MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 891 productos para "MAPK". Se muestran los primeros 500.
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LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Fórmula:C27H19F3N8OPureza:99.03%Forma y color:SolidPeso molecular:528.49ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Fórmula:C21H17ClF2N4O2Pureza:97.78%Forma y color:SolidPeso molecular:430.84Ref: TM-T10376
1mg38,00€5mg86,00€1mL*10mM (DMSO)88,00€10mg112,00€25mg216,00€50mg310,00€100mg408,00€200mg580,00€Azelnidipine
CAS:Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.Fórmula:C33H34N4O6Pureza:99.78%Forma y color:White SolidPeso molecular:582.65Ref: TM-T0121
2mg34,00€5mg49,00€1mL*10mM (DMSO)59,00€10mg64,00€25mg103,00€50mg167,00€100mg260,00€200mg385,00€MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Fórmula:C21H18N4O2Pureza:99.58%Forma y color:SolidPeso molecular:358.39Ref: TM-T12058
1mg34,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg87,00€25mg172,00€50mg250,00€100mg350,00€200mg480,00€HI-TOPK-032
CAS:HI-TOPK-032 is an effective and specific inhibitor of TOPK.Fórmula:C20H11N5OSPureza:98.52%Forma y color:SolidPeso molecular:369.4CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Fórmula:C22H21F3N6O2Pureza:99.42%Forma y color:SolidPeso molecular:458.44BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Fórmula:C23H25F3N4O3Pureza:99.2% - 99.66%Forma y color:SolidPeso molecular:462.46Ref: TM-T12979
1mg70,00€5mg152,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg439,00€50mg628,00€100mg872,00€500mg1.738,00€(R)-Ketorolac
CAS:(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity.Fórmula:C15H13NO3Pureza:99.55%Forma y color:White SolidPeso molecular:255.27Ref: TM-T12624
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg222,00€50mg313,00€100mg437,00€Cephradine
CAS:Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.Fórmula:C16H19N3O4SPureza:99.63%Forma y color:White Crystalline Powder; Polymorphic SolidPeso molecular:349.40JNK-IN-13
CAS:JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.Fórmula:C13H7ClN4SPureza:98.74%Forma y color:SolidPeso molecular:286.74BAS 00489700
CAS:BAS 00489700 is a N-UTR interaction inhibitor. BAS 00489700 inhibits virus replication in cell culture.Fórmula:C19H16N2O4Pureza:99.78%Forma y color:SolidPeso molecular:336.34Ref: TM-T67854
1mg85,00€5mg170,00€1mL*10mM (DMSO)170,00€10mg250,00€25mg371,00€50mg522,00€100mg712,00€200mg954,00€AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Fórmula:C32H40N8O5SPureza:98.96%Forma y color:SolidPeso molecular:648.78Ref: TM-T14360
1mg54,00€2mg77,00€5mg114,00€1mL*10mM (DMSO)164,00€10mg167,00€25mg281,00€50mg401,00€100mg567,00€500mg1.161,00€ACBI3
CAS:ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Fórmula:C50H62N14O6S2Pureza:99.24% - 99.41%Forma y color:White SolidPeso molecular:1019.25BAY 2965501
CAS:BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.Fórmula:C20H19FN4O3SPureza:99.89%Forma y color:SolidPeso molecular:414.45(R)-BI-2852
CAS:(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.Fórmula:C31H28N6O2Pureza:97.80%Forma y color:SoildPeso molecular:516.59K-Ras G12C-IN-4
CAS:K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Fórmula:C31H33ClN4O4Pureza:99.41%Forma y color:White SolidPeso molecular:561.07Ref: TM-T11738
1mg71,00€5mg161,00€1mL*10mM (DMSO)192,00€10mg236,00€25mg403,00€50mg532,00€100mg783,00€200mg1.054,00€MAP4K4-IN-3
CAS:MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.Fórmula:C15H12ClN5Pureza:98.07%Forma y color:White SolidPeso molecular:297.74Ref: TM-T11942
