Canal de cloruro
Los canales de cloruro son proteínas de membrana que controlan el movimiento de los iones de cloruro a través de las membranas celulares, desempeñando un papel vital en el mantenimiento del volumen celular, la excitabilidad eléctrica y el equilibrio ácido-base. La desregulación de los canales de cloruro está relacionada con enfermedades como la fibrosis quística, la epilepsia y los trastornos renales. En CymitQuimica, ofrecemos una variedad de moduladores de canales de cloruro para apoyar su investigación en el transporte de iones, la homeostasis celular y los mecanismos de enfermedades.
Se han encontrado 49 productos de "Canal de cloruro"
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Halothane
CAS:<p>Halothane (Anestan) 可以减弱内皮依赖性舒张作用。</p>Fórmula:C2HBrClF3Pureza:98.50% - >99.99%Forma y color:Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustiblePeso molecular:197.38Flufenamic acid
CAS:<p>Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.</p>Fórmula:C14H10F3NO2Pureza:98.68%Forma y color:White To Light Yellow Crystalline PowderPeso molecular:281.23DCPIB
CAS:<p>DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM</p>Fórmula:C22H28Cl2O4Pureza:99.79% - 99.87%Forma y color:SolidPeso molecular:427.36Eact
CAS:<p>Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.</p>Fórmula:C22H24N2O5SPureza:98.14%Forma y color:SolidPeso molecular:428.5Meticrane
CAS:<p>Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.</p>Fórmula:C10H13NO4S2Pureza:99.16%Forma y color:SolidPeso molecular:275.34T16Ainh-A01
CAS:<p>T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.</p>Fórmula:C19H20N4O3S2Pureza:97.18% - 98.15%Forma y color:SolidPeso molecular:416.52Niflumic acid
CAS:<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>Fórmula:C13H9F3N2O2Pureza:99.47%Forma y color:SolidPeso molecular:282.22NS1652
CAS:<p>NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.</p>Fórmula:C15H11F3N2O3Pureza:99.62%Forma y color:SolidPeso molecular:324.25Endovion
CAS:<p>Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.</p>Fórmula:C16H9BrF6N6OPureza:98.51%Forma y color:SolidPeso molecular:495.18Afoxolaner
CAS:<p>Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.</p>Fórmula:C26H17ClF9N3O3Pureza:99.1% - 99.38%Forma y color:SolidPeso molecular:625.87GaTx2
CAS:<p>High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.</p>Fórmula:C125H199N39O47S6Pureza:98%Forma y color:SolidPeso molecular:3192.54Chlorotoxin
CAS:<p>Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.</p>Fórmula:C158H249N53O47S11Pureza:98%Forma y color:SolidPeso molecular:3995.71Chlorotoxin TFA
<p>Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.</p>Fórmula:C160H250F3N53O49S11Forma y color:SolidPeso molecular:4109.74ANO1-IN-4
CAS:<p>ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.</p>Fórmula:C19H19BrF2N2O2SForma y color:SolidPeso molecular:457.33Chlorotoxin(linear)
<p>Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.</p>Fórmula:C158H256N52O48S11Pureza:98%Forma y color:SolidPeso molecular:4004.76Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Forma y color:Odour SolidLubiprostone hemiketal
CAS:<p>Lubiprostone (hemiketal) (RU-0211 (hemiketal)), a selective activator of the chloride channel 2 (CLCN2), facilitates the treatment of chronic idiopathic constipation and opioid-induced constipation. It functions by enhancing CLCN2 channel activity, which boosts chloride ion secretion in the intestines, subsequently increasing fluid secretion and improving intestinal peristalsis. Additionally, Lubiprostone (hemiketal) may be utilized in research related to chronic constipation and cancer.</p>Fórmula:C20H32F2O5Forma y color:SolidPeso molecular:390.46NPPB
CAS:<p>NPPB is a chloride channel blocker with IC50 of 80 nM .</p>Fórmula:C16H16N2O4Pureza:99.95%Forma y color:Light Yellow To Yellow SolidPeso molecular:300.31MONNA
CAS:<p>MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.</p>Fórmula:C18H14N2O5Pureza:98.29%Forma y color:SolidPeso molecular:338.31Guanidinoethyl sulfonate
CAS:<p>Guanidinoethyl sulfonate (Taurocyamine) is a competitive glycine receptor antagonist.</p>Fórmula:C3H9N3O3SPureza:99.43% - 99.47%Forma y color:SolidPeso molecular:167.19Adjudin
CAS:<p>Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.</p>Fórmula:C15H12Cl2N4OPureza:96.51% - ≥95%Forma y color:SolidPeso molecular:335.19Anthracene-9-carboxylic acid
CAS:<p>Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI.</p>Fórmula:C15H10O2Pureza:99.05%Forma y color:Yellow Cystalline PowderPeso molecular:222.24Phenyl benzoate
