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MAPK

MAPK

Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.

Se han encontrado 892 productos de "MAPK"

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  • HI-TOPK-032

    CAS:
    <p>HI-TOPK-032 is an effective and specific inhibitor of TOPK.</p>
    Fórmula:C20H11N5OS
    Pureza:98.52%
    Forma y color:Solid
    Peso molecular:369.4

    Ref: TM-T15481

    2mg
    47,00€
    5mg
    69,00€
    10mg
    93,00€
    25mg
    188,00€
    50mg
    320,00€
    100mg
    550,00€
  • AX-15836

    CAS:
    AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).
    Fórmula:C32H40N8O5S
    Pureza:98.96%
    Forma y color:Solid
    Peso molecular:648.78

    Ref: TM-T14360

    1mg
    57,00€
    2mg
    81,00€
    5mg
    120,00€
    10mg
    170,00€
    25mg
    298,00€
    50mg
    424,00€
    100mg
    597,00€
    500mg
    1.225,00€
    1mL*10mM (DMSO)
    167,00€
  • Pepinh-TRIF TFA


    Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction
    Fórmula:C180H279F3N58O40S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:4014.09741

    Ref: TM-T76089

    1mg
    126,00€
    5mg
    279,00€
    10mg
    464,00€
    25mg
    743,00€
    50mg
    1.008,00€
  • ERK5-IN-6

    CAS:
    <p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>
    Fórmula:C23H21N3
    Pureza:98.59%
    Forma y color:Soild
    Peso molecular:339.43

    Ref: TM-T77731

    1mg
    185,00€
    5mg
    459,00€
    10mg
    657,00€
    25mg
    1.026,00€
    50mg
    1.415,00€
    100mg
    1.872,00€
    500mg
    3.734,00€
  • CC-90003

    CAS:
    CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.
    Fórmula:C22H21F3N6O2
    Pureza:99.42%
    Forma y color:Solid
    Peso molecular:458.44

    Ref: TM-T14894

    1mg
    48,00€
    5mg
    88,00€
    10mg
    137,00€
    25mg
    264,00€
    50mg
    376,00€
    100mg
    562,00€
    1mL*10mM (DMSO)
    89,00€
  • JNK-IN-13

    CAS:
    <p>JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.</p>
    Fórmula:C13H7ClN4S
    Pureza:98.74%
    Forma y color:Solid
    Peso molecular:286.74

    Ref: TM-T77694

    10mg
    39,00€
    25mg
    57,00€
    50mg
    93,00€
  • ACBI3

    CAS:
    ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.
    Fórmula:C50H62N14O6S2
    Pureza:99.24%
    Forma y color:Solid
    Peso molecular:1019.25

    Ref: TM-T85547

    1mg
    280,00€
    5mg
    670,00€
    10mg
    1.005,00€
    25mg
    1.656,00€
    50mg
    2.314,00€
    1mL*10mM (DMSO)
    1.103,00€
  • MAP4K4-IN-3

    CAS:
    MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.
    Fórmula:C15H12ClN5
    Pureza:98.07%
    Forma y color:Solid
    Peso molecular:297.74

    Ref: TM-T11942

    5mg
    47,00€
    10mg
    79,00€
    25mg
    153,00€
    50mg
    235,00€
    100mg
    374,00€
    200mg
    552,00€
    500mg
    840,00€
    1mL*10mM (DMSO)
    50,00€
  • KRAS G12C inhibitor 19

    CAS:
    KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.
    Fórmula:C25H19ClF2N4O3S
    Pureza:97.46%
    Forma y color:Solid
    Peso molecular:528.96

    Ref: TM-T40286

    1mg
    90,00€
    5mg
    187,00€
    10mg
    280,00€
    25mg
    543,00€
    50mg
    777,00€
    100mg
    1.074,00€
  • MK2-IN-3 hydrate

    CAS:
    MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
    Fórmula:C21H18N4O2
    Pureza:99.58%
    Forma y color:Solid
    Peso molecular:358.39

    Ref: TM-T12058

    1mg
    35,00€
    5mg
    64,00€
    10mg
    93,00€
    25mg
    180,00€
    50mg
    264,00€
    100mg
    369,00€
    200mg
    507,00€
    1mL*10mM (DMSO)
    78,00€
  • HSND80


    HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.
    Forma y color:Odour Solid

    Ref: TM-T206458

    10mg
    A consultar
    50mg
    A consultar
  • Mitogen-activated protein kinase 1

    CAS:
    Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.
    Pureza:98%
    Forma y color:Solid

    Ref: TM-T80062

    5mg
    A consultar
    50mg
    A consultar
  • ADT-007

    CAS:
    <p>ADT-007 is a pan-RAS inhibitor with potent anticancer activity.</p>
    Fórmula:C26H24FNO5
    Pureza:97.75%
    Forma y color:Soild
    Peso molecular:449.47

    Ref: TM-T85316

    1mg
    49,00€
    5mg
    92,00€
    10mg
    131,00€
    25mg
    212,00€
    50mg
    373,00€
    100mg
    635,00€
    200mg
    1.035,00€
  • Antimicrobial agent-21

    CAS:
    Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of
    Fórmula:C18H13N3OS
    Pureza:99.82%
    Forma y color:Solid
    Peso molecular:319.38

    Ref: TM-T67942

    1mg
    57,00€
    5mg
    123,00€
    10mg
    180,00€
    25mg
    293,00€
    50mg
    393,00€
    100mg
    538,00€
    200mg
    725,00€
    1mL*10mM (DMSO)
    190,00€
  • RTIL 13

    CAS:
    RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).
    Fórmula:C30H55BrN2O3
    Forma y color:Solid
    Peso molecular:571.685

    Ref: TM-T38407

    5mg
    922,00€
  • KRAS G12C inhibitor 69


    KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.
    Fórmula:C29H29ClF3N5O3
    Forma y color:Solid
    Peso molecular:588.02

    Ref: TM-T204874

    10mg
    A consultar
    50mg
    A consultar
  • PROTAC MEK1 Degrader-1

    CAS:
    PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2
    Fórmula:C53H66FIN8O11S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:1201.17

    Ref: TM-T79144

    5mg
    A consultar
    50mg
    A consultar
  • BI1701963


    BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.
    Fórmula:C47H62N8O4S
    Forma y color:Solid
    Peso molecular:835.11

    Ref: TM-T201333

    10mg
    A consultar
    50mg
    A consultar
  • Kinase Inhibitor Library


    A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;
    Forma y color:Odour Solid

    Ref: TM-L1600

    1mg
    A consultar
    30μL*10mM (DMSO)
    A consultar
    50μL*10mM (DMSO)
    A consultar
    100μL*10mM (DMSO)
    A consultar
    250μL*10mM (DMSO)
    A consultar
  • R18

    CAS:
    14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.
    Fórmula:C101H157N27O29S3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:2309.69

    Ref: TM-TP2127

    1mg
    1.549,00€