MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 886 productos de "MAPK"
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Xl-281
CAS:<p>XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.</p>Fórmula:C24H19ClN4O4Pureza:95.77% - 98.83%Forma y color:SolidPeso molecular:462.89K-Ras G12C-IN-4
CAS:<p>K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。</p>Fórmula:C31H33ClN4O4Pureza:99.00%Forma y color:SolidPeso molecular:561.07ACBI3
CAS:<p>ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.</p>Fórmula:C50H62N14O6S2Pureza:99.24%Forma y color:SolidPeso molecular:1019.25ERK5-IN-6
CAS:<p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>Fórmula:C23H21N3Pureza:98.59%Forma y color:SoildPeso molecular:339.43ARS-1630
CAS:<p>ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.</p>Fórmula:C21H17ClF2N4O2Pureza:97.78%Forma y color:SolidPeso molecular:430.84MK2-IN-3 hydrate
CAS:<p>MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)</p>Fórmula:C21H18N4O2Pureza:99.58%Forma y color:SolidPeso molecular:358.39INH154
CAS:<p>INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.</p>Fórmula:C22H24N4OSPureza:99.95%Forma y color:SolidPeso molecular:392.52RMC-6236
CAS:<p>RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.</p>Fórmula:C44H58N8O5SPureza:98.24% - 99.92%Forma y color:SolidPeso molecular:811.05Dilmapimod
CAS:<p>Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.</p>Fórmula:C23H19F3N4O3Pureza:97.53%Forma y color:SolidPeso molecular:456.42Pepinh-TRIF TFA
<p>Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction</p>Fórmula:C180H279F3N58O40S2Pureza:98%Forma y color:SolidPeso molecular:4014.09741ERK5-IN-5
CAS:<p>ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.</p>Fórmula:C19H16ClN3OPureza:99.77%Forma y color:SoildPeso molecular:337.8(R)-Ketorolac
CAS:<p>(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity.</p>Fórmula:C15H13NO3Pureza:99.55%Forma y color:SolidPeso molecular:255.27ETC-206
CAS:<p>ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).</p>Fórmula:C25H20N4O2Pureza:99.72% - 99.79%Forma y color:SolidPeso molecular:408.45SU3327
CAS:<p>SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).</p>Fórmula:C5H3N5O2S3Pureza:98.39%Forma y color:SolidPeso molecular:261.3MRTX-1257
CAS:<p>MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.</p>Fórmula:C33H39N7O2Pureza:97.3% - 99.07%Forma y color:SolidPeso molecular:565.71BI-3406
CAS:<p>BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.</p>Fórmula:C23H25F3N4O3Pureza:99.2% - 99.66%Forma y color:SolidPeso molecular:462.46Divarasib
CAS:<p>Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.</p>Fórmula:C29H32ClF4N7O2Pureza:99.237% - 99.83%Forma y color:SolidPeso molecular:622.06PF-3644022
CAS:<p>PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.</p>Fórmula:C21H18N4OSPureza:98.13%Forma y color:SolidPeso molecular:374.46Regorafénib N-oxyde (M2)
CAS:<p>Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.</p>Fórmula:C21H15ClF4N4O4Pureza:98.03% - 98.26%Forma y color:SolidPeso molecular:498.81Azelnidipine
CAS:<p>Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.</p>Fórmula:C33H34N4O6Pureza:99.78%Forma y color:Light Yellowish PowderPeso molecular:582.65AX-15836
CAS:<p>AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).</p>Fórmula:C32H40N8O5SPureza:98.96%Forma y color:SolidPeso molecular:648.78B-Raf IN 2
CAS:<p>B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.</p>Fórmula:C20H17F2N5O4SPureza:98.86%Forma y color:SolidPeso molecular:461.44JNK-IN-13
CAS:<p>JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.</p>Fórmula:C13H7ClN4SPureza:98.74%Forma y color:SolidPeso molecular:286.74Cephradine
CAS:<p>Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.</p>Fórmula:C16H19N3O4SPureza:99.63%Forma y color:White Crystalline Powder; Polymorphic SolidPeso molecular:349.40HI-TOPK-032
