Receptor CGRP
Los receptores de CGRP están involucrados en la transmisión del dolor y la regulación del flujo sanguíneo. El CGRP es un neuropéptido que desempeña un papel crucial en la fisiopatología de la migraña al dilatar los vasos sanguíneos y modular las vías de señalización del dolor. Dirigirse a los receptores de CGRP se ha convertido en un enfoque prometedor en el desarrollo de terapias para la migraña. En CymitQuimica, ofrecemos una gama de moduladores de receptores de CGRP para apoyar su investigación en el manejo del dolor, neurobiología y salud vascular.
Se han encontrado 55 productos de "Receptor CGRP"
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Erenumab
CAS:Erenumab: human antibody blocking CGRP receptors to prevent migraines.Pureza:99.43% (SEC-HPLC) - > 95%Forma y color:LiquidPeso molecular:146.2 kDaPHM-27 (human) acetate
PHM-27 (human) acetate is the endogenous peptide product of prepro-VIP (human), an agonist of the calcitonin receptor (EC 50 = 11 nM). enhanced insulin secretion.
Fórmula:C137H215F3N34O42SPureza:99.20%Forma y color:SoildPeso molecular:3099.44Vazegepant
CAS:Vazegepant is an intranasal CGRP receptor antagonist utilized for conducting acute migraine research.Fórmula:C36H46N8O3Pureza:98.61% - 99.98%Forma y color:SolidPeso molecular:638.80Ref: TM-T38734
1mg90,00€5mg215,00€1mL*10mM (DMSO)289,00€10mg318,00€25mg537,00€50mg767,00€100mg1.054,00€β-CGRP, human
CAS:β-CGRP, human ,a 37-amino acid peptide,is the beta form of Calcitonin-gene-related peptide (β-CGRP), involved extensively in regulation of the cardiovascularFórmula:C162H267N51O48S3Pureza:98%Forma y color:SolidPeso molecular:3793.41(3R,5R,6S)-Atogepant
(3R,5R,6S)-Atogepant (MK-8031) is a CGRP antagonist enantiomer used in migraine research.Fórmula:C29H23F6N5O3Forma y color:SolidPeso molecular:603.52PHM-27 (human)
CAS:Human-derived peptide, VIP/PHM 27 analog, boosts insulin by targeting calcitonin receptor with an EC50 of 11 nM.Fórmula:C135H214N34O40SPureza:98%Forma y color:SolidPeso molecular:2985.44Adrenomedullin (AM) (22-52), human TFA
Adrenomedullin (AM) human (22-52) is a truncated NH2 TFA-modified adrenal medullary receptor antagonist.Fórmula:C161H253N46F3O50Pureza:98%Forma y color:SolidPeso molecular:3690.06Calcitonin Gene Related Peptide (CGRP) II, rat
CAS:CGRP II is a potent vasodilator that boosts pancreatic enzyme levels by activating β-cell receptors.Fórmula:C163H267N51O50S2Pureza:98%Forma y color:SolidPeso molecular:3805.31Adrenomedullin (11-50), rat
CAS:Adrenomedullin 11-50 rat is a peptide, stimulates CGRP1 receptor for vasodilation, used in bone growth research.Fórmula:C194H304N58O59S4Pureza:98%Forma y color:SolidPeso molecular:4521.17HTL22562
CAS:HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine.Fórmula:C40H49N11O5Forma y color:SolidPeso molecular:763.904α-CGRP(human)
CAS:Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.Fórmula:C163H267N51O49S2Pureza:98%Forma y color:SolidPeso molecular:3789.33Adrenomedullin (16-31), human
CAS:Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM).Fórmula:C82H129N25O21S2Pureza:98%Forma y color:SolidPeso molecular:1865.19α-CGRP(human) TFA
α-CGRP(human) TFA is a 37-amino acid regulatory neuropeptide that is extensively located within the central and peripheral nervous system, functioning as aFórmula:C165H268F3N51O51S2Forma y color:SolidPeso molecular:3903.33Adrenomedullin (16-31), human TFA
Human adrenomedullin (16-31) TFA, fragment 16-31, binds CGRP1 receptor, raises rat blood pressure, not cats’.Fórmula:C84H130F3N25O23S2Forma y color:SolidPeso molecular:1979.21Adrenotensin (human)
CAS:Adrenotensin: human 153-185 fragment of Adrenomedullin precursor, a 52-amino acid peptide in CGRP hormone family.Fórmula:C143H224N42O43Forma y color:SolidPeso molecular:3219.56Calcitonin Gene Related Peptide (CGRP) II, rat TFA
Rat CGRP II TFA: potent vasodilator and CGRP receptor activator for cardiovascular research.Fórmula:C165H268F3N51O52S2Forma y color:SolidPeso molecular:3919.33Olcegepant hydrochloride
CAS:Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a selective calcitonin gene-related peptide 1 (CGRP1) receptor antagonist.Fórmula:C38H48Br2ClN9O5Pureza:99.69%Forma y color:SolidPeso molecular:906.11CRSP-1
