MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 892 productos de "MAPK"
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TAK1/MAP4K2 inhibitor 1
CAS:TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.Fórmula:C29H31F3N6O2Pureza:98%Forma y color:SolidPeso molecular:552.59B-Raf IN 8
CAS:<p>B-Raf IN 8: strong B-Raf inhibitor (70.65 nM IC50); combats liver, colon, breast & prostate cancer with IC50s from 9.78 to 29.85 μM.</p>Fórmula:C18H17N3O2Forma y color:SolidPeso molecular:307.35NSC-70220
CAS:SOS1-IN-1 is an inhibitor of SOS1.Fórmula:C22H15NO2Pureza:98%Forma y color:SolidPeso molecular:325.36J30-8
CAS:J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Fórmula:C17H9ClFN3O2SPureza:99.90%Forma y color:SolidPeso molecular:373.79SB-747651A
CAS:SB-747651A: ATP-competitive MSK1 inhibitor (IC50=11nM), affects N-terminal domain, also hinders MSK2, PKA, PKB, RSK, p70S6K.Fórmula:C16H22N8OPureza:98%Forma y color:SolidPeso molecular:342.4Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Fórmula:C18H18N2O4Forma y color:SolidPeso molecular:326.35GNE-1858
CAS:GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).Fórmula:C21H26F2N8Pureza:99.36%Forma y color:SolidPeso molecular:428.48SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Fórmula:C28H26N8OPureza:99.38% - 99.71%Forma y color:SolidPeso molecular:490.56HPK1-IN-24
CAS:<p>HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].</p>Fórmula:C19H14FN5Forma y color:SolidPeso molecular:331.35Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Fórmula:C19H19ClF2N4O3SForma y color:SolidPeso molecular:456.89Ras modulator-1
CAS:Ras modulator-1 is a modulator of Ras.Fórmula:C29H21N5O4SForma y color:SolidPeso molecular:535.57MEK inhibitor
CAS:MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.Fórmula:C26H26N4O2Pureza:97.48%Forma y color:SolidPeso molecular:426.51Quazinone
CAS:Quazinone: PDE3 inhibitor, enhances heart muscle contractility, lowers blood pressure, and inhibits DNA synthesis in muscle cells. IC50 = 4.2 μM.Fórmula:C11H10ClN3OForma y color:SolidPeso molecular:235.67KRAS G12C inhibitor 22
CAS:KRAS G12C inhibitor 22 is a KRAS G12C inhibitor.Fórmula:C32H41N7O2Forma y color:SolidPeso molecular:555.71Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Fórmula:C26H28BrF3N4O2Pureza:98%Forma y color:SolidPeso molecular:565.43BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Fórmula:C19H13F4IN4O4SForma y color:SolidPeso molecular:596.29KRAS G12C inhibitor 31
CAS:KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.Fórmula:C25H22ClFN6O3Forma y color:SolidPeso molecular:508.93KRAS G12C inhibitor 48
KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.Fórmula:C36H39ClN8O2Forma y color:SolidPeso molecular:651.2RAS inhibitor Abd-7
CAS:Abd-7: potent RAS inhibitor (Kd=51 nM) that blocks RAS-effector PPI, disrupting KRAS, NRAS Q61H, HRAS G12V signaling.Fórmula:C23H25N3O3Forma y color:SolidPeso molecular:391.46PF-04880594
CAS:PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].Fórmula:C19H16F2N8Forma y color:SolidPeso molecular:394.38
