ERK
ERK es una proteína clave en la vía de señalización MAPK (Mitogen-Activated Protein Kinase), que está involucrada en la transmisión de señales desde los receptores de la superficie celular hasta el ADN en el núcleo celular. ERK juega un papel crucial en la regulación de varios procesos celulares, incluyendo la proliferación, diferenciación y supervivencia. La desregulación de la señalización ERK está asociada con el desarrollo de cáncer y otras enfermedades, lo que la convierte en un objetivo importante para la intervención terapéutica. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de ERK de alta calidad para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 194 productos de "ERK"
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ERK5-IN-1
CAS:<p>ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).</p>Fórmula:C25H29N7O2Pureza:97.70%Forma y color:SolidPeso molecular:459.54Tauroursodeoxycholate
CAS:<p>Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.</p>Fórmula:C26H45NO6SPureza:98.77% - 99.93%Forma y color:White SolidPeso molecular:499.7Loureirin B
CAS:<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Fórmula:C18H20O5Pureza:99.33% - 99.86%Forma y color:SolidPeso molecular:316.35UNC569
CAS:<p>UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.</p>Fórmula:C22H29FN6Pureza:98.91% - 99.67%Forma y color:SolidPeso molecular:396.5DEL-22379
CAS:<p>DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.</p>Fórmula:C26H28N4O3Pureza:99.3% - 99.53%Forma y color:SolidPeso molecular:444.532,5-Dihydroxyacetophenone
CAS:<p>2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.</p>Fórmula:C8H8O3Pureza:99.75%Forma y color:Yellow PowderPeso molecular:152.15Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Fórmula:C15H12O5Pureza:98.76% - >99.99%Forma y color:SolidPeso molecular:272.25Pachymic acid
CAS:<p>Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.</p>Fórmula:C33H52O5Pureza:99.43% - >99.99%Forma y color:White PowderPeso molecular:528.76β-Neoendorphin acetate(77739-21-0 free base)
CAS:<p>beta-Neoendorphin acetate is an agonist of κ-opioid receptor</p>Fórmula:C56H81N13O14Pureza:99.91%Forma y color:SolidPeso molecular:1160.34GRK5-IN-2
CAS:<p>GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor.</p>Fórmula:C20H20N4O4Pureza:99.92%Forma y color:SolidPeso molecular:380.46-OAU
CAS:<p>6-OAU is a GPR84 agonist, activates it in HEK293 cells with a 105 nM EC50.</p>Fórmula:C12H21N3O2Pureza:98.14% - 99.01%Forma y color:SolidPeso molecular:239.31Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 99.55%Forma y color:SolidPeso molecular:383.82XMD17-109
CAS:<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Fórmula:C36H46N8O3Pureza:98.75% - 99.7%Forma y color:SolidPeso molecular:638.8A-674563 2HCl(552325-73-2(fb-2hcl))
<p>A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Fórmula:C22H24Cl2N4OPureza:94.66%Forma y color:SolidPeso molecular:431.36DCLK1-IN-1
CAS:<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>Fórmula:C26H28F3N7O2Pureza:98.55% - 99.28%Forma y color:SolidPeso molecular:527.54AG126
CAS:AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.Fórmula:C10H5N3O3Pureza:97.35%Forma y color:SolidPeso molecular:215.16Epieriocalyxin A
CAS:<p>Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.</p>Fórmula:C20H24O5Pureza:97.00%Forma y color:SolidPeso molecular:344.4DMU-212
CAS:<p>DMU-212, a Resveratrol derivative, has antimitotic, antiproliferative, antioxidant properties; induces apoptosis via ERK1/2.</p>Fórmula:C18H20O4Pureza:99.86%Forma y color:SolidPeso molecular:300.35SUN11602
CAS:<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Fórmula:C26H37N5O2Pureza:99.36%Forma y color:SolidPeso molecular:451.6RU-301
CAS:<p>RU-301 is a novel pan-tam inhibitor</p>Fórmula:C21H19F3N4O4SPureza:98.87%Forma y color:SolidPeso molecular:480.46ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Fórmula:C22H25ClFN7O2Pureza:99.55% - 99.76%Forma y color:SolidPeso molecular:473.93Methylnissolin
CAS:<p>Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.</p>Fórmula:C17H16O5Pureza:99.68% - 99.98%Forma y color:SolidPeso molecular:300.31EF24
