ERK
ERK es una proteína clave en la vía de señalización MAPK (Mitogen-Activated Protein Kinase), que está involucrada en la transmisión de señales desde los receptores de la superficie celular hasta el ADN en el núcleo celular. ERK juega un papel crucial en la regulación de varios procesos celulares, incluyendo la proliferación, diferenciación y supervivencia. La desregulación de la señalización ERK está asociada con el desarrollo de cáncer y otras enfermedades, lo que la convierte en un objetivo importante para la intervención terapéutica. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de ERK de alta calidad para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 193 productos de "ERK"
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VSLRGDTRG acetate
<p>VSLRGDTRG acetate is a synthetic peptide of the RGD motif from cadherin17 (CDH17), capable of binding to α2β1 integrin and activating its signaling pathways. It facilitates the high-affinity conformational change of β1 integrin via the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby promoting tumor proliferation and metastasis. VSLRGDTRG acetate is applicable in research on cancers expressing CDH17, such as colon and pancreatic cancers.</p>Forma y color:Odour Solid4-P-PDOT
CAS:<p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>Fórmula:C19H21NOPureza:99.91%Forma y color:SolidPeso molecular:279.38ERK1/2 inhibitor 3
CAS:<p>ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.</p>Fórmula:C28H31ClFN5O6SForma y color:SolidPeso molecular:620.09Anti-inflammatory agent 35
CAS:<p>Anti-inflammatory agent 35 is a potent anti-inflammatory agent.</p>Fórmula:C27H29NO8Pureza:99.98%Forma y color:SoildPeso molecular:495.52ROCK-IN-5
CAS:<p>ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.</p>Fórmula:C16H11ClFN3OSPureza:99.72% - 99.83%Forma y color:SolidPeso molecular:347.79BTX6654
<p>BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.</p>Fórmula:C50H57F4N9O5Forma y color:SolidPeso molecular:940.044′-Demethylnobiletin
CAS:<p>4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and</p>Fórmula:C20H20O8Forma y color:SolidPeso molecular:388.37GSK143
CAS:<p>GSK143: Oral SYK inhibitor, pIC50=7.5, curbs pErk, anti-inflammatory, hinders immune cells in mice.</p>Fórmula:C17H22N6O2Forma y color:SolidPeso molecular:342.403Edaxeterkib
CAS:<p>Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.</p>Fórmula:C26H27N7O2Forma y color:SolidPeso molecular:469.549Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Forma y color:Odour SolidPPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Fórmula:C54H69N11O6SPureza:98%Forma y color:SolidPeso molecular:1000.26PD 198306
CAS:<p>PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.</p>Fórmula:C18H16F3IN2O2Pureza:99.66%Forma y color:SolidPeso molecular:476.23VSLRGDTRG
CAS:<p>VSLRGDTRG is a synthetic peptide derived from the RGD motif in cadherin17 (CDH17) that binds to the α2β1 integrin, activating its signaling pathways. By promoting high-affinity conformational changes in β1 integrins through the RGD motif, VSLRGDTRG enhances cell adhesion and the phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. This peptide is useful for research on cancers expressing CDH17, such as colorectal and pancreatic cancer.</p>Fórmula:C38H69N15O14Forma y color:SolidPeso molecular:960.047Fulipiftide
CAS:<p>Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.</p>Fórmula:C144H227N41O47Forma y color:SolidPeso molecular:3284.59Rineterkib hydrochloride
CAS:<p>Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.</p>Fórmula:C26H28BrClF3N5O2Forma y color:SolidPeso molecular:614.89LC-SF-14
<p>LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.</p>Fórmula:C44H50Cl3N13O5SForma y color:SolidPeso molecular:977.28442Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Fórmula:C19H30O3Forma y color:SolidPeso molecular:306.44PROTAC MEK1 Degrader-1
CAS:<p>PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2</p>Fórmula:C53H66FIN8O11S2Pureza:98%Forma y color:SolidPeso molecular:1201.17MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Forma y color:Odour SolidSOS1-IN-18
<p>SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.</p>Fórmula:C26H29F3N4O2Forma y color:SolidPeso molecular:486.53
