Canal de potasio
Los canales de potasio son un grupo diverso de proteínas de membrana que facilitan el flujo de iones de potasio (K+) a través de la membrana celular. Estos canales desempeñan un papel crucial en el mantenimiento del potencial de membrana en reposo, la regulación del volumen celular y el control de la excitabilidad de las neuronas y las células musculares. Los canales de potasio están involucrados en varios procesos fisiológicos, incluyendo la regulación del ritmo cardíaco, la secreción de insulina y la liberación de neurotransmisores. La disfunción de los canales de potasio está relacionada con condiciones como arritmias, epilepsia e hipertensión. En CymitQuimica, ofrecemos una amplia gama de moduladores de canales de potasio para apoyar su investigación en electrofisiología, salud cardiovascular y neurobiología.
Se han encontrado 276 productos de "Canal de potasio"
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Rosuvastatin
CAS:<p>Rosuvastatin (ZD4522) is an inhibitor of HMG-CoA reductase (HMGCR). Rosuvastatin has hypolipidemic and antiatherosclerotic effects. Cost-effective and quality-assured.</p>Fórmula:C22H28FN3O6SPureza:95.24% - 99.8%Forma y color:SolidPeso molecular:481.54Levosimendan
CAS:<p>Levosimendan (OR1259) is a calcium sensitizer for acute heart failure, enhancing cardiac contractility without raising calcium levels.</p>Fórmula:C14H12N6OPureza:99.37% - 99.91%Forma y color:Yellow Crystalline PowderPeso molecular:280.28QO-40
CAS:<p>QO-40 is a KCNQ2/3 potassium channels activator.</p>Fórmula:C18H11ClF3N3OPureza:99.57%Forma y color:SolidPeso molecular:377.75H3B-120
CAS:<p>H3B-120: selective, competitive CPS1 inhibitor with anti-cancer properties. IC50: 1.5 μM, Ki: 1.4 μM.</p>Fórmula:C19H24N4O2SPureza:99.03% - 99.2%Forma y color:SolidPeso molecular:372.48CLP290
CAS:<p>CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric</p>Fórmula:C19H21FN4O3SPureza:99.93% - >99.99%Forma y color:SolidPeso molecular:404.46BMS-191011
CAS:<p>BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models</p>Fórmula:C16H10ClF3N2O3Pureza:97.43%Forma y color:SolidPeso molecular:370.71Tetrandrine
CAS:<p>Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Cost-effective and quality-assured.</p>Fórmula:C38H42N2O6Pureza:99.61% - 99.94%Forma y color:White SolidPeso molecular:622.75BL-1249
CAS:<p>BL-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2).</p>Fórmula:C17H17N5Pureza:98% - 98.25%Forma y color:SolidPeso molecular:291.35VU590
CAS:<p>VU590 is an inhibitor of extrarenal medullary potassium ROMK.VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.</p>Fórmula:C24H32N4O7Pureza:98.06%Forma y color:SolidPeso molecular:488.53HUP30
CAS:<p>HUP30 is a potent vasodilating agent. HUP30 can stimulate soluble guanylyl cyclase, activate K+ channels, and block extracellular Ca2+ influx.</p>Fórmula:C14H15N3O3SPureza:99.96%Forma y color:SolidPeso molecular:305.35Doxapram
CAS:<p>Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels.</p>Fórmula:C24H30N2O2Pureza:99.42%Forma y color:SolidPeso molecular:378.51Dofetilide D4
CAS:<p>Dofetilide D4 (UK 68789 D4), a deuterium-labeled version of Dofetilide, is categorized as a Class III antiarrhythmic medication.</p>Fórmula:C19H27N3O5S2Pureza:98%Forma y color:SolidPeso molecular:445.59Repaglinide D5
CAS:<p>Repaglinide D5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for treatment type-2 diabetes mellitus.</p>Fórmula:C27H36N2O4Pureza:98%Forma y color:SolidPeso molecular:457.62LY 303511
CAS:<p>LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.</p>Fórmula:C19H18N2O2Pureza:98%Forma y color:SolidPeso molecular:306.36Meclofenamic acid
