MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 892 productos de "MAPK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
HI-TOPK-032
CAS:<p>HI-TOPK-032 is an effective and specific inhibitor of TOPK.</p>Fórmula:C20H11N5OSPureza:98.52%Forma y color:SolidPeso molecular:369.4AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Fórmula:C32H40N8O5SPureza:98.96%Forma y color:SolidPeso molecular:648.78Ref: TM-T14360
1mg57,00€2mg81,00€5mg120,00€10mg170,00€25mg298,00€50mg424,00€100mg597,00€500mg1.225,00€1mL*10mM (DMSO)167,00€Pepinh-TRIF TFA
Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interactionFórmula:C180H279F3N58O40S2Pureza:98%Forma y color:SolidPeso molecular:4014.09741ERK5-IN-6
CAS:<p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>Fórmula:C23H21N3Pureza:98.59%Forma y color:SoildPeso molecular:339.43CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Fórmula:C22H21F3N6O2Pureza:99.42%Forma y color:SolidPeso molecular:458.44JNK-IN-13
CAS:<p>JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.</p>Fórmula:C13H7ClN4SPureza:98.74%Forma y color:SolidPeso molecular:286.74ACBI3
CAS:ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Fórmula:C50H62N14O6S2Pureza:99.24%Forma y color:SolidPeso molecular:1019.25MAP4K4-IN-3
CAS:MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.Fórmula:C15H12ClN5Pureza:98.07%Forma y color:SolidPeso molecular:297.74Ref: TM-T11942
5mg47,00€10mg79,00€25mg153,00€50mg235,00€100mg374,00€200mg552,00€500mg840,00€1mL*10mM (DMSO)50,00€KRAS G12C inhibitor 19
CAS:KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.Fórmula:C25H19ClF2N4O3SPureza:97.46%Forma y color:SolidPeso molecular:528.96MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Fórmula:C21H18N4O2Pureza:99.58%Forma y color:SolidPeso molecular:358.39Ref: TM-T12058
1mg35,00€5mg64,00€10mg93,00€25mg180,00€50mg264,00€100mg369,00€200mg507,00€1mL*10mM (DMSO)78,00€HSND80
HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.Forma y color:Odour SolidMitogen-activated protein kinase 1
CAS:Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Pureza:98%Forma y color:SolidADT-007
CAS:<p>ADT-007 is a pan-RAS inhibitor with potent anticancer activity.</p>Fórmula:C26H24FNO5Pureza:97.75%Forma y color:SoildPeso molecular:449.47Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFórmula:C18H13N3OSPureza:99.82%Forma y color:SolidPeso molecular:319.38Ref: TM-T67942
1mg57,00€5mg123,00€10mg180,00€25mg293,00€50mg393,00€100mg538,00€200mg725,00€1mL*10mM (DMSO)190,00€RTIL 13
CAS:RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).Fórmula:C30H55BrN2O3Forma y color:SolidPeso molecular:571.685KRAS G12C inhibitor 69
KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.Fórmula:C29H29ClF3N5O3Forma y color:SolidPeso molecular:588.02PROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Fórmula:C53H66FIN8O11S2Pureza:98%Forma y color:SolidPeso molecular:1201.17BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Fórmula:C47H62N8O4SForma y color:SolidPeso molecular:835.11Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Forma y color:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarR18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Fórmula:C101H157N27O29S3Pureza:98%Forma y color:SolidPeso molecular:2309.69
