MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 894 productos de "MAPK"
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DT-061
CAS:DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.Fórmula:C25H23F3N2O5SPureza:98%Forma y color:SolidPeso molecular:520.52KRAS G12C inhibitor 59
CAS:KRAS G12C Inhibitor 59 is a compound with anticancer properties.Fórmula:C32H39F6N7O5Pureza:98%Forma y color:SolidPeso molecular:715.69BI-0474
CAS:<p>BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells & lung cancer model, for cancer research.</p>Fórmula:C30H37N9O2SPureza:99.61%Forma y color:SolidPeso molecular:587.74Rac1-IN-3
CAS:Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].Fórmula:C21H23N7O2Pureza:98%Forma y color:SolidPeso molecular:405.45HPK1-IN-35
CAS:HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM.Fórmula:C30H32N8O3SForma y color:SolidPeso molecular:584.69AZ-TAK1
CAS:"AZ-Tak1 inhibits TAK1 kinase (IC50=0.009mM), reduces p38/ERK levels, and induces apoptosis in Mino, SP53, Jeko cells with increasing efficacy at 0.1-0.5mM."Fórmula:C25H28FN7O2Forma y color:SolidPeso molecular:477.53SB 203580 sulfone
CAS:<p>SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].</p>Fórmula:C21H16FN3O2SForma y color:SolidPeso molecular:393.43pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Fórmula:C33H32F3N5O2Pureza:98%Forma y color:SolidPeso molecular:587.63K-Ras G12C-IN-1
CAS:K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.Fórmula:C22H23Cl2N3O3Forma y color:SolidPeso molecular:448.34SKF-86002 dihydrochloride
CAS:<p>p38 MAP kinase inhibitor</p>Fórmula:C16H14Cl2FN3SPureza:98%Forma y color:SolidPeso molecular:370.27pan-KRAS-IN-4
CAS:Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Fórmula:C36H34F2N6O3Pureza:98%Forma y color:SolidPeso molecular:636.69KRAS G12C inhibitor 5
CAS:KRAS G12C inhibitor 5 is a KRas G12C inhibitor.Fórmula:C32H37N7O2Pureza:98%Forma y color:SolidPeso molecular:551.68KRAS G12C inhibitor 34
CAS:KRAS G12C inhibitor 34 is an inhibitor of KRAS G12C that can be used to study cancer research.Fórmula:C32H32ClN5O3Forma y color:SolidPeso molecular:570.08TNIK&MAP4K4-IN-1
CAS:TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and <10 nM, respectively, in humanFórmula:C25H23FN4O3Forma y color:SolidPeso molecular:446.47KRas G12C inhibitor 1
CAS:KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.Fórmula:C31H38N6O3Pureza:98%Forma y color:SolidPeso molecular:542.67(aS)-PH-797804
CAS:(aS)-PH-797804 is a selective inhibitor of p38 MAPK, demonstrating inhibitory concentration (IC50) values of 26 nM for p38α and 102 nM for p38β. This compound exhibits anti-inflammatory activity [1] [2].Fórmula:C22H19BrF2N2O3Forma y color:SolidPeso molecular:477.3Deltasonamide 1
CAS:Deltasonamide is a potent and selective inhibitor of PDE6δ‐KRas.Fórmula:C30H39ClN6O4S2Forma y color:SolidPeso molecular:647.25ERK1/2 inhibitor 8
CAS:ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).Fórmula:C23H20ClN7O2SForma y color:SolidPeso molecular:493.97PROTAC KRAS G12C degrader-3
CAS:PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].Fórmula:C63H75ClN14O6Pureza:98%Forma y color:SolidPeso molecular:1159.81HPK1-IN-37
CAS:HPK1-IN-37 (compound A85), with an IC50 value of 3.7 nM, is a potent inhibitor of HPK1.Fórmula:C27H35N7O4Forma y color:SolidPeso molecular:521.61
