Canal TRP / TRPV
Los canales TRP (Receptor Potencial Transitorio), incluida la subfamilia TRPV, son un grupo de canales iónicos involucrados en diversos procesos sensoriales, como la sensación de temperatura, la percepción del dolor y la osmorregulación. Los canales TRP están ampliamente expresados en diferentes tejidos y desempeñan un papel en las respuestas fisiológicas a estímulos ambientales. Los canales TRPV, en particular, están involucrados en la detección de cambios de temperatura y están implicados en condiciones como el dolor crónico, la inflamación y el cáncer. En CymitQuimica, ofrecemos una gama completa de moduladores de canales TRP/TRPV para apoyar su investigación en biología sensorial, manejo del dolor y transducción de señales.
Se han encontrado 92 productos de "Canal TRP / TRPV"
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AMG9810
CAS:<p>AMG 9810 blocks capsaicin's action on TRPV1; human IC50=24.5 nM, rat IC50=85.6 nM.</p>Fórmula:C21H23NO3Pureza:99.79% - 99.95%Forma y color:SolidPeso molecular:337.41Optovin
CAS:<p>Optovin is a TRPA1 activator, which is reversibly photoactivated.</p>Fórmula:C15H13N3OS2Pureza:99.47% - 99.67%Forma y color:SolidPeso molecular:315.41MDR-652
CAS:<p>MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for</p>Fórmula:C22H23ClFN3O2SPureza:99.96%Forma y color:SolidPeso molecular:447.95RN-1747
CAS:<p>RN-1747: TRPV4 agonist (EC50: human 0.77 μM, mouse 4.0 μM, rat 4.1 μM), TRPM8 antagonist (IC50: 4 μM).</p>Fórmula:C17H18ClN3O4SPureza:99.29%Forma y color:SolidPeso molecular:395.86AMTB hydrochloride
CAS:<p>AMTB HCl: Novel TRPM8 blocker, relieves pain, treats urinary issues, moderates bladder reflexes in rats.</p>Fórmula:C23H27ClN2O2SPureza:99.08%Forma y color:SolidPeso molecular:430.99TRPM8 antagonist 2
CAS:<p>TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.</p>Fórmula:C26H26N2O2Pureza:98.1%Forma y color:SolidPeso molecular:398.5AC1903
CAS:<p>AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.</p>Fórmula:C19H17N3OPureza:98.45%Forma y color:SolidPeso molecular:303.36cim0216
CAS:<p>CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.</p>Fórmula:C21H21N3O2Pureza:99.87%Forma y color:SolidPeso molecular:347.41AMG 517
CAS:<p>AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM) and heat activation (IC50: 1.3 nM) of TRPV1</p>Fórmula:C20H13F3N4O2SPureza:99.77% - 99.85%Forma y color:SolidPeso molecular:430.4JNJ-28583113
CAS:<p>JNJ-28583113 is a TRPM2 antagonist, inducing phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death.</p>Fórmula:C19H21F3N2O2Pureza:98.57%Forma y color:SolidPeso molecular:366.38SAR7334
CAS:<p>SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).</p>Fórmula:C21H22ClN3OPureza:99.62% - 99.71%Forma y color:SolidPeso molecular:367.87JYL 1421
CAS:<p>JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).</p>Fórmula:C20H26FN3O2S2Pureza:98.83%Forma y color:SolidPeso molecular:423.57TRPC6-PAM-C20
CAS:<p>TRPC6-PAM-C20, a selective enhancer for TRPC6, boosts calcium in HEK cells and OAG-related platelet clumping, EC50: 2.37μM.</p>Fórmula:C22H21NO4Pureza:98.16%Forma y color:SolidPeso molecular:363.41AM12
CAS:<p>AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).</p>Fórmula:C15H9BrO5Pureza:98%Forma y color:SolidPeso molecular:349.13D-3263 hydrochloride
CAS:<p>D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.</p>Fórmula:C21H32ClN3O3Pureza:99.93%Forma y color:SolidPeso molecular:409.95TRPM4-IN-2
CAS:<p>NBA, or TRPM4-IN-2, is a potent TRPM4 inhibitor with IC50 of 0.16 μM, used in prostate and colorectal cancer research.</p>Fórmula:C19H14ClNO4Pureza:99.21%Forma y color:SolidPeso molecular:355.77Asivatrep
CAS:<p>Asivatrep (PAC14028) is a selective and potent antagonist of transient receptor potential vanilloid subtype 1 (TRPV1) for the study of atopic dermatitis.</p>Fórmula:C21H22F5N3O3SPureza:95.13%Forma y color:SolidPeso molecular:491.48TRPV3 antagonist 74a