CAS:<p>EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.</p>Fórmula:C19H15F2NOPureza:99.71%Forma y color:SolidPeso molecular:311.33Deltonin
CAS:<p>Deltonin inhibits ERK1/2 & AKT; toxic to HepG2 (IC50: 7.66μM), C26 (IC50: 1.22μM), MDA-MB-231 cells (IC50: 1.58μM).</p>Fórmula:C45H72O17Pureza:98.77% - 99.79%Forma y color:SolidPeso molecular:885.04trans-Zeatin
CAS:<p>trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient</p>Fórmula:C10H13N5OPureza:97.13% - 98.96%Forma y color:White To Light Yellow Crystal PowderPeso molecular:219.24Ravoxertinib
CAS:<p>Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).</p>Fórmula:C21H18ClFN6O2Pureza:98% - 99.87%Forma y color:SolidPeso molecular:440.86Bohemine
CAS:<p>Bohemine is a cyclin-dependent kinase inhibitor.</p>Fórmula:C18H24N6OPureza:99.09% - 99.53%Forma y color:SolidPeso molecular:340.42Prosaptide TX14(A) acetate
<p>Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.</p>Fórmula:C71H114N16O28Pureza:95.29%Forma y color:SolidPeso molecular:1639.76Tauroursodeoxycholate sodium
CAS:<p>Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.</p>Fórmula:C26H44NNaO6SPureza:97.90%Forma y color:SolidPeso molecular:521.69FR 180204
CAS:<p>FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.</p>Fórmula:C18H13N7Pureza:98% - 99.74%Forma y color:SolidPeso molecular:327.34MRTX1133
CAS:<p>View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.</p>Fórmula:C33H31F3N6O2Pureza:97.39% - 99.6%Forma y color:SolidPeso molecular:600.63KO-947
CAS:<p>KO-947 is a potent and specific inhibitor of ERK1/2 kinases.</p>Fórmula:C21H17N5OPureza:97.84%Forma y color:SolidPeso molecular:355.39LM22B-10
CAS:<p>LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.</p>Fórmula:C27H33ClN2O4Pureza:98.18%Forma y color:SolidPeso molecular:485.01AZD8330
CAS:<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Fórmula:C16H17FIN3O4Pureza:98.72%Forma y color:SolidPeso molecular:461.23Tizaterkib
CAS:<p>Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.</p>Fórmula:C24H24F2N8O2Pureza:99.6% - 99.63%Forma y color:SolidPeso molecular:494.5ERK-IN-4
CAS:<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Fórmula:C14H17ClN2O3SPureza:98.92% - 99.84%Forma y color:SolidPeso molecular:328.814Ulixertinib hydrochloride
CAS:<p>Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis</p>Fórmula:C21H23Cl3N4O2Pureza:99.85%Forma y color:SolidPeso molecular:469.79CAY10561
CAS:<p>CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.</p>Fórmula:C22H17Cl2FN4O2Forma y color:SolidPeso molecular:459.3GP17
CAS:<p>GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.</p>Fórmula:C26H21F3N4OForma y color:SolidPeso molecular:462.47UC-857993
CAS:<p>UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.</p>Fórmula:C25H22ClNO2Forma y color:SolidPeso molecular:403.9BNC-1
CAS:<p>BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.</p>Fórmula:C16H14N2O3Pureza:98%Forma y color:SolidPeso molecular:282.29mSIRK
CAS:<p>mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.</p>Fórmula:C93H150N20O25Pureza:99.26%Forma y color:SolidPeso molecular:1948.31Dihydrolipoic acid
CAS:<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Fórmula:C8H16O2S2Pureza:97.51%Forma y color:Yellow To Orange LiquidPeso molecular:208.34ERK5-IN-4
CAS:<p>ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.</p>Fórmula:C16H11Cl2FN4O2Forma y color:SolidPeso molecular:381.19PERK-IN-3
CAS:<p>PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).</p>Fórmula:C22H16F2N4O2Pureza:98%Forma y color:SolidPeso molecular:406.38ADTL-EI1712
CAS:<p>ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.</p>Fórmula:C22H18Cl2N4O2S2Forma y color:SolidPeso molecular:505.44ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Fórmula:C29H32ClN5O4Pureza:98.81%Forma y color:SolidPeso molecular:550.052,5-Dihydroxybiphenyl
CAS:<p>2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.</p>Fórmula:C12H10O2Pureza:99.66%Forma y color:White To Grey-Brownish PowderPeso molecular:186.21ERK5-IN-3
CAS:<p>ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).</p>Fórmula:C24H23Cl2FN4O2Forma y color:SolidPeso molecular:489.37GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFórmula:C18H24O4Pureza:98%Forma y color:SolidPeso molecular:304.38