CAS:<p>Meclofenamic acid: non-selective gap-junction blocker, FTO inhibitor, anti-inflammatory.</p>Fórmula:C14H11Cl2NO2Pureza:98%Forma y color:SolidPeso molecular:296.15AVE-0118
CAS:<p>AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.</p>Fórmula:C30H29N3O3Pureza:97.04% - 98.93%Forma y color:SolidPeso molecular:479.57ML402
CAS:<p>ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.</p>Fórmula:C14H14ClNO2SPureza:99.71%Forma y color:SolidPeso molecular:295.78ICA
CAS:<p>ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).</p>Fórmula:C13H10N4SPureza:99.68%Forma y color:SolidPeso molecular:254.31UK 78282 hydrochloride
CAS:<p>UK-78282 hydrochloride, a Kv1.3 blocker.UK-78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.</p>Fórmula:C29H36ClNO2Pureza:99.68%Forma y color:SolidPeso molecular:466.05TWIK-1/TREK-1-IN-2
CAS:<p>TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 values</p>Fórmula:C20H29F3N2O2Pureza:98%Forma y color:SolidPeso molecular:386.45B-TPMF
CAS:<p>B-TPMF is a highly efficient and selective KCa2.1 channel inhibitor with an IC50 of 31 nM, interacting with serine residue at position 293 to inhibit KCa2.1.</p>Fórmula:C19H24N6O2Pureza:99.82%Forma y color:SolidPeso molecular:368.43SCH-23390 maleate
CAS:<p>SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM,</p>Fórmula:C21H22ClNO5Pureza:98%Forma y color:SolidPeso molecular:403.86Vernakalant
CAS:<p>Vernakalant (RSD-1235) is a mixed ion channel blocker.</p>Fórmula:C20H31NO4Pureza:98%Forma y color:SolidPeso molecular:349.46CM-TPMF
CAS:<p>CM-TPMF is a highly efficient and potent activator of the K(Ca)2.1 channel, Ser293 in the transmembrane segment 5, neurological disorders.</p>Fórmula:C16H17ClN6O2Pureza:99.94%Forma y color:SolidPeso molecular:360.8HN37
CAS:<p>HN37, KCNQ2 activator (EC50=37 nM). Affordable Excellence: Reliable Quality You Can Trust</p>Fórmula:C20H21FN2O2Pureza:99.27%Forma y color:SolidPeso molecular:340.39Pinacidil
CAS:<p>Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and</p>Fórmula:C13H19N5Pureza:99.9%Forma y color:SolidPeso molecular:245.32VU0405601
CAS:<p>VU0405601 is a hERG channel activator that protects against drug-induced cardiac arrhythmias.</p>Fórmula:C17H13BrN2O2Pureza:99.16%Forma y color:SolidPeso molecular:357.2Nifekalant hydrochloride
CAS:<p>Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM.</p>Fórmula:C19H28ClN5O5Pureza:99.91%Forma y color:SolidPeso molecular:441.91Almokalant
CAS:<p>Almokalant: Class III antiarrhythmic, K+ channel blocker, inhibits Ikr current.</p>Fórmula:C18H28N2O3SPureza:98%Forma y color:SolidPeso molecular:352.49Aprikalim
CAS:<p>Aprikalim opens KATP channels, protects the heart, and at high doses, dilates blood vessels.</p>Fórmula:C12H16N2OS2Pureza:99.42% - 99.90%Forma y color:SolidPeso molecular:268.4TWIK-1/TREK-1-IN-1
CAS:<p>Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and</p>Fórmula:C21H24F3NO3Pureza:98%Forma y color:SolidPeso molecular:395.42AVE1231
CAS:<p>AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation.</p>Fórmula:C20H27N3O4SPureza:98.03%Forma y color:SolidPeso molecular:405.51GAL-021 sulfate
CAS:<p>GAL-021 sulfate is a BKCa channel blocker that inhibits the analgesic effects of opioids and is used in the study of respiratory control diseases.</p>Fórmula:C11H24N6O5SPureza:99.92%Forma y color:SolidPeso molecular:352.41TRAM 39
CAS:<p>TRAM 39 (2-Chloro-α,α-diphenylbenzeneacetonitrile) is a selective blocker of intermediate-conductance Ca2+-activated K+channels.</p>Fórmula:C20H14ClNPureza:99.97%Forma y color:SolidPeso molecular:303.78RY796