CAS:<p>TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.</p>Fórmula:C17H17F3N2O2Pureza:≥98.0%Forma y color:SolidPeso molecular:338.32RN9893
CAS:<p>RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.</p>Fórmula:C21H23F3N4O5SPureza:99.89%Forma y color:SolidPeso molecular:500.49TRPV4 agonist-1
CAS:<p>TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).</p>Fórmula:C25H23ClF2N4O2Pureza:98%Forma y color:SolidPeso molecular:484.93Motugivatrep
CAS:<p>Motugivatrep is a potent and selective TRPV1 antagonist that can be used to study TRPV1-related respiratory diseases.</p>Fórmula:C22H20F3NO3Pureza:99.22%Forma y color:SolidPeso molecular:403.39GSK1702934A
CAS:<p>GSK1702934A is a TRPC3 agonist with pro-arrhythmic and positive inotropic effects and is used in the study of diabetes mellitus.</p>Fórmula:C22H25N3O2SPureza:98.15%Forma y color:SolidPeso molecular:395.52ABT 102
CAS:<p>ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.</p>Fórmula:C21H24N4OPureza:98.38% - 99.86%Forma y color:SolidPeso molecular:348.44Mavatrep
CAS:<p>Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain.</p>Fórmula:C25H21F3N2OPureza:98.51% - 99.31%Forma y color:SolidPeso molecular:422.44SET 2
CAS:<p>SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.</p>Fórmula:C17H21F3N4O2SPureza:99.77%Forma y color:SolidPeso molecular:402.43Elismetrep
CAS:<p>Elismetrep (MT-8554) is an orally available TRPM8 inhibitor with potential analgesic activity for the study of vasomotor symptoms in postmenopausal women.</p>Fórmula:C27H21F3N2O5SPureza:99.37% - 99.93%Forma y color:SolidPeso molecular:542.53MSP3
CAS:<p>MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.</p>Fórmula:C16H19NO3SPureza:99.89%Forma y color:SolidPeso molecular:305.39HC-070
CAS:<p>HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).</p>Fórmula:C22H20Cl2N4O4Pureza:98.48%Forma y color:SolidPeso molecular:475.32Pyr3
CAS:<p>Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.</p>Fórmula:C16H11Cl3F3N3O3Pureza:98.04%Forma y color:SolidPeso molecular:456.63TC-I 2014
CAS:<p>TC-I 2014 shows antiallodynic properties in pain models.</p>Fórmula:C23H19F6N3OPureza:99.07%Forma y color:SolidPeso molecular:467.41Olvanil
CAS:<p>Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.</p>Fórmula:C26H43NO3Pureza:99.58%Forma y color:SolidPeso molecular:417.62FEMA-4809
CAS:<p>FEMA-4809 activates TRPM8, the ion channel for cold sensation, and is used as a cooling agent.</p>Fórmula:C17H17N3O2SPureza:99.9%Forma y color:SolidPeso molecular:327.4Mesendogen
CAS:<p>Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7</p>Fórmula:C18H16ClF3N2OSPureza:99.66%Forma y color:SolidPeso molecular:400.85MK-2295
CAS:<p>MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.</p>Fórmula:C27H31FN6O2Pureza:98.83% - 99.44%Forma y color:SolidPeso molecular:490.57A-1165442
CAS:<p>A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.</p>Fórmula:C22H20ClF2N3O2Forma y color:SolidPeso molecular:431.86GSK3395879
CAS:<p>GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).</p>Fórmula:C20H15F4N3O5SPureza:98%Forma y color:SolidPeso molecular:485.41PF-05105679
CAS:<p>PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.</p>Fórmula:C26H21FN2O3Pureza:99.84%Forma y color:SolidPeso molecular:428.45JT010
CAS:<p>JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).</p>Fórmula:C16H19ClN2O3SPureza:99.75%Forma y color:SolidPeso molecular:354.85AMG-0347
CAS:<p>AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.</p>Fórmula:C24H26F3N3O2Pureza:99.93%Forma y color:SolidPeso molecular:445.48AMG2850
CAS:<p>AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).</p>Fórmula:C19H17F6N3OPureza:99.84%Forma y color:SolidPeso molecular:417.35TRPA1 Antagonist 1
CAS:<p>TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.</p>Fórmula:C24H20F6N5Na2O7PSPureza:98%Forma y color:SolidPeso molecular:713.45Apcin A HCL
CAS:<p>Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].</p>Fórmula:C10H15Cl4N5O2Pureza:99.30%Forma y color:SolidPeso molecular:379.07
