Canal TRP / TRPV
Los canales TRP (Receptor Potencial Transitorio), incluida la subfamilia TRPV, son un grupo de canales iónicos involucrados en diversos procesos sensoriales, como la sensación de temperatura, la percepción del dolor y la osmorregulación. Los canales TRP están ampliamente expresados en diferentes tejidos y desempeñan un papel en las respuestas fisiológicas a estímulos ambientales. Los canales TRPV, en particular, están involucrados en la detección de cambios de temperatura y están implicados en condiciones como el dolor crónico, la inflamación y el cáncer. En CymitQuimica, ofrecemos una gama completa de moduladores de canales TRP/TRPV para apoyar su investigación en biología sensorial, manejo del dolor y transducción de señales.
Se han encontrado 92 productos de "Canal TRP / TRPV"
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(Z)-Capsaicin
CAS:<p>(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of</p>Fórmula:C18H27NO3Pureza:97.33% - 98.91%Forma y color:SolidPeso molecular:305.41Vocacapsaicin hydrochloride
CAS:<p>Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.</p>Fórmula:C26H42ClN3O4Pureza:99.66% - 99.80%Forma y color:SolidPeso molecular:496.08TRPV4 agonist-1 free base
CAS:<p>TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).</p>Fórmula:C25H22F2N4O2Pureza:99.79%Forma y color:SolidPeso molecular:448.46BI-749327
CAS:<p>BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).</p>Fórmula:C23H21F3N4O2Pureza:99.68%Forma y color:SolidPeso molecular:442.43IA-Alkyne
CAS:<p>IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.</p>Fórmula:C8H12INOPureza:99.76%Forma y color:SolidPeso molecular:265.09GFB-8438
CAS:<p>GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).</p>Fórmula:C16H14ClF3N4O2Pureza:99.58%Forma y color:SolidPeso molecular:386.76PF-04745637
CAS:<p>PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].</p>Fórmula:C27H32ClF3N2O2Pureza:98.88% - 99.3%Forma y color:SolidPeso molecular:509Oleoyl Serotonin
CAS:<p>Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.</p>Fórmula:C28H44N2O2Pureza:99.88%Forma y color:SolidPeso molecular:440.66L-R4W2
CAS:<p>Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.</p>Fórmula:C46H71N21O6Pureza:98%Forma y color:SolidPeso molecular:1014.2TRPA1-IN-2
CAS:<p>TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.</p>Fórmula:C24H25F3N4OPureza:98.05%Forma y color:SoildPeso molecular:442.48RN-1665
CAS:<p>RN-1665 is a potent and selective TRPV4 receptor antagonist.</p>Fórmula:C20H24F5N3O3S2Pureza:>99.99%Forma y color:SoildPeso molecular:513.54CBP-1008
<p>CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.</p>Forma y color:Odour SolidAP 18
CAS:<p>AP-18 is a potent and selective TRPA1 inhibitor.</p>Fórmula:C11H12ClNOPureza:99.85% - 99.96%Forma y color:SolidPeso molecular:209.67TRPM8 antagonist 3
CAS:<p>TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).</p>Fórmula:C13H12N2O4SPureza:99.74%Forma y color:SolidPeso molecular:292.31GSK2798745
CAS:<p>GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).</p>Fórmula:C25H28N6O3Forma y color:SolidPeso molecular:460.53Resolvin D2
CAS:<p>Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.</p>Fórmula:C22H32O5Pureza:98%Forma y color:SolidPeso molecular:376.49NGD-8243
CAS:<p>NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for prevention</p>Fórmula:C21H12F6N4Pureza:95.26%Forma y color:SolidPeso molecular:434.34(S)-ABT 102
CAS:<p>N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.</p>Fórmula:C21H24N4OPureza:99.65% - 99.77%Forma y color:SoildPeso molecular:348.44BTD
CAS:<p>BTD is a TRPC5 activator that activates heteromeric channel complexes composed of TRPC5 and its closest relatives TRPC1 or TRPC4.</p>Fórmula:C24H33N3O4SForma y color:SolidPeso molecular:459.6Phenazopyridine
CAS:<p>Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections,. against SARM1 and TRPM8.</p>Fórmula:C11H11N5Pureza:99.98%Forma y color:SolidPeso molecular:213.24ASP7663
CAS:<p>ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.</p>Fórmula:C14H14FNO3Pureza:98.61%Forma y color:SolidPeso molecular:263.26PF-4840154
CAS:<p>PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.</p>Fórmula:C26H38N6O2Pureza:>99.99%Forma y color:SolidPeso molecular:466.62GSK2193874
CAS:<p>GSK2193874 was identified as a selective, orally active TRPV4 blocker.</p>Fórmula:C37H38BrF3N4OPureza:98.79% - ≥95%Forma y color:SolidPeso molecular:691.62JNJ-17203212
