P-gp

Encequidar mesylate is a competitive P-glycoprotein inhibitor.

Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an …

Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It …

Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act …

1-piperoylpiperidine, (E,E)-, a alkaloid, has been used in trials studying the treatment of multiple myeloma …

1-Monopalmitin has dielectric properties. 1-Monopalmitin inhibits the P-glycoprotein activity in intestinal Caco-2 cells.

Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type …

Verapamil hydrochloride is a calcium channel blocker that is a class IV anti-arrhythmia agent.

Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by …

Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.

Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor …

Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of …

Cnidilin has high BBB permeability and has pharmacokinetic potentials for the treatment of central nervous …

(20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.

Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.

YS-370 is an orally active inhibitor of P-gp and shows moderate inhibition against CYP3A4. YS-370 …

Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 …

ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lymphoma cells.

Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in …

Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and …

3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adjuvant …

(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated …

Pepluanin A, shows a very high activity for a jatrophane diterpene, outperforming cyclosporin A by …

Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and …

Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and …

Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.

1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity …

P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 …

Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR …

Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat …

Standard reference

Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.

AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG …

Taxuspine X may have p-glycoprotein inhibitory activity.

Verapamil is a calcium channel blocker and an orally active and effective inhibitor of P-gp. …

1. Evodine has antinociceptive activity.

2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton …

Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.

Chonglou saponin VII shows inhibitory effects on cell proliferation.

Tariquidar(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug …

Polyoxyethylene stearate is an agent of non-ionic emulsifying.

Elacridar (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor.

Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between …

Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated …

1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an …

1. Euphorbia factor L1 can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. …

Convallatoxin is a natural product.

(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.

Pristinamycin IA is a substrate for the P-glycoprotein and a cyclo-peptidic macrolactone antibiotic.

Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it …

Muscone is an organic compound that is the primary contributor to the odor of musk.

Zosuquidar (LY335979) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. …

Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.

Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at …

1. Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.

HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability …

Encequidar is a potent and selective P-glycoprotein inhibitor.

7β-Hydroxylathyrol is a diterpenoid extract from the seed oil of Caper Spurge and displays P-gp …

Bacoside A3 is one of the components of Bacopa monnieri (L.) Wettst. bacoside A with …

Trifluoperazine is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.

gamma-Tocotrienol is one of the four types of tocotrienol, a type of vitamin E. Itl …

Alisol F 24-acetate is a natural product isolated from Alisma plantago-aquatica Linn[1]. Alisol F 24 …

Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard …

Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum …

Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for …

Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. …

1. Chrysosplenetin is a metabolic inhibitor of artemisinin.

Taxol C can reduce interaction with the P-glycoprotein transporter that may allow for increased permeation …

Voacamine is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also …

Dofequidar (MS-209) is a quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.