CFTR
El CFTR es una proteína de canal de cloruro que regula el transporte de iones cloruro y bicarbonato a través de las membranas de las células epiteliales, desempeñando un papel crucial en el mantenimiento del equilibrio de fluidos en los tejidos. Las mutaciones en el gen CFTR conducen a la fibrosis quística, un trastorno genético caracterizado por la producción de moco espeso que puede obstruir las vías respiratorias y provocar graves problemas respiratorios y digestivos. En CymitQuimica, ofrecemos una selección de moduladores de CFTR para apoyar su investigación en fibrosis quística, transporte de iones y trastornos genéticos.
Se han encontrado 66 productos para "CFTR".
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CFTR corrector 8
CAS:CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.Fórmula:C29H27F2NO7Pureza:99.57%Forma y color:White SolidPeso molecular:539.52Ref: TM-T63806
1mg34,00€5mg78,00€1mL*10mM (DMSO)90,00€10mg109,00€25mg212,00€50mg334,00€100mg548,00€200mg737,00€Chromanol 293B
CAS:Chromanol 293B, Cardiac IK and CFTR chloride current inhibitor (IC50=1-19 μM), weak KATP channel blocker, for arrhythmia research.Fórmula:C15H20N2O4SPureza:99.78%Forma y color:White SolidPeso molecular:324.4(R)-Elexacaftor
CAS:(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.Fórmula:C26H34F3N7O4SPureza:98.99%Forma y color:White SolidPeso molecular:597.65Ref: TM-T78240
1mg92,00€5mg230,00€1mL*10mM (DMSO)304,00€10mg371,00€25mg712,00€50mg1.009,00€100mg1.378,00€CRF1 receptor antagonist-1
CAS:CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].Fórmula:C27H28ClFN2O2SPureza:98%Forma y color:SolidPeso molecular:499.04CFTR corrector 6
CAS:CFTR corrector 6, a potent CFTR potentiator, aids cystic fibrosis research and related disorders.Fórmula:C22H13F4N9Forma y color:SolidPeso molecular:479.39CFTR corrector 12
CAS:CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.Fórmula:C19H21ClN4O2S2Pureza:99.47%Forma y color:SolidPeso molecular:436.98DNDS
CAS:DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).Fórmula:C14H8N2Na2O10S2Pureza:99.92%Forma y color:Yellow SolidPeso molecular:474.33BPO-27 racemate
CAS:BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.Fórmula:C26H18BrN3O6Pureza:97.67% - 98.86%Forma y color:SolidPeso molecular:548.34Ref: TM-T10591
1mg44,00€5mg111,00€1mL*10mM (DMSO)128,00€10mg166,00€25mg265,00€50mg388,00€100mg535,00€200mg718,00€(R)-Vanzacaftor
CAS:(R)-Vanzacaftor ((R)-VX-121) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator [1].Fórmula:C32H39N7O4SForma y color:SolidPeso molecular:617.76CFTR corrector 4
CAS:Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.Fórmula:C29H27F2NO7Pureza:99.32%Forma y color:White SolidPeso molecular:539.52Ref: TM-T10776
1mg46,00€5mg100,00€1mL*10mM (DMSO)119,00€10mg156,00€25mg304,00€50mg429,00€100mg610,00€CFTR corrector 18
CAS:CFTRcorrector 18 (Compound I-99) acts as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It enhances the processing and trafficking of CFTR, thereby increasing the amount of CFTR present on the cell surface. CFTRcorrector 18 holds potential for research in cystic fibrosis (CF).Fórmula:C38H40N6O5SForma y color:SolidPeso molecular:692.826Crinecerfont tosylate
CAS:Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).Fórmula:C34H36ClFN2O4S2Forma y color:SolidPeso molecular:655.242CFTR corrector 15
CAS:CFTR Corrector 15 (Compound 4172) serves as a corrector for cystic fibrosis transmembrane conductance regulator (CFTR). When used in combination with VX-809, it addresses the folding defects of F508del-CFTR. CFTR Corrector 15 is also applicable in the research of cystic fibrosis.Fórmula:C24H22ClN5O2SForma y color:SolidPeso molecular:479.98CFTR corrector 16
CAS:CFTRcorrector 16 (Compound 39) is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), utilized in the research of cystic fibrosis disease.Fórmula:C27H26ClN5O2SForma y color:SolidPeso molecular:520.05CFTR corrector 17
CAS:CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.Fórmula:C18H15FN2O2Forma y color:SolidPeso molecular:310.32ARN23765
CAS:ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).Fórmula:C30H22F5N3O6Forma y color:SolidPeso molecular:615.504