CAS:<p>JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).</p>Fórmula:C17H15F6N5OPureza:99.18%Forma y color:SolidPeso molecular:419.32M8-B Hydrochloride
CAS:<p>M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.</p>Fórmula:C22H25ClN2O3SPureza:99.33%Forma y color:SolidPeso molecular:432.96SB-366791
CAS:<p>SB-366791 is a new and selective cinnamide TRPV1 antagonist.</p>Fórmula:C16H14ClNO2Pureza:99.51%Forma y color:SolidPeso molecular:287.74Ononetin
CAS:<p>Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).</p>Fórmula:C15H14O4Pureza:98.06%Forma y color:SolidPeso molecular:258.27Evifacotrep
CAS:<p>Evifacotrep: TRPC5 antagonist for neurological disease research (WO2020061162, compound 100).</p>Fórmula:C18H12ClF4N5O2Pureza:98.6%Forma y color:SolidPeso molecular:441.77HC067047 Hydrochloride(883031-03-6 free base)
CAS:<p>HC-067047 hydrochloride, a TRPV4 antagonist, selectively inhibits human, rat, and mouse currents with IC50s: 486 nM, 133 nM, and 17 nM.</p>Fórmula:C26H29ClF3N3O2Pureza:99.95%Forma y color:SolidPeso molecular:507.98HC-030031
CAS:<p>HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.</p>Fórmula:C18H21N5O3Pureza:99.69% - ≥95%Forma y color:SolidPeso molecular:355.39ML204
CAS:<p>ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.</p>Fórmula:C15H18N2Pureza:98.1% - 99.72%Forma y color:SolidPeso molecular:226.32RN-1734
CAS:<p>RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively)</p>Fórmula:C14H22Cl2N2O2SPureza:99.1% - 99.3%Forma y color:SolidPeso molecular:353.31AMG 333
CAS:<p>AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.</p>Fórmula:C20H12F5N3O4Pureza:99.95%Forma y color:SolidPeso molecular:453.32Chembridge-5861528
CAS:<p>Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.</p>Fórmula:C19H23N5O3Pureza:99.97%Forma y color:SolidPeso molecular:369.42RQ-00203078
CAS:<p>RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.</p>Fórmula:C21H13ClF6N2O5SPureza:98% - 99.6%Forma y color:SolidPeso molecular:554.85A-967079
CAS:<p>A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively</p>Fórmula:C12H14FNOPureza:98.34% - 99.75%Forma y color:SolidPeso molecular:207.24ICILIN
CAS:<p>ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.</p>Fórmula:C16H13N3O4Pureza:98.45% - ≥95%Forma y color:Light Yellow SolidPeso molecular:311.29HC-067047
CAS:<p>HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .</p>Fórmula:C26H28F3N3O2Pureza:99.45% - 99.97%Forma y color:SolidPeso molecular:471.51AM-0902
CAS:<p>AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).</p>Fórmula:C17H15ClN6O2Pureza:>99.99%Forma y color:SolidPeso molecular:370.79SB 452533
CAS:<p>SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).</p>Fórmula:C18H22BrN3OPureza:99.87%Forma y color:SolidPeso molecular:376.29Pico145
CAS:<p>Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.</p>Fórmula:C23H20ClF3N4O5Pureza:99.06%Forma y color:SolidPeso molecular:524.88TRPM4-IN-1
CAS:<p>TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.</p>Fórmula:C15H11Cl2NO4Pureza:97.22%Forma y color:SolidPeso molecular:340.16MK6-83
CAS:<p>MK6-83 is the transient receptor potential channel ML3 agonist.</p>Fórmula:C16H20N2O2S2Pureza:99.5%Forma y color:SolidPeso molecular:336.479-Phenanthrol
CAS:<p>9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.</p>Fórmula:C14H10OPureza:98.48%Forma y color:SolidPeso molecular:194.23TC-I2000
CAS:<p>TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.</p>Fórmula:C23H18F4N2OPureza:99.778%Forma y color:SolidPeso molecular:414.4ML204 hydrochloride
CAS:<p>ML204 hydrochloride (ML204 HCl) is a TRPC4/TRPC5 channel antagonist.</p>Fórmula:C15H19ClN2Forma y color:SolidPeso molecular:262.78WS-12
CAS:<p>WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)</p>Fórmula:C18H27NO2Pureza:99.99%Forma y color:Whitish To White Solid CrystallinePeso molecular:289.41Pyr10
CAS:<p>Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.</p>Fórmula:C18H13F6N3O2SPureza:99.69% - 99.7%Forma y color:SolidPeso molecular:449.37SB-705498
CAS:<p>SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.</p>Fórmula:C17H16BrF3N4OPureza:99.57% - ≥95%Forma y color:SolidPeso molecular:429.23Vanilloid receptor antagonist 1
CAS:<p>Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.</p>Fórmula:C18H15N3O2Pureza:98.14%Forma y color:SolidPeso molecular:305.33
