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MAPK

MAPK

Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.

Se han encontrado 892 productos de "MAPK"

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  • TINK-IN-1

    CAS:
    TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.
    Fórmula:C24H24N4O3
    Pureza:99.4%
    Forma y color:Soild
    Peso molecular:416.47

    Ref: TM-T77660

    1mg
    42,00€
    2mg
    52,00€
    5mg
    87,00€
    10mg
    127,00€
    25mg
    250,00€
    50mg
    373,00€
    100mg
    547,00€
    500mg
    1.159,00€
  • HI-TOPK-032

    CAS:
    <p>HI-TOPK-032 is an effective and specific inhibitor of TOPK.</p>
    Fórmula:C20H11N5OS
    Pureza:98.52%
    Forma y color:Solid
    Peso molecular:369.4

    Ref: TM-T15481

    2mg
    47,00€
    5mg
    69,00€
    10mg
    93,00€
    25mg
    188,00€
    50mg
    320,00€
    100mg
    550,00€
  • B-Raf IN 2

    CAS:
    B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.
    Fórmula:C20H17F2N5O4S
    Pureza:98.86%
    Forma y color:Solid
    Peso molecular:461.44

    Ref: TM-T40284

    1mg
    57,00€
    5mg
    125,00€
    10mg
    188,00€
    25mg
    335,00€
    50mg
    470,00€
    100mg
    662,00€
  • Pepinh-TRIF TFA


    Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction
    Fórmula:C180H279F3N58O40S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:4014.09741

    Ref: TM-T76089

    1mg
    126,00€
    5mg
    279,00€
    10mg
    464,00€
    25mg
    743,00€
    50mg
    1.008,00€
  • CC-90003

    CAS:
    CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.
    Fórmula:C22H21F3N6O2
    Pureza:99.42%
    Forma y color:Solid
    Peso molecular:458.44

    Ref: TM-T14894

    1mg
    48,00€
    5mg
    88,00€
    10mg
    137,00€
    25mg
    264,00€
    50mg
    376,00€
    100mg
    562,00€
    1mL*10mM (DMSO)
    89,00€
  • Xl-281

    CAS:
    XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.
    Fórmula:C24H19ClN4O4
    Pureza:95.77% - 98.83%
    Forma y color:Solid
    Peso molecular:462.89

    Ref: TM-T68170

    1mg
    279,00€
    5mg
    685,00€
    10mg
    938,00€
    25mg
    1.444,00€
    50mg
    1.882,00€
  • LUT014

    CAS:
    LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.
    Fórmula:C27H19F3N8O
    Pureza:99.03%
    Forma y color:Solid
    Peso molecular:528.49

    Ref: TM-T15794

    1mg
    43,00€
    5mg
    95,00€
    10mg
    117,00€
    25mg
    208,00€
    50mg
    293,00€
    100mg
    409,00€
    1mL*10mM (DMSO)
    99,00€
  • PF-3644022

    CAS:
    PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.
    Fórmula:C21H18N4OS
    Pureza:98.13%
    Forma y color:Solid
    Peso molecular:374.46

    Ref: TM-T16501

    1mg
    37,00€
    5mg
    111,00€
    10mg
    202,00€
    25mg
    416,00€
    50mg
    620,00€
    100mg
    832,00€
    500mg
    1.663,00€
    1mL*10mM (DMSO)
    187,00€
  • KRAS G12C inhibitor 19

    CAS:
    KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.
    Fórmula:C25H19ClF2N4O3S
    Pureza:97.46%
    Forma y color:Solid
    Peso molecular:528.96

    Ref: TM-T40286

    1mg
    90,00€
    5mg
    187,00€
    10mg
    280,00€
    25mg
    543,00€
    50mg
    777,00€
    100mg
    1.074,00€
  • BI-3406

    CAS:
    BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
    Fórmula:C23H25F3N4O3
    Pureza:99.2% - 99.66%
    Forma y color:Solid
    Peso molecular:462.46

    Ref: TM-T12979

    1mg
    73,00€
    5mg
    160,00€
    10mg
    250,00€
    25mg
    464,00€
    50mg
    663,00€
    100mg
    919,00€
    500mg
    1.833,00€
    1mL*10mM (DMSO)
    170,00€
  • ETC-206

    CAS:
    <p>ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).</p>
    Fórmula:C25H20N4O2
    Pureza:99.72% - 99.79%
    Forma y color:Solid
    Peso molecular:408.45

    Ref: TM-T15250

    2mg
    35,00€
    5mg
    52,00€
    10mg
    96,00€
    25mg
    148,00€
    50mg
    226,00€
    100mg
    335,00€
    500mg
    730,00€
  • HSND80


    HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.
    Forma y color:Odour Solid

    Ref: TM-T206458

    10mg
    A consultar
    50mg
    A consultar
  • Mitogen-activated protein kinase 1

    CAS:
    Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.
    Pureza:98%
    Forma y color:Solid

    Ref: TM-T80062

    5mg
    A consultar
    50mg
    A consultar
  • ADT-007

    CAS:
    <p>ADT-007 is a pan-RAS inhibitor with potent anticancer activity.</p>
    Fórmula:C26H24FNO5
    Pureza:97.75%
    Forma y color:Soild
    Peso molecular:449.47

    Ref: TM-T85316

    1mg
    49,00€
    5mg
    92,00€
    10mg
    131,00€
    25mg
    212,00€
    50mg
    373,00€
    100mg
    635,00€
    200mg
    1.035,00€
  • Antimicrobial agent-21

    CAS:
    Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of
    Fórmula:C18H13N3OS
    Pureza:99.82%
    Forma y color:Solid
    Peso molecular:319.38

    Ref: TM-T67942

    1mg
    57,00€
    5mg
    123,00€
    10mg
    180,00€
    25mg
    293,00€
    50mg
    393,00€
    100mg
    538,00€
    200mg
    725,00€
    1mL*10mM (DMSO)
    190,00€
  • RTIL 13

    CAS:
    RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).
    Fórmula:C30H55BrN2O3
    Forma y color:Solid
    Peso molecular:571.685

    Ref: TM-T38407

    5mg
    922,00€
  • KRAS G12C inhibitor 69


    KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.
    Fórmula:C29H29ClF3N5O3
    Forma y color:Solid
    Peso molecular:588.02

    Ref: TM-T204874

    10mg
    A consultar
    50mg
    A consultar
  • PROTAC MEK1 Degrader-1

    CAS:
    PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2
    Fórmula:C53H66FIN8O11S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:1201.17

    Ref: TM-T79144

    5mg
    A consultar
    50mg
    A consultar
  • BI1701963


    BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.
    Fórmula:C47H62N8O4S
    Forma y color:Solid
    Peso molecular:835.11

    Ref: TM-T201333

    10mg
    A consultar
    50mg
    A consultar
  • Kinase Inhibitor Library


    A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;
    Forma y color:Odour Solid

    Ref: TM-L1600

    1mg
    A consultar
    30μL*10mM (DMSO)
    A consultar
    50μL*10mM (DMSO)
    A consultar
    100μL*10mM (DMSO)
    A consultar
    250μL*10mM (DMSO)
    A consultar