CAS:Central CT receptor agonist, 350x stronger than CT, no CGRP or adrenomedullin action, inhibits osteoclasts, affects rat feeding, body temp, and calcium.Fórmula:C175H294N54O49S5Pureza:98%Forma y color:SolidPeso molecular:4098.88Cagrilintide acetate
.Cagrilintide is a long-acting amylin analog,treat diabetes and obesity by reducing appetite through activation of the AMY3R and calcitonin receptor.Fórmula:C196H316N54O61S2Pureza:99.88%Forma y color:SolidPeso molecular:4469.06β-CGRP (mouse)
β-CGRP (mouse), a calcitonin gene-related peptide, induces vasodilation and is applicable in research areas including cardiovascular, pro-inflammatory, migraine, and metabolic studies.Fórmula:C165H265N49O55S2Forma y color:SolidPeso molecular:3879.29CGRP 8-37 (rat)
CAS:CGRP 8-37 (rat) is a CGRP receptor antagonist, a CGRP fragment with potential anti-injury effects that induces arterial relaxation.Fórmula:C138H224N42O41Pureza:99.28%Forma y color:SolidPeso molecular:3127.51Adrenomedullin (AM) (22-52), human acetate
Adrenomedullin (AM) (22-52), human acetate is an antagonist of calcitonin generelated peptide receptor in the hindlimb vascular bed of the cat and anFórmula:C161H256N46O50Pureza:99.42%Forma y color:SolidPeso molecular:3636.09α-CGRP (mouse, rat) TFA
α-CGRP (mouse, rat) TFA, a neuropeptide belonging to the calcitonin gene-related peptide (CGRP) family, is predominantly located at neuromuscular junctions andFórmula:C162H262N50O52S2·C2HF3O2Pureza:98%Forma y color:SolidGalcanezumab
CAS:Galcanezumab: humanized IgG4 antibody that targets CGRP for migraine and cluster headache prevention/treatment.Pureza:> 95%Forma y color:LiquidPeso molecular:144.08 kDaUbrogepant-d5
Ubrogepant-d5 (MK-1602-d5) is the deuterium-labeled version of Ubrogepant. It is an orally active and selective antagonist of the calcitonin gene-related peptide receptor (CGRP). Ubrogepant exhibits high affinity for CGRP receptors in humans and rhesus monkeys, effectively blocking the cAMP response induced by α-CGRP stimulation. This compound is utilized in studies focused on acute migraine.Forma y color:Odour Solidα-CGRP (mouse, rat) (TFA)
α-CGRP (mouse, rat) TFA is a neuropeptide (calcitonin gene-related peptide) predominantly found at neuromuscular junctions and acts as a potent vasodilator. This compound is useful in research concerning cardiovascular, pro-inflammatory, migraine, and metabolic processes.Forma y color:Odour SolidCGRP antagonist 6
CGRP Antagonist 6 (Compound 23) is a potent CGRP receptor antagonist (Ki: 0.84 nM). It is utilized in the study of migraines.Forma y color:Odour SolidAdrenomedullin (1-50), rat
CAS:Rat adrenomedullin (1-50) is a 50-AA peptide; induces arterial vasodilation by activating CGRP1 receptors.Fórmula:C248H381N77O75S5Pureza:98%Forma y color:SolidPeso molecular:5729.5Adrenomedullin (AM) (22-52), human
CAS:Adrenomedullin (ADM) is a 52-aa hypotensive peptide. Adrenomedullin (ADM) has structural similarity with amylin.Fórmula:C159H252N46O48Pureza:98%Forma y color:SolidPeso molecular:3576.04HCGRP-(8-37)
CAS:Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonistFórmula:C139H230N44O38Pureza:98%Forma y color:SolidPeso molecular:3125.59Calcitonin (human)
CAS:Endogenous calcitonin receptor agonist. Lowers systemic blood calcium levels and inhibits bone resorption.Fórmula:C151H226N40O45S3Pureza:98%Forma y color:White Lyophilized PowderPeso molecular:3417.87α-CGRP, rat
CAS:Endogenous neuropeptide, potent vasodilatorFórmula:C162H262N50O52S2Pureza:98%Forma y color:SolidPeso molecular:3806.25Telcagepant
CAS:Telcagepant (MK-0974) is an oral calcitonin gene-related peptide receptor (CGRP) antagonist that blocks CGRP receptors, migraines and for pain relief.Fórmula:C26H27F5N6O3Pureza:98.98% - 98.98%Forma y color:SolidPeso molecular:566.52SUN B8155
CAS:SUN B8155 is a CT receptor agonist that induces cAMP formation in cells expressing recombinant human CT receptor.Fórmula:C14H15N3O3Pureza:99.38% - 99.99%Forma y color:SolidPeso molecular:273.29Calcitonin (salmon)
CAS:Calcitonin (salmon), a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.Fórmula:C145H240N44O48S2Pureza:99.41% - 99.80%Forma y color:PowderPeso molecular:3431.85Olcegepant
