color:SolidPeso molecular:636.69SKF-86002 dihydrochloride
CAS:<p>p38 MAP kinase inhibitor</p>Fórmula:C16H14Cl2FN3SPureza:98%Forma y color:SolidPeso molecular:370.27K-Ras G12C-IN-1
CAS:K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.Fórmula:C22H23Cl2N3O3Forma y color:SolidPeso molecular:448.34pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Fórmula:C33H32F3N5O2Pureza:98%Forma y color:SolidPeso molecular:587.63SB 203580 sulfone
CAS:<p>SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].</p>Fórmula:C21H16FN3O2SForma y color:SolidPeso molecular:393.43AZ-TAK1
CAS:"AZ-Tak1 inhibits TAK1 kinase (IC50=0.009mM), reduces p38/ERK levels, and induces apoptosis in Mino, SP53, Jeko cells with increasing efficacy at 0.1-0.5mM."Fórmula:C25H28FN7O2Forma y color:SolidPeso molecular:477.53HPK1-IN-35
CAS:HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM.Fórmula:C30H32N8O3SForma y color:SolidPeso molecular:584.69AMG-548 dihydrochloride (864249-60-5 free base)
AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; >> p38γ/δ; blocks LPS-induced TNFα, IC50: 3 nM.Fórmula:C29H29Cl2N5OPureza:98%Forma y color:SolidPeso molecular:534.48Rac1-IN-3
CAS:Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].Fórmula:C21H23N7O2Pureza:98%Forma y color:SolidPeso molecular:405.45BI-0474
CAS:<p>BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells & lung cancer model, for cancer research.</p>Fórmula:C30H37N9O2SPureza:99.61%Forma y color:SolidPeso molecular:587.74(R)-VX-11e
CAS:(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.Fórmula:C24H20Cl2FN5O2Pureza:98.73%Forma y color:SolidPeso molecular:500.35
