MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 886 productos de "MAPK"
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Neflamapimod
CAS:<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Fórmula:C19H9Cl2F2N3OSPureza:97.88% - 99.75%Forma y color:SolidPeso molecular:436.26Belvarafenib TFA
<p>Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.</p>Fórmula:C25H17ClF4N6O3SForma y color:SolidPeso molecular:592.95K-Ras-IN-1
CAS:<p>K-Ras-IN-1 is a K-Ras inhibitor.</p>Fórmula:C11H13NOSPureza:98.72%Forma y color:SolidPeso molecular:207.29KRPEP-2D acetate
<p>KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.</p>Fórmula:C110H186N44O27S2Pureza:98.94%Forma y color:SolidPeso molecular:2621.06JNK-IN-8
CAS:<p>JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).</p>Fórmula:C29H29N7O2Pureza:99.24% - >99.99%Forma y color:SolidPeso molecular:507.59SUN11602
CAS:<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Fórmula:C26H37N5O2Pureza:99.36%Forma y color:SolidPeso molecular:451.66H05 (TFA)
CAS:<p>6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.</p>Fórmula:C22H31ClF3N3O4S3Pureza:98.83%Forma y color:SolidPeso molecular:590.14ML-098
CAS:<p>ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).</p>Fórmula:C19H19NO3Pureza:99.06% - 99.23%Forma y color:SolidPeso molecular:309.36MK2-IN-3
CAS:<p>MK2-IN-3 is a potent MK-2 inhibitor, cell-permeable, for rheumatoid arthritis treatment.</p>Fórmula:C21H16N4OPureza:99.01%Forma y color:SolidPeso molecular:340.381-(4-methansulfinylphenyl)ethanone
CAS:<p>The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.</p>Fórmula:C9H10O2SPureza:99.48%Forma y color:SolidPeso molecular:182.24L-779450
CAS:<p>L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.</p>Fórmula:C20H14ClN3OPureza:≥95%Forma y color:SolidPeso molecular:347.8K-Ras(G12C) inhibitor 9
CAS:<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Forma y color:SolidPeso molecular:513.78SD 0006
CAS:<p>SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.</p>Fórmula:C20H20ClN5O2Pureza:98.32%Forma y color:SolidPeso molecular:397.86IACS-13909
CAS:<p>IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.</p>Fórmula:C17H18Cl2N6Pureza:98.8%Forma y color:SolidPeso molecular:377.27CMPD1
CAS:<p>CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).</p>Fórmula:C22H20FNO2Pureza:99.8%Forma y color:SolidPeso molecular:349.4CC-90001
CAS:<p>CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.</p>Fórmula:C16H27N5O2Pureza:99.96%Forma y color:SolidPeso molecular:321.42Dabrafenib Mesylate
CAS:<p>Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).</p>Fórmula:C24H24F3N5O5S3Pureza:99.45% - 99.82%Forma y color:SolidPeso molecular:615.671588-A4
CAS:<p>1588-A4 (ARS-1620 Intermediate) is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.</p>Fórmula:C17H19BrClFN4O2Pureza:98.59%Forma y color:SolidPeso molecular:445.71Varenicline Tartrate
CAS:<p>Varenicline Tartrate (CP 526555-18) is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist.</p>Fórmula:C13H13N3·C4H6O6Pureza:98.23% - 98.32%Forma y color:Tan SolidPeso molecular:361.35Encorafenib
CAS:<p>Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.</p>Fórmula:C22H27ClFN7O4SPureza:99.51% - 99.83%Forma y color:SolidPeso molecular:540.01
