Ras
Las proteínas Ras son pequeñas GTPasas que actúan como interruptores moleculares en la vía de señalización MAPK, controlando el crecimiento, la diferenciación y la supervivencia celular. Ras activado inicia una cascada de señalización que incluye Raf, MEK y ERK, lo que lleva a diversas respuestas celulares. Las mutaciones en los genes Ras son comunes en el cáncer, lo que convierte a Ras en un enfoque importante de la investigación oncológica. En CymitQuimica, ofrecemos una gama de moduladores de Ras para apoyar su investigación en biología del cáncer, transducción de señales y desarrollo terapéutico.
Se han encontrado 166 productos para "Ras".
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KRAS inhibitor-31
CAS:KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.Fórmula:C33H30F3N5O4Forma y color:SolidPeso molecular:617.62ZCL279
CAS:ZCL279 is a small molecule modulator (SMM) that inhibits the interaction between CDC42 and intersectin (ITSN). At lower concentrations (<10 μM), ZCL279 activates Cdc42, a cytoplasmic small GTPase in the Ras superfamily, while at higher concentrations (<10 μM) it significantly inhibits it.Fórmula:C24H18N2O7S2Forma y color:SolidPeso molecular:510.539AH001
CAS:AH001 is an orally active compound that binds to a concealed pocket near GDP within RhoA, exhibiting a binding affinity of 73.16 nM. By interacting with GDP, AH001 stabilizes the interaction between RhoA and its endogenous inhibitor, RhoGDIα. This compound reduces nuclear translocation of downstream MRTFA and downregulates fibrosis/hypertrophy-related proteins. AH001 alleviates myocardial remodeling in various heart failure animal models and 3D cardiac tissue models. Its cardioprotective effects are mediated through the RhoA-RhoGDIα axis, effectively inhibiting downstream RhoA activation signals.Fórmula:C10H14O2Peso molecular:166.22BMS-214662
CAS:BMS-214662 is a selective farnesyl transferase inhibitor with anti-tumor activity, used in research on pancreatic cancer, head and neck cancer, and lung cancer.Fórmula:C25H23N5O2S2Pureza:99.58% - 99.58%Forma y color:Yellow ViscousPeso molecular:489.61KRas G12C inhibitor 2
CAS:KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.Fórmula:C32H37N7O3Pureza:98%Forma y color:SolidPeso molecular:567.68KRAS inhibitor-41
CAS:KRAS inhibitor-41 is a KRAS inhibitor with an IC50 value of less than 0.01 μM for both KRAS G12D and KRAS G12V mutations. It effectively inhibits RAS mutant cell lines GP2D (KRAS-G12D) and SW620 (KRAS-G12V). KRAS inhibitor-41 is applicable for cancer research.Fórmula:C30H37FN10OSForma y color:SolidPeso molecular:604.745
