MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 926 productos para "MAPK".
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ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).Fórmula:C25H20N4O2Pureza:99.72% - 99.79%Forma y color:SolidPeso molecular:408.4519ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Fórmula:C21H17ClF2N4O2Pureza:97.78%Forma y color:SolidPeso molecular:430.84MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Fórmula:C22H24N6OPureza:99.69%Forma y color:SolidPeso molecular:388.4656BAS 00489700
CAS:BAS 00489700 is a N-UTR interaction inhibitor. BAS 00489700 inhibits virus replication in cell culture.Fórmula:C19H16N2O4Pureza:99.78%Forma y color:SolidPeso molecular:336.3413ERK5-IN-6
CAS:ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Fórmula:C23H21N3Pureza:99.87%Forma y color:SolidPeso molecular:339.43Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Fórmula:C24H19ClN4O4Pureza:95.77% - 99.12%Forma y color:White SolidPeso molecular:462.89SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Fórmula:C5H3N5O2S3Pureza:98.39%Forma y color:SolidPeso molecular:261.3ACBI3
CAS:ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Fórmula:C50H62N14O6S2Pureza:99.24% - 99.41%Forma y color:White SolidPeso molecular:1019.25CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Fórmula:C22H21F3N6O2Pureza:99.42%Forma y color:SolidPeso molecular:458.4363INH154
CAS:INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.Fórmula:C22H24N4OSPureza:99.95%Forma y color:SolidPeso molecular:392.517MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Fórmula:C21H18N4O2Pureza:99.58%Forma y color:SolidPeso molecular:358.3932LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Fórmula:C27H19F3N8OPureza:99.03%Forma y color:Yellow SolidPeso molecular:528.488ERK1/2 inhibitor 10
ERK1/2 inhibitor 10 (Compound 36c) is a potent inhibitor of ERK1 and ERK2, with IC50 values of 0.11 nM and 0.08 nM, respectively. It effectively hinders the phosphorylation of downstream substrates p90RSK and c-Myc. Additionally, ERK1/2 inhibitor 10 induces apoptosis and incomplete autophagy-related cell death. This compound demonstrates significant antitumor efficacy in models of triple-negative breast cancer and colorectal cancer harboring BRAF and RAS mutations.Fórmula:C23H20ClN5O2SPeso molecular:465.10262HPK1-IN-4
CAS:HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.Fórmula:C23H26N6O3Pureza:97.06%Forma y color:Yellow SolidPeso molecular:434.4909BChE/p38-α MAPK-IN-2
BChE/p38-α MAPK-IN-2 is a dual inhibitor of BChE and p38-α MAPK. It has an IC50 of 5.1 nM for hBChE and exhibits a 1000-fold selectivity over hAChE. Its IC50 for p38α MAPK is 8.12 μM. BChE/p38-α MAPK-IN-2 demonstrates neuroprotective properties, making it useful for research on neurological disorders such as Alzheimer's disease.ASP6918
ASP6918 is a potent, orally active KRAS G12C inhibitor with an IC50 of 0.028 µM. It inhibits cell growth and demonstrates antitumor activity.Fórmula:C36H43N7O3Forma y color:SolidPeso molecular:621.34274MAPK Inhibitor Library
A unique collection of xnum cancer cell differentiation inducing compounds for high throughput and high content screening;Forma y color:Odour SolidRAS GTPase inhibitor 1
CAS:RAS GTPase inhibitor 1 Free Base is a highly potent RAS GTPase inhibitor with antitumor activity.Fórmula:C25H27ClFN5Forma y color:White SolidPeso molecular:451.97Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFórmula:C18H13N3OSPureza:99.82%Forma y color:SolidPeso molecular:319.38Z16078526
CAS:Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.Fórmula:C18H17N3O4SPureza:99.18%Forma y color:SolidPeso molecular:371.41