5mg44,00€1mL*10mM (DMSO)48,00€10mg74,00€25mg144,00€50mg222,00€100mg354,00€200mg523,00€500mg797,00€PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Fórmula:C18H16F3IN2O2Pureza:99.66%Forma y color:SolidPeso molecular:476.23Ref: TM-T21980
1mg60,00€5mg131,00€1mL*10mM (DMSO)152,00€10mg178,00€25mg314,00€50mg447,00€100mg622,00€500mg1.224,00€TINK-IN-1
CAS:TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.Fórmula:C24H24N4O3Pureza:99.8%Forma y color:SolidPeso molecular:416.47Ref: TM-T77660
1mg39,00€2mg50,00€5mg82,00€10mg120,00€25mg236,00€50mg353,00€100mg517,00€500mg1.099,00€ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Fórmula:C19H16ClN3OPureza:99.89%Forma y color:SolidPeso molecular:337.8Ref: TM-T77734
1mg81,00€2mg105,00€5mg170,00€10mg264,00€25mg532,00€50mg868,00€100mg1.378,00€500mg2.673,00€Ro-3201195
CAS:Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.Fórmula:C19H18FN3O4Pureza:99.84%Forma y color:SolidPeso molecular:371.36Ref: TM-T68134
1mg122,00€5mg289,00€1mL*10mM (DMSO)311,00€10mg432,00€25mg707,00€50mg973,00€100mg1.333,00€500mg2.665,00€Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Fórmula:C24H19ClN4O4Pureza:95.77% - 98.83%Forma y color:White SolidPeso molecular:462.89MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Fórmula:C22H24N6OPureza:99.69%Forma y color:SolidPeso molecular:388.47ERK5-IN-6
CAS:ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Fórmula:C23H21N3Pureza:99.87%Forma y color:SolidPeso molecular:339.43B-Raf IN 2
CAS:B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Fórmula:C20H17F2N5O4SPureza:98.86%Forma y color:White SolidPeso molecular:461.44SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Fórmula:C5H3N5O2S3Pureza:98.39%Forma y color:SolidPeso molecular:261.3Divarasib
CAS:Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.Fórmula:C29H32ClF4N7O2Pureza:99.23% - 99.83%Forma y color:White SolidPeso molecular:622.06Ref: TM-T9972
1mg220,00€5mg522,00€1mL*10mM (DMSO)707,00€10mg737,00€25mg1.161,00€50mg1.603,00€100mg2.133,00€ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).Fórmula:C25H20N4O2Pureza:99.72% - 99.79%Forma y color:SolidPeso molecular:408.45Ref: TM-T15250
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg92,00€25mg140,00€50mg215,00€100mg318,00€500mg692,00€PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Fórmula:C21H18N4OSPureza:98.13%Forma y color:SolidPeso molecular:374.46Ref: TM-T16501
1mg34,00€5mg105,00€1mL*10mM (DMSO)177,00€10mg192,00€25mg394,00€50mg587,00€100mg788,00€500mg1.575,00€INH154
CAS:INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.Fórmula:C22H24N4OSPureza:99.95%Forma y color:SolidPeso molecular:392.52Ref: TM-T11657
2mg34,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg82,00€25mg136,00€50mg203,00€100mg299,00€200mg416,00€KRAS G12C inhibitor 19
CAS:KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.Fórmula:C25H19ClF2N4O3SPureza:97.46%Forma y color:SolidPeso molecular:528.96MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Fórmula:C33H39N7O2Pureza:96.76% - 97.3%Forma y color:Yellow SolidPeso molecular:565.71Ref: TM-T16143
1mg60,00€2mg85,00€5mg124,00€1mL*10mM (DMSO)166,00€10mg195,00€25mg351,00€50mg512,00€100mg743,00€200mg982,00€PROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Fórmula:C53H66FIN8O11S2Pureza:98%Forma y color:SolidPeso molecular:1201.17R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Fórmula:C101H157N27O29S3Pureza:98%Forma y color:SolidPeso molecular:2309.69BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Fórmula:C47H62N8O4SForma y color:SolidPeso molecular:835.11KRAS-IN-43
