MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 894 productos de "MAPK"
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PROTAC SOS1 degrader-2
CAS:PROTAC SOS1 degrader-2 reduces pERK & RAS-GTP, inhibiting tumor growth dose-dependently in vivo.Fórmula:C57H76ClFN10O4SForma y color:SolidPeso molecular:1051.79S6 Kinase Substrate Peptide 32
S6 Kinase Substrate Peptide 32 is a peptide that measures the activity of kinases that phosphorylate ribosomal protein S6. It can also be used as a substrate.Fórmula:C149H270N56O49Pureza:98%Forma y color:SolidPeso molecular:3630.1Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFórmula:C18H13N3OSPureza:99.82%Forma y color:SolidPeso molecular:319.38Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Fórmula:C19H30O3Forma y color:SolidPeso molecular:306.44MORINDONE
CAS:MORINDONE, an anthraquinone compound, exhibits significant binding affinity towards multiple targets including β-catenin, MDM2-p53, and KRAS. It displays notable cytotoxicity and selective activity against colorectal cancer cell lines, and effectively downregulates the expression of mutated TP53 and KRAS genes.Fórmula:C15H10O5Forma y color:SolidPeso molecular:270.24(+)-Oxanthromicin
CAS:(+)-Oxanthromicin, an enantiomer of the rare Streptomyces metabolite (−)-oxanthromicin, demonstrates inhibitory activity against K-Ras plasma membrane localization in MDCK cells, exhibiting an IC50 value of 62.5 μM.Fórmula:C36H30O12Forma y color:SolidPeso molecular:654.624Vacquinol-1
CAS:Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.Fórmula:C21H21ClN2OPureza:99.92%Forma y color:SolidPeso molecular:352.86PROTAC K-Ras Degrader-3
CAS:PROTAC K-Ras Degrader-3 is a PROTAC degrader targeting K-Ras, exhibiting a DC50 value of ≤ 1 nM against SW620 KRAS G12D and a GI50 value of ≤ 10 nM in inhibiting the growth of SW620 3D cells. It is used in cancer research.Fórmula:C57H67F2N9O6Forma y color:SolidPeso molecular:1012.20Cobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Fórmula:C21H21F3IN3O2Pureza:98%Forma y color:SolidPeso molecular:531.318Ras Inhibitory Peptide
CAS:Sos1, a GEF, activates ERK by converting Ras-GDP to Ras-GTP via Grb2. The PVPPR peptide inhibits this by blocking Sos1/Grb2 binding.Fórmula:C53H91N19O11Forma y color:SolidPeso molecular:1170.433IPS-06061
IPS-06061 is an orally active molecular glue that forms a ternary complex with CRBN and KRASG12D, capable of degrading KRAS G12D, with a DC50 of less than 500 nM.Fórmula:C22H26O3Forma y color:SolidPeso molecular:338.44KRAS G12D inhibitor 6
CAS:<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Fórmula:C32H37ClN8O2Forma y color:SolidPeso molecular:601.15ZZ151
ZZ151 is an effective and selective SOS1 PROTAC with in vivo anti-tumor efficacy against KRAS-mutant cancers. This compound induces rapid and specific degradation of SOS1 and exhibits strong anti-proliferative activity against a wide range of KRAS mutation-driven cancer cells. In murine xenograft models with KRASG12D and G12V mutations, ZZ151 demonstrates superior anticancer activity. It represents a promising lead compound for developing new chemotherapeutic agents targeting KRAS mutations.Fórmula:C54H68F3N9O6SForma y color:SolidPeso molecular:1028.23p38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Fórmula:C16H13FN2OS2Pureza:98.53%Forma y color:SolidPeso molecular:332.42Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Forma y color:Odour SolidSW083688
CAS:SW083688 is a potent and highly selective inhibitor of Thousand-And-One Kinase 2 (TAOK2) with an IC 50 value of 1.3 µmol/L.Fórmula:C23H25N3O5SForma y color:SolidPeso molecular:455.53PROTAC SOS1 degrader-4
PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].Fórmula:C53H65ClN8O7SPureza:98%Forma y color:SolidPeso molecular:993.65KRpep-2d TFA
KRpep-2d (TFA) is a potent inhibitor of K-Ras, effectively hindering the proliferation of K-Ras-driven cancer cells, thereby serving as a valuable asset forFórmula:C110H183F3N44O27S2Forma y color:SolidPeso molecular:2675.03MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Forma y color:Odour SolidPROTAC KRAS G12D degrader 2
PROTACKRAS G12D degrader 2 is a peptidomimetic molecule capable of inducing the degradation of SARS-CoV-2 3-chymotrypsin-like protease (3CLPro). Designed as a PROTAC molecule, it combines a dipeptidyl 3CLPro ligand based on GC-376 with a pomalidomide moiety, linked through a piperazine-piperidine linker.Fórmula:C46H57FN8O9Peso molecular:884.42325
