Canal TRP / TRPV
Los canales TRP (Receptor Potencial Transitorio), incluida la subfamilia TRPV, son un grupo de canales iónicos involucrados en diversos procesos sensoriales, como la sensación de temperatura, la percepción del dolor y la osmorregulación. Los canales TRP están ampliamente expresados en diferentes tejidos y desempeñan un papel en las respuestas fisiológicas a estímulos ambientales. Los canales TRPV, en particular, están involucrados en la detección de cambios de temperatura y están implicados en condiciones como el dolor crónico, la inflamación y el cáncer. En CymitQuimica, ofrecemos una gama completa de moduladores de canales TRP/TRPV para apoyar su investigación en biología sensorial, manejo del dolor y transducción de señales.
Se han encontrado 111 productos para "Canal TRP / TRPV".
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BI-749327
CAS:BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).Fórmula:C23H21F3N4O2Pureza:99.68% - 99.84%Forma y color:SolidPeso molecular:442.4336Ref: TM-T10537
1mg126,00€2mg168,00€5mg260,00€1mL*10mM (DMSO)285,00€10mg409,00€25mg597,00€50mg782,00€100mg1.044,00€500mg2.088,00€GFB-8438
CAS:GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).Fórmula:C16H14ClF3N4O2Pureza:99.58%Forma y color:SolidPeso molecular:386.756Vocacapsaicin hydrochloride
CAS:Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.Fórmula:C26H42ClN3O4Pureza:99.66% - 99.80%Forma y color:SolidPeso molecular:496.08TRPV4 agonist-1 free base
CAS:TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).Fórmula:C25H22F2N4O2Pureza:99.79%Forma y color:SolidPeso molecular:448.4646IA-Alkyne
CAS:IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.Fórmula:C8H12INOPureza:99.76%Forma y color:White SolidPeso molecular:265.091Ref: TM-T15543
1mg56,00€1mL*10mM (DMSO)114,00€5mg119,00€10mg177,00€25mg250,00€50mg313,00€100mg432,00€TRPV4 antagonist 5
CAS:TRPV4 antagonist 5(GSK2798745 derivatives) are solid-form derivatives of GSK2798745, selective TRPV4 blockers and antagonists for cardiac and respiratory disorders.Fórmula:C25H27PN6O3Pureza:98.80% - 99.40%Forma y color:Yellow SolidPeso molecular:478.53(Iso)-TRPV4 antagonist 5
CAS:(Iso)-TRPV4 antagonist 5 are selective oral TRPV4 blockers for pulmonary edema research.Fórmula:C25H27FN6O3Pureza:99.23% - 99.63%Peso molecular:478.52PF-04745637
CAS:PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].Fórmula:C27H32ClF3N2O2Pureza:98.39% - 98.88%Forma y color:SolidPeso molecular:509.003Cyclic ADP-Ribose (ammonium salt)
Cyclic ADP-Ribose (ammonium salt) (cADPR) is an NAD⁺ metabolite that triggers Ca²⁺ release from ER stores via ryanodine receptors, relevant to inflammation research.Fórmula:C15H21N5O13P2·xNH3Forma y color:White SolidCBP-1018
CAS:CBP-1018 is a peptide-drug conjugate (PDC) composed of a dual-targeting ligand for FRα/TRPV6, linked to Monomethylauristatin E. It holds promise for research in the field of breast cancer.Fórmula:C132H192N30O38SPeso molecular:2839.18L-R4W2
CAS:Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.Fórmula:C46H71N21O6Pureza:98%Forma y color:SolidPeso molecular:1014.2CBP-1008
CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.Forma y color:Odour SolidTRPM8 antagonist 3
CAS:TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).Fórmula:C13H12N2O4SPureza:99.74%Forma y color:White SolidPeso molecular:292.31Oleoyl Serotonin
CAS:Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.Fórmula:C28H44N2O2Pureza:99.88%Forma y color:SolidPeso molecular:440.6612(S)-ABT 102
CAS:N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.Fórmula:C21H24N4OPureza:99.65% - 99.77%Forma y color:White SolidPeso molecular:348.4415Ref: TM-T29522L
1mg73,00€5mg149,00€1mL*10mM (DMSO)154,00€10mg212,00€25mg319,00€50mg447,00€100mg610,00€200mg822,00€TRPV1 antagonist 6
TRPV1 antagonist 6 (compound 51) is a modality-selective TRPV1 antagonist that exhibits antagonistic activity against capsaicin activation with an IC50 of 2.85 nM and demonstrates an inhibition rate of 28.48% against proton activation at a concentration of 3 µM.Fórmula:C26H28ClN5O3Peso molecular:493.18807AP 18
CAS:AP-18 is a potent and selective TRPA1 inhibitor.Fórmula:C11H12ClNOPureza:99.76% - 99.96%Forma y color:SolidPeso molecular:209.67Ref: TM-T21543
5mg46,00€1mL*10mM (DMSO)48,00€10mg66,00€25mg114,00€50mg177,00€100mg286,00€200mg425,00€TRPA1-IN-2
CAS:TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.Fórmula:C24H25F3N4OPureza:98.93%Forma y color:SoildPeso molecular:442.48Ref: TM-T77511
1mg56,00€5mg129,00€1mL*10mM (DMSO)142,00€10mg188,00€25mg319,00€50mg447,00€100mg600,00€200mg807,00€RN-1665
CAS:RN-1665 is a potent and selective TRPV4 receptor antagonist.Fórmula:C20H24F5N3O3S2Pureza:99.96%Forma y color:SoildPeso molecular:513.54NGD-8243
CAS:NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for preventionFórmula:C21H12F6N4Pureza:95.26%Forma y color:White SolidPeso molecular:434.3372
