Transportador de membrana / canal de iones
Los inhibidores de transportadores de membrana y canales iónicos son compuestos que bloquean la función de proteínas responsables del transporte de iones, nutrientes y otras moléculas a través de las membranas celulares. Estos inhibidores son cruciales para estudiar la regulación de la homeostasis celular, la transducción de señales y la neurotransmisión. Los inhibidores de transportadores de membrana y canales iónicos también son importantes para desarrollar tratamientos para trastornos como la epilepsia, las enfermedades cardiovasculares y los síndromes metabólicos. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de transportadores de membrana y canales iónicos para apoyar su investigación en fisiología, neurociencia y farmacología.
Subcategorías de "Transportador de membrana / canal de iones"
- ABC(3 productos)
- ATPasa(93 productos)
- Receptor de adiponectina(5 productos)
- CFTR(64 productos)
- Receptor CGRP(51 productos)
- Canal de calcio(493 productos)
- Canal de cloruro(49 productos)
- Receptor GABA(336 productos)
- Transportador de monoamina(23 productos)
- Transportador de monocarboxilato(17 productos)
- NKCC(2 productos)
- NPC1L1(3 productos)
- Cotransportador de Na-K-Cl(8 productos)
- OAT(27 productos)
- OCT(7 productos)
- P-gp(53 productos)
- Canal de potasio(276 productos)
- Bomba de protones(39 productos)
- SGLT(30 productos)
- Canal de sodio(202 productos)
- Canal TRP / TRPV(92 productos)
Mostrar 13 subcategorías más
Se han encontrado 2270 productos de "Transportador de membrana / canal de iones"
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UCL 1684 dibromide
CAS:<p>apamin-sensitive Ca2+-activated K+ channel (KCa2.1) blocker</p>Fórmula:C34H30Br2N4Pureza:98%Forma y color:SolidPeso molecular:654.45Milbemycin A4
CAS:<p>Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. It acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.</p>Fórmula:C32H46O7Forma y color:SolidPeso molecular:542.713Anticonvulsant agent 9
<p>Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.</p>Fórmula:C22H24N4O2Forma y color:SolidPeso molecular:376.45Chlorotoxin
CAS:<p>Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.</p>Fórmula:C158H249N53O47S11Pureza:98%Forma y color:SolidPeso molecular:3995.71Homocarnosine TFA
<p>Homocarnosine TFA: brain-exclusive GABA-histidine dipeptide, neuronal, anticonvulsant, antioxidant, anti-inflammatory.</p>Fórmula:C12H17F3N4O5Forma y color:SolidPeso molecular:354.28Fumitremorgin C
CAS:<p>Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.</p>Fórmula:C22H25N3O3Pureza:98%Forma y color:SolidPeso molecular:379.45Anticonvulsant agent 8
<p>Anticonvulsant agent 8 (compound D4) is a chemical used in treating epilepsy by inhibiting GABAA currents. In mouse models, its ED50 values are 2.23 mg/kg for the maximal electroshock (MES) test and 24.60 mg/kg for the pentylenetetrazol (PTZ) test.</p>Fórmula:C15H11N5OForma y color:SolidPeso molecular:277.28(S)-JNJ-54166060
CAS:<p>(S)-JNJ-54166060, an enantiomer of JNJ-54166060, functions as a potent antagonist of P2X7 [1].</p>Fórmula:C20H15ClF4N4OForma y color:SolidPeso molecular:438.81Idrevloride
CAS:<p>Idrevloride (WO2016133967) inhibits ENaC, used in skin disorder research.</p>Fórmula:C30H49ClN8O7Forma y color:SolidPeso molecular:669.22Vesnarinone HCl
<p>Vesnarinone HCl is an oral PDE3 inhibitor improving heart contractility, affecting calcium and potassium flux. Used in heart failure research.</p>Fórmula:C22H26ClN3O4Pureza:99.17%Forma y color:SoildPeso molecular:431.91GaTx2
