Canal de potasio
Los canales de potasio son un grupo diverso de proteínas de membrana que facilitan el flujo de iones de potasio (K+) a través de la membrana celular. Estos canales desempeñan un papel crucial en el mantenimiento del potencial de membrana en reposo, la regulación del volumen celular y el control de la excitabilidad de las neuronas y las células musculares. Los canales de potasio están involucrados en varios procesos fisiológicos, incluyendo la regulación del ritmo cardíaco, la secreción de insulina y la liberación de neurotransmisores. La disfunción de los canales de potasio está relacionada con condiciones como arritmias, epilepsia e hipertensión. En CymitQuimica, ofrecemos una amplia gama de moduladores de canales de potasio para apoyar su investigación en electrofisiología, salud cardiovascular y neurobiología.
Se han encontrado 276 productos de "Canal de potasio"
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GW 542573X
CAS:<p>GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.GW 542573X induces a leftward shift in the Ca2+ response curve</p>Fórmula:C19H28N2O5Pureza:99.91%Forma y color:SolidPeso molecular:364.44XE991
CAS:<p>XE991 is a Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1) and M-current and can be used in the study of neurological disorders.</p>Fórmula:C26H20N2OPureza:98.87%Forma y color:SolidPeso molecular:376.45TWIK-1/TREK-1-IN-3
CAS:<p>TWIK-1/TREK-1-IN-3 is a potassium channel TREK-1 inhibitor TWIK-1/TREK-1-IN-3 has antidepressant activity and can be used to study depression.</p>Fórmula:C19H27F3N2O2Pureza:99.04%Forma y color:SolidPeso molecular:372.43IKs124
CAS:<p>IKs124 is a KCNE2/KCNQ1 potassium channel blocker, for hKCNE1 and hKCNE3, and can be used to study peptic ulcers.</p>Fórmula:C18H26N2O3SPureza:99.53%Forma y color:SolidPeso molecular:350.48KT-362 fumarate
CAS:<p>KT-362 fumarate, a novel antagonist of Ca, K, and Na channels, induces vasodilation and relaxes rabbit arterial strips.</p>Fórmula:C26H32N2O7SPureza:99.75% - 99.98%Forma y color:SolidPeso molecular:516.61JNJ-26489112
CAS:<p>JNJ-26489112 is a CNS-active agent and an inhibitor of voltage-gated Na+ channels and N-type Ca2+ channels.</p>Fórmula:C9H11ClN2O4SPureza:99.31%Forma y color:SolidPeso molecular:278.71Linaprazan
CAS:<p>Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.</p>Fórmula:C21H26N4O2Pureza:99.54%Forma y color:SolidPeso molecular:366.46DPO-1
CAS:<p>DPO-1 可以高效抑制电压门控钾离子通道Kv1.5，也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。</p>Fórmula:C22H29OPPureza:99.78%Forma y color:SolidPeso molecular:340.44Clobutinol hydrochloride
CAS:<p>Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].</p>Fórmula:C14H23Cl2NOPureza:98%Forma y color:SolidPeso molecular:292.25VU0463271
CAS:<p>VU0463271: KCC2 antagonist, IC50 61 nM, >100x selective over NKCC1, inactive on other GPCRs, channels, transporters.</p>Fórmula:C19H18N4OS2Pureza:97.84% - 99.55%Forma y color:SolidPeso molecular:382.511-deoxy-PGF2a
CAS:<p>11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contraction</p>Fórmula:C20H34O4Forma y color:SolidPeso molecular:338.48Glibornuride
CAS:<p>Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).</p>Fórmula:C18H26N2O4SPureza:99.5%Forma y color:SolidPeso molecular:366.48Sigma-1 receptor antagonist 3
CAS:<p>Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).</p>Fórmula:C19H23ClFN3OPureza:99.95%Forma y color:SolidPeso molecular:363.86CLP257
CAS:<p>CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.</p>Fórmula:C14H14FN3O2SPureza:99.5%Forma y color:SolidPeso molecular:307.34MCHR1 antagonist 2
CAS:<p>MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.</p>Fórmula:C23H21FN2O5Pureza:98.29%Forma y color:SolidPeso molecular:424.42P-1075
CAS:<p>P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.</p>Fórmula:C12H17N5Pureza:99.85%Forma y color:SolidPeso molecular:231.3C 101248
CAS:<p>C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.</p>Fórmula:C15H12N6OPureza:99.14% - 99.31%Forma y color:SolidPeso molecular:292.3Kv3 modulator 1
CAS:<p>Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.</p>Fórmula:C20H20N4O4Pureza:99.41%Forma y color:SolidPeso molecular:380.4Kv7.2/Kv7.3 agonist 1
CAS:<p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>Fórmula:C14H14FN3O2Forma y color:SolidPeso molecular:275.28KCC2 Modulator-2
CAS:<p>KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.</p>Fórmula:C35H45N5O3Forma y color:SolidPeso molecular:583.76KV1.3-IN-2
CAS:<p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>Fórmula:C16H23ClN2O4Forma y color:SolidPeso molecular:342.818cis-KV1.3-IN-1
CAS:<p>cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.</p>Fórmula:C23H30N2O4SForma y color:SolidPeso molecular:430.56Kv7.2/Kv7.3 modulator-1
CAS:<p>Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.</p>Fórmula:C20H21F4N3O3Forma y color:SolidPeso molecular:427.393Opakalim
CAS:<p>Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.</p>Fórmula:C18H22F2N4OForma y color:SolidPeso molecular:348.39Kv7.2/Kv7.3 activator-1
CAS:<p>Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.</p>Fórmula:C19H22F2N4OForma y color:SolidPeso molecular:360.40Indapamide
CAS:<p>Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.</p>Fórmula:C16H16ClN3O3SPureza:98.97% - 99.83%Forma y color:SolidPeso molecular:365.83Ref: TM-T1498
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