MEK

Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.

Honokiol is the active principle of magnolia extract. It inhibits the activation of Akt and …

Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It …

Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its …

Bufarenogin is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad Peltophryne …

BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more …

Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent …

GW284543 is a selective inhibitor of MEK5 .

Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and …

BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or …

5Z-7-Oxozeaenol is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 …

TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and …

Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of …

Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage …

(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values …

MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.

Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration …

PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces …

RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 …

EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated …

Binimetinib (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in …

GW 284543 hydrochloride is a selective inhibitor of MEK5 .

PD0325901 is a specific and non-ATP-competitive MEK inhibitor (IC50: 0.33 nM).

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.

Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).

AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. …

BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: …

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate …

PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region …

SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to …

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and …

RO4987655 is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).

PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) …

BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values …

U0126-EtOH is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).

U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with …

CI-1040 (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).

Isorhamnetin is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in …

BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and …

PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2).

SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak …

Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the …

zapnometinib is a MEK inhibitor.

Pimasertib is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic …

1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic …

BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for …

Refametinib (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: …

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.

RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 …

Selumetinib (AZD6244) is an effective, specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50: 14/10 nM).

MEK Inhibitor TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with …

Hederacolchiside A1 shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of …

Trametinib DMSO solvate is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 …

Cobimetinib is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib …

Kaempferol 3-neohesperidoside is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle.

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with …

Trametinib is an ATP-noncompetitive inhibitor of MEK 1/2 (IC50s: 0.7/0.9 nM). It shows low inhibition …

APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as …

Trans-Zeatina is the member of the plant growth hormone family known as cytokinins, which regulate …

MEK inhibitor is a potent MEK inhibitor with antitumor potency.

Pavinetant is an antagonist of the neurokinin-3 receptor (NK3R).

MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.

Cobimetinib racemate (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as …

EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).