CAS:<p>Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid.It is an important organic synthesis intermediate.</p>Fórmula:C13H10O2Pureza:99.63%Forma y color:White Crystalline PowderPeso molecular:198.22Org 25543
CAS:<p>Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.</p>Fórmula:C24H32N2O4Pureza:99.13%Forma y color:SolidPeso molecular:412.52CaCCinh-A01
CAS:<p>CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).</p>Fórmula:C18H21NO4SPureza:99.36% - >99.99%Forma y color:SolidPeso molecular:347.43Selamectin
CAS:<p>Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in</p>Fórmula:C43H63NO11Pureza:99.84%Forma y color:SolidPeso molecular:769.96Irisolidone
CAS:<p>Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.</p>Fórmula:C17H14O6Pureza:99.41% - 99.87%Forma y color:SolidPeso molecular:314.29Fenamic acid
CAS:<p>Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats.</p>Fórmula:C13H11NO2Pureza:99.6%Forma y color:White To Off-White Crystalline PowderPeso molecular:213.2319Lubiprostone
CAS:<p>Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.</p>Fórmula:C20H32F2O5Pureza:97.31% - 98.54%Forma y color:White Odorless Crystals Or Crystalline PowderPeso molecular:390.46Talniflumate
CAS:<p>Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell</p>Fórmula:C21H13F3N2O4Pureza:98% - 99.81%Forma y color:White To Pale Yellow Crystalline PowderPeso molecular:414.33NS5818
CAS:<p>NS5818 inhibits ClC.</p>Fórmula:C23H19Cl2N7O2Pureza:98%Forma y color:SolidPeso molecular:496.35Alilusem
CAS:<p>Alilusem is a new diuretic that is beneficial to the clinical treatment of hypertension.</p>Fórmula:C17H15ClKN2O5SForma y color:SolidPeso molecular:433.92H100
CAS:<p>H100 inhibits Cl- transport, mildly affects NaK2Cl cotransporter and Band 3 anion exchanger, not KCl cotransporter.</p>Fórmula:C18H16N2O6SPureza:98%Forma y color:SolidPeso molecular:388.4ANO1-IN-2
CAS:<p>ANO1-IN-2: potent ANO1 blocker (IC50: 1.75 μM), less effective on ANO2 (IC50: 7.43 μM), inhibits glioblastoma cell growth.</p>Fórmula:C16H14ClN3O2S2Forma y color:SolidPeso molecular:379.88BTG-1640
CAS:<p>BTG-1640 is used potentially for the treatment of anxiety and panic disorder.</p>Fórmula:C15H19NO2Forma y color:SolidPeso molecular:245.32Bts 39542
CAS:<p>Bts 39542 is a diuretic that plays a major role in the Henle circulation and increases renal blood flow without affecting glomerular filtration rate.</p>Fórmula:C16H11ClN4O3SForma y color:SolidPeso molecular:374.8IAA-94
CAS:<p>IAA-94 is an inhibitor of chloride channels, it binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM.</p>Fórmula:C17H18Cl2O4Forma y color:SolidPeso molecular:357.23Hydroflumethiazide
CAS:<p>Hydroflumethiazide is a thiazide diuretic. It has also shown the activity of anti-hypertensive.</p>Fórmula:C8H8F3N3O4S2Forma y color:Crystals SolidPeso molecular:331.29Losigamone
CAS:<p>Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.</p>Fórmula:C12H11ClO4Pureza:99.98%Forma y color:SolidPeso molecular:254.67R(+)-IAA-94
CAS:<p>R(+)-IAA-94 (Methylindazone) blocks epithelial chloride channels; inhibits Nef-sdAb19 binding.</p>Fórmula:C17H18Cl2O4Pureza:98.95% - 99.17%Forma y color:SolidPeso molecular:357.23Stepronin
CAS:<p>Stepronin (TTPG) shows expectorant activities and inhibits airway secretion.</p>Fórmula:C10H11NO4S2Pureza:99.59%Forma y color:White Or Off White CrystallinePeso molecular:273.33ANO1-IN-1
CAS:<p>ANO1-IN-1 blocks ANO1/2 channels (IC50: 2.56/15.43 μM) and hinders glioma cell growth.</p>Fórmula:C18H28N2O2SPureza:99.66%Forma y color:SolidPeso molecular:336.49Ani9
CAS:<p>Ani9 selectively blocks ANO1/TMEM16A with a 77 nM IC50, useful for ANO1 research and treating cancer, hypertension, pain, diarrhea, asthma.</p>Fórmula:C17H17ClN2O3Pureza:99.73%Forma y color:SolidPeso molecular:332.78ARN 11391
CAS:<p>ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ion</p>Fórmula:C22H29N3O3Forma y color:SolidPeso molecular:383.49OADS
CAS:<p>OADS is an inhibitor of ClC-ec1 with low micromolar affinity. OADS has no specific effect on a CLC channel (ClC-1).</p>Fórmula:C30H42N2O8S2Forma y color:SolidPeso molecular:622.79S9-A13
CAS:<p>S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.</p>Fórmula:C20H18ClN3O2SForma y color:SolidPeso molecular:399.89NMD670
CAS:<p>NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].</p>Fórmula:C12H10BrNO4Forma y color:SolidPeso molecular:312.12DFBTA
<p>DFBTA inhibits ANO1 with IC50 of 24 nM, effectively treating inflammatory pain orally.</p>Fórmula:C18H10ClF2NO3SForma y color:SolidPeso molecular:393.79T16A(inh)-C01
CAS:<p>T16A(inh)-C01 is the Ca(2+)-activated Cl(-) Channel, Ano1 class C inhibitor.</p>Fórmula:C18H16O5Pureza:98%Forma y color:SolidPeso molecular:312.32