CAS:<p>HI-TOPK-032 is an effective and specific inhibitor of TOPK.</p>Fórmula:C20H11N5OSPureza:98.52%Forma y color:SolidPeso molecular:369.4LUT014
CAS:<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Fórmula:C27H19F3N8OPureza:99.03%Forma y color:SolidPeso molecular:528.49CC-90003
CAS:<p>CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.</p>Fórmula:C22H21F3N6O2Pureza:99.42%Forma y color:SolidPeso molecular:458.44Tanzisertib
CAS:<p>Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.</p>Fórmula:C21H23F3N6O2Pureza:98.66% - 99.28%Forma y color:SolidPeso molecular:448.44MAP4K4-IN-3
CAS:<p>MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.</p>Fórmula:C15H12ClN5Pureza:98.07%Forma y color:SolidPeso molecular:297.74Methylthiouracil
CAS:<p>Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.</p>Fórmula:C5H6N2OSPureza:99.89% - >99.99%Forma y color:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Peso molecular:142.18MRTX0902
CAS:<p>MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.</p>Fórmula:C22H24N6OPureza:99.69%Forma y color:SolidPeso molecular:388.47KRAS G12C inhibitor 19
CAS:<p>KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.</p>Fórmula:C25H19ClF2N4O3SPureza:97.46%Forma y color:SolidPeso molecular:528.96GW806742X
CAS:<p>GW806742X inhibits MLKL with Kd 9.3 μM, preventing necroptosis; also targets VEGFR2.</p>Fórmula:C25H22F3N7O4SPureza:98.3%Forma y color:SolidPeso molecular:573.55KRAS inhibitor-38
CAS:<p>KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.</p>Fórmula:C53H68ClF2N9O8SForma y color:SolidPeso molecular:1064.68NecroX-2
CAS:<p>NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.</p>Fórmula:C25H32N4O4S2Pureza:97.12%Forma y color:SolidPeso molecular:516.68JNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Fórmula:C32H30FN7O3Forma y color:SolidPeso molecular:579.62Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Forma y color:Odour SolidRac1 Inhibitor W56
CAS:<p>Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.</p>Fórmula:C74H117N19O23SPureza:98%Forma y color:SolidPeso molecular:1671.93LC 2 Epimer
CAS:<p>Negative control for LC 2.</p>Fórmula:C59H71ClFN11O7SForma y color:SolidPeso molecular:1132.8KRAS G12C inhibitor 60
<p>KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and</p>Fórmula:C31H30F5N7O2Pureza:98%Forma y color:SolidPeso molecular:627.61KRAS G12C inhibitor 18
CAS:<p>KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.</p>Fórmula:C25H20ClFN4O3SForma y color:SolidPeso molecular:510.97GNE-9815
CAS:<p>GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selective</p>Fórmula:C26H22FN5O2Pureza:99.08% - 99.1%Forma y color:SolidPeso molecular:455.48HPK1-IN-8
CAS:<p>HPK1-IN-8 is an allosteric, inactive, conformation-selective triazolopyrimidine ketone HPK1 inhibitor.</p>Fórmula:C19H17FN6O2SPureza:99.68%Forma y color:SolidPeso molecular:412.44KG5
CAS:<p>KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).</p>Fórmula:C20H16F3N7OSPureza:98.32%Forma y color:SolidPeso molecular:459.45KRAS G12C inhibitor 69
<p>KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.</p>Fórmula:C29H29ClF3N5O3Forma y color:SolidPeso molecular:588.02MC 976
CAS:<p>MC 976 is a derivative of Vitamin D3.</p>Fórmula:C27H42O3Pureza:98%Forma y color:SolidPeso molecular:414.63SS47
CAS:<p>SS47 is a PROTAC that degrades immunosuppressive HPK1 via proteasome; boosts BCMA CAR-T cell cancer therapy.</p>Fórmula:C49H56N6O12SForma y color:SolidPeso molecular:953.07MEK/RAF-IN-1
<p>MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.</p>Fórmula:C28H29F3N6O5SForma y color:SolidPeso molecular:618.63DS03090629
<p>DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.</p>Fórmula:C25H26ClN5O2Forma y color:SolidPeso molecular:463.9612-Oxo phytodienoic acid
CAS:<p>12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.</p>Fórmula:C18H28O3Pureza:98%Forma y color:SolidPeso molecular:292.41