CAS:<p>RY796 is a selective voltage-gated potassium (KV2) channel inhibitor that inhibits KV2.1 and KV2.2, used in research on neurological disorders.</p>Fórmula:C21H27N3O2Pureza:98.59%Forma y color:SolidPeso molecular:353.46Psora 4
CAS:<p>Psora 4 (5-(4-Phenylbutoxy)psoralen) is a Kv1.3 blocker and a caloric restriction mimetic.</p>Fórmula:C21H18O4Forma y color:SolidPeso molecular:334.37Vernakalant Hydrochloride
CAS:<p>Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.</p>Fórmula:C20H32ClNO4Pureza:99.89%Forma y color:SolidPeso molecular:385.93Amsacrine
CAS:<p>Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.</p>Fórmula:C21H19N3O3SPureza:99.2%Forma y color:Yellow Crystalline Powder SolidPeso molecular:393.46DMP-543
CAS:<p>DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters.</p>Fórmula:C26H18F2N2OPureza:99.89%Forma y color:SolidPeso molecular:412.43TASK-1-IN-1
CAS:<p>TASK-1-IN-1: Potent, selective TASK-1 blocker (IC50: 148 nM), weaker on TASK-3 (IC50: 1750 nM), anticancer properties.</p>Fórmula:C22H20N2O2Pureza:99.57%Forma y color:SoildPeso molecular:344.41MK-0448
CAS:<p>MK-0448 is a novel and selective blocker of the Kv1.5 (KCNA5) channel, a key channel involved in cardiac repolarization current I Kur.</p>Fórmula:C24H21FN4O2SPureza:99.25% - 99.79%Forma y color:SolidPeso molecular:448.51CyPPA
CAS:<p>CyPPA enhances SK channels, reducing firing rate and extending apamin-sensitive afterhyperpolarization.</p>Fórmula:C16H23N5Pureza:99.88%Forma y color:SolidPeso molecular:285.39Sipatrigine
CAS:<p>Sipatrigine (619C89) is an inhibitor of glutamate release, TREK ion channels, TRESK channels, sodium channels, and calcium channels.</p>Fórmula:C15H16Cl3N5Pureza:98.64% - 99.77%Forma y color:SolidPeso molecular:372.68RL648_81
CAS:<p>RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.</p>Fórmula:C17H17F4N3O2Pureza:99.82%Forma y color:SolidPeso molecular:371.33SKA-111
CAS:<p>SKA-111 activates KCa3.1 potassium channels, modulates membrane potential in endothelial cells, and dilates rat coronary arteries.</p>Fórmula:C12H10N2SPureza:99.9%Forma y color:SolidPeso molecular:214.29ZTZ240
CAS:<p>ZTZ240 is a KCNQ2 channel activator used in the study of epilepsy.</p>Fórmula:C12H8ClFN2OPureza:99.89%Forma y color:SolidPeso molecular:250.66ZM 226600
CAS:<p>ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.</p>Fórmula:C16H14F3NO4SPureza:99.87%Forma y color:SolidPeso molecular:373.35PD-118057
CAS:<p>PD-118057, a potent hERG activator, may treat long QT syndrome and heart failure without hERG activity inhibition.</p>Fórmula:C21H17Cl2NO2Pureza:99.16% - 99.97%Forma y color:SolidPeso molecular:386.27UK 66914
CAS:<p>UK 66914 is a K(+) channel blocker for the study of cardiac arrhythmias.</p>Fórmula:C18H24N4O3SPureza:99.75%Forma y color:SolidPeso molecular:376.47(+)-KCC2 blocker 1
CAS:<p>(+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM).</p>Fórmula:C22H25NO5SPureza:99.88%Forma y color:SolidPeso molecular:415.5GW 542573X
CAS:<p>GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.GW 542573X induces a leftward shift in the Ca2+ response curve</p>Fórmula:C19H28N2O5Pureza:99.91%Forma y color:SolidPeso molecular:364.44XE991
CAS:<p>XE991 is a Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1) and M-current and can be used in the study of neurological disorders.</p>Fórmula:C26H20N2OPureza:98.87%Forma y color:SolidPeso molecular:376.45TWIK-1/TREK-1-IN-3
CAS:<p>TWIK-1/TREK-1-IN-3 is a potassium channel TREK-1 inhibitor TWIK-1/TREK-1-IN-3 has antidepressant activity and can be used to study depression.</p>Fórmula:C19H27F3N2O2Pureza:99.04%Forma y color:SolidPeso molecular:372.43IKs124