KRAS-IN-43 (Compound 9) is a broad-spectrum KRAS inhibitor with IC50 values of 0.15 μM for KRASG12V, 0.14 μM for KRASG12C, and 0.47 μM for wild-type KRAS. It disrupts the interaction between KRAS and cRAF and suppresses ERK phosphorylation. KRAS-IN-43 shows potential for research in KRAS mutation-associated cancers, including pancreatic, colorectal, and lung cancers.Forma y color:Odour SolidERK1/2 inhibitor 10
ERK1/2 inhibitor 10 (Compound 36c) is a potent inhibitor of ERK1 and ERK2, with IC50 values of 0.11 nM and 0.08 nM, respectively. It effectively hinders the phosphorylation of downstream substrates p90RSK and c-Myc. Additionally, ERK1/2 inhibitor 10 induces apoptosis and incomplete autophagy-related cell death. This compound demonstrates significant antitumor efficacy in models of triple-negative breast cancer and colorectal cancer harboring BRAF and RAS mutations.Fórmula:C23H20ClN5O2SPeso molecular:465.10262Setidegrasib
CAS:KRAS G12D inhibitor 17, a quinazoline-linked prolinamide, degrades mutant KRAS protein; a PROTAC.Fórmula:C60H65FN12O7SForma y color:White SolidPeso molecular:1117.3Cobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Fórmula:C21H21F3IN3O2Pureza:98%Forma y color:SolidPeso molecular:531.318Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFórmula:C18H13N3OSPureza:99.82%Forma y color:SolidPeso molecular:319.38Ref: TM-T67942
1mg54,00€5mg116,00€10mg172,00€1mL*10mM (DMSO)180,00€25mg278,00€50mg371,00€100mg510,00€200mg687,00€ASP6918
ASP6918 is a potent, orally active KRAS G12C inhibitor with an IC50 of 0.028 µM. It inhibits cell growth and demonstrates antitumor activity.Fórmula:C36H43N7O3Forma y color:SolidPeso molecular:621.34274TAT-PAK18 R192A
TAT-PAK18 R192A is an inactive Tat-Pak peptide. It does not influence Rac1 translocation triggered by any tested proteins.Fórmula:C143H247N55O37Peso molecular:3326.91369HPK1-IN-4
CAS:HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.Fórmula:C23H26N6O3Pureza:97.06%Forma y color:Yellow SolidPeso molecular:434.49Ref: TM-T40350
1mg123,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg447,00€25mg782,00€50mg1.071,00€100mg1.468,00€MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.Fórmula:C50H65F3IN7O6SPureza:98%Forma y color:SolidPeso molecular:1076.06(S,R,S)-AHPC-Me-C10-Br
CAS:(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate and ligand-linker for E3 ligase, MS432 for MEK1/2 inhibitors and a VHL E3 ligase linker.Fórmula:C34H51BrN4O4SPureza:98.89%Forma y color:SolidPeso molecular:691.76DS03090629
DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.Fórmula:C25H26ClN5O2Forma y color:SolidPeso molecular:463.96ADT-007
CAS:ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Fórmula:C26H24FNO5Pureza:97.75%Forma y color:SoildPeso molecular:449.47Ref: TM-T85316
1mg47,00€5mg96,00€1mL*10mM (DMSO)104,00€10mg124,00€25mg200,00€50mg353,00€100mg602,00€200mg982,00€KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Fórmula:C51H65F4N9O9S2Forma y color:SolidPeso molecular:1088.24Klotho-derived peptide 1 hydrochloride
Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.Forma y color:Odour SolidNK7-902 TFA
NK7-902 TFA is a CRBN molecular glue degrader of NEK7. It effectively degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. While NK7-902 TFA achieves deep and lasting NEK7 degradation, it temporarily blocks NLRP3 inflammasome activation in non-human primates when administered orally. Additionally, NK7-902 TFA demonstrates activity in mouse systems.Forma y color:Odour Solid