CAS:<p>High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.</p>Fórmula:C125H199N39O47S6Pureza:98%Forma y color:SolidPeso molecular:3192.54AZD-3161
CAS:<p>AZD-3161 is a sodium channel regulator for pain.</p>Fórmula:C23H21F3N4O4Forma y color:SolidPeso molecular:474.43Endosulfan I
CAS:<p>Endosulfan I is one of the two major stereoisomers of the broad-spectrum insecticide Endosulfan inhibi the GABA/benzodiazepine/picrotoxin complex</p>Fórmula:C9H6Cl6O3SPureza:99.86%Forma y color:SolidPeso molecular:406.93Vanzacaftor
CAS:<p>Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.</p>Fórmula:C32H39N7O4SPureza:99.14%Forma y color:SolidPeso molecular:617.76Linoleic Acid Amide
CAS:<p>Linoleic Acid Amide (Linoleamide) is derived from linoleic acid and regulates Ca2+ flux by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase.</p>Fórmula:C18H33NOPureza:98%Forma y color:SolidPeso molecular:279.46Iberiotoxin
CAS:<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Fórmula:C179H274N50O55S7Pureza:98%Forma y color:SolidPeso molecular:4230GX 201
CAS:<p>GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.</p>Fórmula:C25H27ClF4N2O4SPureza:99.81%Forma y color:SolidPeso molecular:563α5-GABAA receptor modulator 1
<p>α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.</p>Fórmula:C21H20FN3O4Forma y color:SolidPeso molecular:397.4TRPA1 Antagonist 3
CAS:<p>TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.</p>Fórmula:C11H8ClN3Forma y color:SolidPeso molecular:217.66Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Fórmula:C19H23F2N3O2Forma y color:SolidPeso molecular:363.4Agitoxin-2
CAS:<p>Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).</p>Fórmula:C169H278N54O48S8Pureza:98%Forma y color:SolidPeso molecular:4090.87Elgodipine
CAS:<p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>Fórmula:C29H33FN2O6Pureza:98.95% - 99.50%Forma y color:SolidPeso molecular:524.58BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Fórmula:C22H23F7N2O3Forma y color:SolidPeso molecular:496.418Lyso-Globotriaosylceramide (d18:1)
CAS:<p>Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.</p>Fórmula:C36H67NO17Forma y color:SolidPeso molecular:785.922Resolvin D2 methyl ester
CAS:<p>RvD2 is an anti-inflammatory lipid made from docosahexaenoic acid by 15- and 5-lipoxygenase. Its methyl ester may serve as a prodrug.</p>Fórmula:C23H34O5Forma y color:SolidPeso molecular:390.52Mesoridazine free base
CAS:<p>Mesoridazine (thioridazine EP impurity B) is a phenothiazine antipsychotic with effects similar to chlorpromazine.</p>Fórmula:C21H26N2OS2Forma y color:SolidPeso molecular:386.57Margatoxin
CAS:<p>KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.</p>Fórmula:C178H286N52O50S7Pureza:98%Forma y color:SolidPeso molecular:4178.96OD1
<p>Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.</p>Fórmula:C308H466N90O95S8Pureza:98%Forma y color:SolidPeso molecular:7206.1TRPV4 antagonist 4
CAS:<p>Potent TRPV4 blocker with 22.65 nM IC50; inhibits current and aids acute lung injury.</p>Fórmula:C28H32Cl2N6OForma y color:SolidPeso molecular:539.50Levamlodipine besylate Hemipentahydrate
CAS:<p>Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.</p>Fórmula:C20H25ClN2O5·C6H6O3SH2OForma y color:SolidPeso molecular:1224.18PptT-IN-4
<p>PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.</p>Fórmula:C17H23N3Pureza:98%Forma y color:SolidPeso molecular:269.38P-gp inhibitor 15
<p>P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123</p>Fórmula:C35H60N2O4Forma y color:SolidPeso molecular:572.86Dofetilide N-oxide