CAS:Olcegepant (BIBN-4096) is an effective and selective non-peptide calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (IC50 of 0.03 nM and Ki of 14.4Fórmula:C38H47Br2N9O5Pureza:96.08% - 97.24%Forma y color:SolidPeso molecular:869.65Vazegepant hydrochloride
CAS:Vazegepant hydrochloride (Vazegepant HCl) is the first intranasal gepant for the acute treatment of migraine and has announced a positive phase II/III study.Fórmula:C36H47ClN8O3Pureza:98.93%Forma y color:SolidPeso molecular:675.3Ref: TM-T8682
1mg102,00€5mg215,00€1mL*10mM (DMSO)313,00€10mg316,00€25mg535,00€50mg763,00€100mg1.054,00€Calcitonin(salmon) Acetate(47931-85-1(free base))
Calcitonin(salmon)Acetate(47931-85-1(free base))(Salmon calcitonin) , a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5Fórmula:C145H240N44O48S2Pureza:99.29%Forma y color:SolidPeso molecular:3431.85BCTC
CAS:BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)Fórmula:C20H25ClN4OPureza:99.21%Forma y color:SolidPeso molecular:372.89HCGRP-(8-37) acetate
HCGRP-(8-37) acetate is a human calcitonin gene-related peptide (hCGRP) fragment acetate and also an antagonist of CGRP receptor.Fórmula:C141H234N44O40Pureza:99.29%Forma y color:SolidPeso molecular:3185.64β-CGRP, human acetate
β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptorFórmula:C164H271N51O50S3Pureza:99.35%Forma y color:SolidPeso molecular:3853.46Rimegepant
CAS:View and buy Rimegepant from TargetMol.BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.Cited in 1 publications.Fórmula:C28H28F2N6O3Pureza:99.1% - 99.99%Forma y color:SolidPeso molecular:534.56Atogepant
CAS:Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine.Fórmula:C29H23F6N5O3Pureza:99.66%Forma y color:SolidPeso molecular:603.52Ref: TM-T26682
1mg147,00€5mg250,00€10mg313,00€1mL*10mM (DMSO)334,00€25mg620,00€50mg1.108,00€100mg1.611,00€200mg2.178,00€Fremanezumab
CAS:Fremanezumab (TEV-48125) is a humanised monoclonal antibody targeting CGRP, capable of neutralising human, mouse and rat CGRP, migraine.Pureza:95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.49 kDaEptinezumab
CAS:Eptinezumab is a humanised monoclonal antibody targeting CGRP (calcitonin gene-related peptide), which prevents CGRP binding to its receptor, migraine.
Pureza:95% - 95%Forma y color:LiquidCGRP antagonist 1
CAS:CGRP antagonist 1 is a potent CGRP receptor antagonist with Ki values of 35 nM and IC50 values of 57 nM, respectively.CGRP antagonist 1 can be used for theFórmula:C29H26N4O4Pureza:99.55%Forma y color:SolidPeso molecular:494.54Ubrogepant
CAS:Ubrogepant (MK-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies.Fórmula:C29H26F3N5O3Pureza:99.452% - 99.78%Forma y color:SolidPeso molecular:549.54Ref: TM-T17194
1mg144,00€5mg358,00€1mL*10mM (DMSO)432,00€10mg565,00€25mg880,00€50mg1.161,00€100mg1.594,00€MK-8825
CAS:MK-8825 is a CGRP receptor antagonist.Fórmula:C31H30F2N6O3Forma y color:SolidPeso molecular:572.61MK-3207
CAS:MK-3207 is a potent, oral CGRP receptor antagonist with high selectivity for human and monkey receptors, inhibiting blood flow in vivo.Fórmula:C31H29F2N5O3Forma y color:SolidPeso molecular:557.59CGRP antagonist 7
CAS:CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki value of 0.029 nM. It effectively inhibits CGRP receptor-mediated cyclic adenosine monophosphate (cAMP) production, with an IC50 value of 1.5 nM. This compound is useful in migraine research.Fórmula:C30H32FN5O3Forma y color:SolidPeso molecular:529.61DNA crosslinker 6
CAS:DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.Fórmula:C19H21N7OForma y color:SolidPeso molecular:363.42Rimegepant sulfate hydrate
CAS:Rimegepant (BMS-927711/BHV-3000): oral CGRP blocker for migraines, effective without vasoconstriction, beats placebo, well-tolerated.Fórmula:C56H64F4N12O13SForma y color:SolidPeso molecular:1221.2526MK-3207 Hydrochloride
CAS:MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.Fórmula:C31H30ClF2N5O3Pureza:98.19%Forma y color:SolidPeso molecular:594.05BI-44370
CAS:BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.Fórmula:C35H47N5O6Forma y color:SolidPeso molecular:633.78