CAS:<p>IKs124 is a KCNE2/KCNQ1 potassium channel blocker, for hKCNE1 and hKCNE3, and can be used to study peptic ulcers.</p>Fórmula:C18H26N2O3SPureza:99.53%Forma y color:SolidPeso molecular:350.48KT-362 fumarate
CAS:<p>KT-362 fumarate, a novel antagonist of Ca, K, and Na channels, induces vasodilation and relaxes rabbit arterial strips.</p>Fórmula:C26H32N2O7SPureza:99.75% - 99.98%Forma y color:SolidPeso molecular:516.61JNJ-26489112
CAS:<p>JNJ-26489112 is a CNS-active agent and an inhibitor of voltage-gated Na+ channels and N-type Ca2+ channels.</p>Fórmula:C9H11ClN2O4SPureza:99.31%Forma y color:SolidPeso molecular:278.71Linaprazan
CAS:<p>Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.</p>Fórmula:C21H26N4O2Pureza:99.54%Forma y color:SolidPeso molecular:366.46DPO-1
CAS:<p>DPO-1 可以高效抑制电压门控钾离子通道Kv1.5，也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。</p>Fórmula:C22H29OPPureza:99.78%Forma y color:SolidPeso molecular:340.44Clobutinol hydrochloride
CAS:<p>Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].</p>Fórmula:C14H23Cl2NOPureza:98%Forma y color:SolidPeso molecular:292.25VU0463271
CAS:<p>VU0463271: KCC2 antagonist, IC50 61 nM, >100x selective over NKCC1, inactive on other GPCRs, channels, transporters.</p>Fórmula:C19H18N4OS2Pureza:97.84% - 99.55%Forma y color:SolidPeso molecular:382.511-deoxy-PGF2a
CAS:<p>11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contraction</p>Fórmula:C20H34O4Forma y color:SolidPeso molecular:338.48Glibornuride
CAS:<p>Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).</p>Fórmula:C18H26N2O4SPureza:99.5%Forma y color:SolidPeso molecular:366.48Sigma-1 receptor antagonist 3
CAS:<p>Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).</p>Fórmula:C19H23ClFN3OPureza:99.95%Forma y color:SolidPeso molecular:363.86CLP257
CAS:<p>CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.</p>Fórmula:C14H14FN3O2SPureza:99.5%Forma y color:SolidPeso molecular:307.34MCHR1 antagonist 2
CAS:<p>MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.</p>Fórmula:C23H21FN2O5Pureza:98.29%Forma y color:SolidPeso molecular:424.42P-1075
CAS:<p>P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.</p>Fórmula:C12H17N5Pureza:99.85%Forma y color:SolidPeso molecular:231.3C 101248
CAS:<p>C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.</p>Fórmula:C15H12N6OPureza:99.14% - 99.31%Forma y color:SolidPeso molecular:292.3Kv3 modulator 1
CAS:<p>Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.</p>Fórmula:C20H20N4O4Pureza:99.41%Forma y color:SolidPeso molecular:380.4Kv7.2/Kv7.3 agonist 1
CAS:<p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>Fórmula:C14H14FN3O2Forma y color:SolidPeso molecular:275.28KCC2 Modulator-2
CAS:<p>KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.</p>Fórmula:C35H45N5O3Forma y color:SolidPeso molecular:583.76KV1.3-IN-2
CAS:<p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>Fórmula:C16H23ClN2O4Forma y color:SolidPeso molecular:342.818cis-KV1.3-IN-1
CAS:<p>cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.</p>Fórmula:C23H30N2O4SForma y color:SolidPeso molecular:430.56Kv7.2/Kv7.3 modulator-1
CAS:<p>Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.</p>Fórmula:C20H21F4N3O3Forma y color:SolidPeso molecular:427.393Opakalim
CAS:<p>Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.</p>Fórmula:C18H22F2N4OForma y color:SolidPeso molecular:348.39Kv7.2/Kv7.3 activator-1
CAS:<p>Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.</p>Fórmula:C19H22F2N4OForma y color:SolidPeso molecular:360.40Indapamide
CAS:<p>Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.</p>Fórmula:C16H16ClN3O3SPureza:98.97% - 99.83%Forma y color:SolidPeso molecular:365.83Ref: TM-T1498
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