CAS:<p>Dofetilide N-oxide (UK-116856) is a metabolite of dofetilide. Dofetilide can block potassium channels and is a tertiary antiarrhythmic drug.</p>Fórmula:C19H27N3O6S2Pureza:98%Forma y color:SolidPeso molecular:457.56BuChE-IN-9
<p>BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM.</p>Fórmula:C28H34N4O2Forma y color:SolidPeso molecular:458.6Prilocaine acetate
<p>Prilocaine acetate, an amino amide compound, functions as a Na/K-ATPase inhibitor, exhibiting neurotoxic effects [1] [2].</p>Fórmula:C15H24N2O3Forma y color:SolidPeso molecular:280.36AQP4 (205-215)
CAS:<p>AQP4 (205-215) is a fragment of the water channel protein Aquaporin-4 (AQP4). This protein is an autoimmune antigen in optic neuromyelitis and, upon binding with CD40, is upregulated and presented in B cells. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).</p>Fórmula:C48H75N13O17SForma y color:SolidPeso molecular:1138.25α,β-Methylene-ATP dilithium
CAS:<p>α,β-Methylene ATP dilithium, a phosphonic analog of ATP, serves as a ligand for P2X3 and P2X7 receptors.</p>Fórmula:C11H16Li2N5O12P3Forma y color:SolidPeso molecular:517.07Lifastuzumab
CAS:<p>Sulfamethoxazole-NO (SMX-NO) is a SMX-NO derivative and is the primary immunogen for sulfonamide hypersensitivity reactions.</p>Pureza:97% (SDS-PAGE); 99.5% (SEC-HPLC) - 97% (SDS-PAGE); 99.5% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.5 kDa8-Bromo-ATP
CAS:<p>8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate) is a purinergic P2X receptor agonist and an ATP analogue.</p>Fórmula:C10H15BrN5O13P3Forma y color:SolidPeso molecular:586.077LY-466195
CAS:<p>LY-466195 is a competitive antagonist of GLUK5 receptor.</p>Fórmula:C16H24F2N2O4Forma y color:SolidPeso molecular:346.37Crofelemer
CAS:<p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>Forma y color:SolidWay 125971
CAS:<p>Way 125971 is a bioactive chemcial.</p>Fórmula:C22H28N4O5S2Forma y color:SolidPeso molecular:492.61Roquefortine C
CAS:<p>Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins</p>Fórmula:C22H23N5O2Pureza:98%Forma y color:SolidPeso molecular:389.45Analgesic/antidepressant agent-1
<p>Analgesic/antidepressant agent-1 (Compound k1) is an orally active N-acetylamino chloro ketone derivative capable of crossing the blood-brain barrier. It exhibits high affinity for NMDA receptors and demonstrates analgesic, anti-inflammatory, and antidepressant properties, with low psychotomimetic activity.</p>Fórmula:C22H25ClN2O2Forma y color:SolidPeso molecular:384.9GluN2B-NMDAR antagonist-1
<p>Orally active GluN2B-NMDAR antagonist with neuroprotective properties for ischemic injury research.</p>Fórmula:C26H23BrN2O2Forma y color:SolidPeso molecular:475.38(+)-Lycoctonine
CAS:<p>Compound TJS1874 is a useful organic compound for research related to life sciences. The catalog number is TJS1874 and the CAS number is 26000-17-9.</p>Fórmula:C25H41NO7Forma y color:SolidPeso molecular:467.6Phrixotoxin 3
CAS:<p>Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.</p>Fórmula:C176H269N51O48S6Pureza:98%Forma y color:SolidPeso molecular:4059.74Nav1.7-IN-8
CAS:<p>Nav1.7-IN-8 selectively inhibits NaV1.7 over hNaV1.1/1.5, affects CYP2C9/3A4 (IC50: 0.17/0.077 μM), and provides rodent pain relief.</p>Fórmula:C21H12ClF2N5O4S2Forma y color:SolidPeso molecular:535.93Apamin acetate
<p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>Pureza:96.97%Forma y color:SolidS-Sulfo-L-cysteine sodium salt
CAS:<p>S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.</p>Fórmula:C3H6NNaO5S2Pureza:99.88%Forma y color:SolidPeso molecular:223.2
