
MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 892 productos de "MAPK"
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JNK3 inhibitor-4
CAS:<p>JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.</p>Fórmula:C28H27N7OForma y color:SolidPeso molecular:477.56HPK1-IN-17
CAS:HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.Fórmula:C26H28N6OForma y color:SolidPeso molecular:440.54KB-5246
CAS:KB-5246, displays antibacterial activities.is a tetracyclic quinolone.Fórmula:C18H17ClFN3O4SPureza:98%Forma y color:SolidPeso molecular:425.86HPK1-IN-15
CAS:HPK1-IN-15 selectively inhibits HPK1, a MAP4K family kinase, potentially aiding in cancer treatment.Fórmula:C24H21ClF3N5Forma y color:SolidPeso molecular:471.91KRAS inhibitor-17
CAS:KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.Fórmula:C21H18Cl2FN3O2SForma y color:SolidPeso molecular:466.36BRAF V600E/CRAF-IN-2
CAS:Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.Fórmula:C30H30F3N5O2Forma y color:SolidPeso molecular:549.59SOS1-IN-12
CAS:SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).Fórmula:C23H26F3N5Forma y color:SolidPeso molecular:429.48MTBT
CAS:MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.Fórmula:C14H11NO2S2Forma y color:SolidPeso molecular:289.37KRAS4b-IN-D14
CAS:KRAS4b-IN-D14 inhibits oncogenic KRAS4b, shrinks tumors, and induces cancer cell apoptosis.Fórmula:C24H24ClN5O4Forma y color:SolidPeso molecular:481.93L-167307
CAS:L-167307 is a p38 kinase inhibitor.Fórmula:C22H17FN2OSPureza:98%Forma y color:SolidPeso molecular:376.45GGTI-286
CAS:GGTI-286: GGTase I inhibitor, cell-permeable, IC50=2μM. Strongly blocks Rap1A geranylation; less effective on H-Ras, Ras4B IC50=1μM.Fórmula:C23H31N3O3SForma y color:SolidPeso molecular:429.58(S)-p38 MAPK Inhibitor III
CAS:(S)-p38 MAPK inhibitor III: a cell-permeable, methylsulfanylimidazole; IC50s: 0.90 µM for p38 MAPK, 0.37 µM TNF-α, 0.044 µM IL-1β.Fórmula:C23H21FN4SForma y color:SolidPeso molecular:404.5DDO3711
CAS:"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."Fórmula:C42H41N9O6Forma y color:SolidPeso molecular:767.83KRAS4b-PDEδ stabilizer C19
CAS:KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis viaFórmula:C18H20Cl2N2O3Forma y color:SolidPeso molecular:383.27B-Raf IN 7
CAS:"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."Fórmula:C15H16N6O3Forma y color:SolidPeso molecular:328.33TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFórmula:C17H15F3N2O4Forma y color:SolidPeso molecular:368.31BRAF V600E/CRAF-IN-1
CAS:BRAF V600E/CRAF-IN-1: potent BRAF/CRAF inhibitor, induces cell cycle arrest and apoptosis in HCT-116 cells, promising for cancer research.Fórmula:C25H17F6N3O2Forma y color:SolidPeso molecular:505.41HPK1-IN-29
CAS:"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."Fórmula:C26H18F3N5O2Forma y color:SolidPeso molecular:489.45SB 204900
CAS:SB 204900 inhibit the release of histamine and TNF-α from RBL-2H3 cells.Fórmula:C18H17NO2Forma y color:SolidPeso molecular:279.33
