Canal de potasio
Los canales de potasio son un grupo diverso de proteínas de membrana que facilitan el flujo de iones de potasio (K+) a través de la membrana celular. Estos canales desempeñan un papel crucial en el mantenimiento del potencial de membrana en reposo, la regulación del volumen celular y el control de la excitabilidad de las neuronas y las células musculares. Los canales de potasio están involucrados en varios procesos fisiológicos, incluyendo la regulación del ritmo cardíaco, la secreción de insulina y la liberación de neurotransmisores. La disfunción de los canales de potasio está relacionada con condiciones como arritmias, epilepsia e hipertensión. En CymitQuimica, ofrecemos una amplia gama de moduladores de canales de potasio para apoyar su investigación en electrofisiología, salud cardiovascular y neurobiología.
Se han encontrado 276 productos de "Canal de potasio"
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BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Fórmula:C22H23F7N2O3Forma y color:SolidPeso molecular:496.418Agitoxin-2
CAS:<p>Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).</p>Fórmula:C169H278N54O48S8Pureza:98%Forma y color:SolidPeso molecular:4090.87Ebio2
<p>Ebio2 is an effective activator of KCNQ2.</p>Fórmula:C17H19F2N3O2Forma y color:SolidPeso molecular:335.349Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Fórmula:C79H131N31O24S4Pureza:98%Forma y color:SolidPeso molecular:2027.34MASP-2-IN-1
<p>MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.</p>Fórmula:C22H21N7O3SForma y color:SolidPeso molecular:463.512Margatoxin
CAS:<p>KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.</p>Fórmula:C178H286N52O50S7Pureza:98%Forma y color:SolidPeso molecular:4178.96Charybdotoxin
CAS:<p>Specific inhibitor of the big conductance Ca2+-activated K+ channel.</p>Fórmula:C176H277N57O55S7Pureza:98%Forma y color:SolidPeso molecular:4295.95KCNQ1 activator-1
CAS:<p>N-[4-(4-Methoxyphenyl)-2-thiazolyl]-2-piperidinecarboxamide is a potent KCNQ1 activator for LQTS research.</p>Fórmula:C22H23N3O4S2Pureza:99.71%Forma y color:SolidPeso molecular:457.57Cromakalim
CAS:<p>Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.</p>Fórmula:C16H18N2O3Pureza:99.39%Forma y color:SolidPeso molecular:286.33Neosolaniol
CAS:<p>Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.</p>Fórmula:C19H26O8Pureza:98%Forma y color:SolidPeso molecular:382.4Endoxifen Z-isomer hydrochloride
CAS:<p>Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.</p>Fórmula:C25H28ClNO2Forma y color:SolidPeso molecular:409.95Nateglinide D5
CAS:<p>Nateglinide D5 is a deuterium labeled Nateglinide.</p>Fórmula:C19H27NO3Pureza:98%Forma y color:SolidPeso molecular:322.45Clamikalant sodium
CAS:<p>Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.</p>Fórmula:C19H21ClN3NaO5S2Pureza:99.95%Forma y color:SolidPeso molecular:493.96Flecainide
CAS:<p>Flecainide is an orally administered antiarrhythmic agent acting as a sodium channel blocker and IKr inhibitor,PSVT.</p>Fórmula:C17H20F6N2O3Pureza:99.896%Forma y color:SolidPeso molecular:414.34QO-58
CAS:<p>QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, danti-nociceptive effects on inflammatory pain</p>Fórmula:C18H8Cl2F4N4OPureza:99.17%Forma y color:SolidPeso molecular:443.18Almitrine mesylate
CAS:<p>Almitrine mesylate targets Ca2+-dependent K+ channels in rat cells, used for chronic lung hypoxemia.</p>Fórmula:C28H37F2N7O6S2Pureza:99.96%Forma y color:CoaPeso molecular:669.76TKIM
CAS:<p>TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.</p>Fórmula:C18H14ClN3O2SPureza:99.47%Forma y color:SolidPeso molecular:371.84Kv2-IN-A1
CAS:<p>Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.</p>Fórmula:C20H17ClN4OSPureza:98.83%Forma y color:SolidPeso molecular:396.89E-4031 dihydrochloride
CAS:<p>E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)</p>Fórmula:C21H29Cl2N3O3SPureza:99.31% - 99.87%Forma y color:SolidPeso molecular:474.44Amifampridine
CAS:<p>Amifampridine blocks nerve potassium channels, extends action potentials, boosts acetylcholine release, and treats rare muscle diseases.</p>Fórmula:C5H7N3Pureza:99.82%Forma y color:Slightly Beige PowderPeso molecular:109.13
