P-gp
La P-glicoproteína es una bomba de eflujo dependiente de ATP que transporta una amplia variedad de sustratos, incluidos medicamentos, toxinas y lípidos, fuera de las células. Desempeña un papel crucial en la resistencia a los medicamentos, particularmente en el cáncer, al reducir la concentración intracelular de agentes quimioterapéuticos. La P-gp también está involucrada en la barrera hematoencefálica, influyendo en la exposición del sistema nervioso central a varios compuestos. En CymitQuimica, ofrecemos una gama de moduladores de la P-gp para apoyar su investigación en resistencia a los medicamentos, farmacocinética y desarrollo terapéutico.
Se han encontrado 55 productos de "P-gp"
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Norverapamil hydrochloride
CAS:Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Fórmula:C26H37ClN2O4Pureza:99.47%Forma y color:SolidPeso molecular:477.04Ref: TM-T16339
1mg34,00€5mg105,00€10mg177,00€25mg299,00€50mg447,00€100mg602,00€200mg842,00€1mL*10mM (DMSO)110,00€Zamicastat
CAS:Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Fórmula:C21H21F2N3OSPureza:99.58%Forma y color:SolidPeso molecular:401.47Ref: TM-T13383
1mg92,00€5mg193,00€10mg293,00€25mg528,00€50mg795,00€100mg1.153,00€1mL*10mM (DMSO)210,00€Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Fórmula:C23H27FN4O2Pureza:99.73%Forma y color:Crystalline SolidPeso molecular:410.48Ref: TM-T0351
10mg48,00€25mg56,00€50mg88,00€100mg122,00€200mg192,00€500mg323,00€1mL*10mM (DMSO)50,00€Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Fórmula:C23H28ClN3O5SPureza:99.05% - 99.75%Forma y color:SolidPeso molecular:494.00Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Fórmula:C21H26Cl2F3N3SPureza:99.57% - 99.96%Forma y color:Cream Fine PowderPeso molecular:480.43Piperine
CAS:Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
Fórmula:C17H19NO3Pureza:98.41% - 98.51%Forma y color:SolidPeso molecular:285.34Dofequidar fumarate
CAS:Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the
Fórmula:C34H35N3O7Pureza:99.93%Forma y color:SolidPeso molecular:597.66Ref: TM-T11071
1mg39,00€2mg50,00€5mg85,00€10mg125,00€25mg245,00€50mg472,00€100mg687,00€500mg1.444,00€Encequidar mesylate
CAS:Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
Fórmula:C39H40N6O10SPureza:99.84%Forma y color:SolidPeso molecular:784.83Atazanavir sulfate
CAS:Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Fórmula:C38H52N6O7·H2SO4Pureza:99.31% - 99.40%Forma y color:SolidPeso molecular:802.93Ref: TM-T0100
5mg44,00€10mg58,00€25mg90,00€50mg114,00€100mg170,00€200mg250,00€500mg425,00€1mL*10mM (DMSO)50,00€(20S)-Protopanaxadiol
CAS:(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFórmula:C30H52O3Pureza:97.07% - 98.91%Forma y color:SolidPeso molecular:460.73Atazanavir
CAS:Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Fórmula:C38H52N6O7Pureza:98% - 99.95%Forma y color:Crystalline SolidPeso molecular:704.86Verapamil hydrochloride
CAS:Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Fórmula:C27H39ClN2O4Pureza:98.7% - 99.98%Forma y color:White To Off-White PowderPeso molecular:491.06P-gp inhibitor 14
CAS:Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].Fórmula:C37H38N2O8Forma y color:SolidPeso molecular:638.71P-gp modulator-5
P-gp Modulator-5 (compound 25) serves as a modulator of P-gp, effectively inhibiting the proliferation of multidrug-resistant (MDR) tumors. This compound suppresses the function of drug efflux pumps in MDR cells, which results in significant accumulation of ROS and modifications in cell cycle profiles.Fórmula:C19H16N2O5Forma y color:SolidPeso molecular:352.34Evodine
CAS:1. Evodine has antinociceptive activity.Fórmula:C18H19NO5Pureza:98%Forma y color:SolidPeso molecular:329.35CPI1
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.Fórmula:C111H131N23O30SForma y color:SolidPeso molecular:2299.43FM04
CAS:FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.Fórmula:C26H25NO4Pureza:99.87%Forma y color:SolidPeso molecular:415.48P-gb-IN-1
CAS:P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Fórmula:C30H28N2O6Pureza:99.85%Forma y color:SoildPeso molecular:512.55Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Fórmula:C40H58N4O18S2Pureza:98.13%Forma y color:SolidPeso molecular:947.04YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Fórmula:C37H35BrN4O3Pureza:98.055%Forma y color:SolidPeso molecular:663.6Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Fórmula:C39H37F3N4O5Pureza:99.85%Forma y color:SoildPeso molecular:698.73WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Fórmula:C16H13N5OS2Forma y color:SolidPeso molecular:355.44Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Fórmula:C63H111N11O12Pureza:95% - >99.99%Forma y color:SolidPeso molecular:1214.62P-gp inhibitor 25
CAS:P-gp Inhibitor 25 (compound 16c) is a P-gp inhibitor that enhances the oral absorption of paclitaxel. It is utilized in cancer research to improve treatment efficacy.Fórmula:C41H36N4O8Peso molecular:712.75Solamargine
CAS:Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Fórmula:C45H73NO15Pureza:99.17% - 99.96%Forma y color:SolidPeso molecular:868.06Ref: TM-T4034
1mg56,00€2mg78,00€5mg109,00€10mg165,00€25mg289,00€50mg434,00€100mg655,00€200mg883,00€1mL*10mM (DMSO)158,00€Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Fórmula:C11H10N4S3Pureza:99.15%Forma y color:SolidPeso molecular:294.42Ref: TM-T8596
1mg43,00€5mg88,00€10mg119,00€25mg250,00€50mg389,00€100mg550,00€200mg785,00€1mL*10mM (DMSO)87,00€Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
Fórmula:C51H82O21Pureza:99.51% - 99.63%Forma y color:SolidPeso molecular:1031.18Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Fórmula:C20H40O3Pureza:n~9-10Forma y color:Light Amber SemisolidPeso molecular:328.29775Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Fórmula:C20H20O7Pureza:99.98% - ≥95%Forma y color:SolidPeso molecular:372.37Ref: TM-T2S0223
1mg63,00€5mg135,00€10mg195,00€25mg326,00€50mg485,00€100mg700,00€1mL*10mM (DMSO)165,00€Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.
Fórmula:C43H52N4O5Pureza:98.54% - 99.82%Forma y color:SolidPeso molecular:704.9Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Fórmula:C38H38N4O6Pureza:98.07% - 99.45%Forma y color:SolidPeso molecular:646.73Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFórmula:C43H63NO11Pureza:99.84%Forma y color:SolidPeso molecular:769.96Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Fórmula:C26H30O11Pureza:97.91%Forma y color:SolidPeso molecular:518.51Ref: TM-TN4761
1mg155,00€5mg304,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€1mL*10mM (DMSO)389,00€Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Fórmula:C16H24NO5Pureza:98% - 99.68%Forma y color:White Or Light-Tan SolidPeso molecular:310.37Convallatoxin
CAS:Convallatoxin is a natural product.Fórmula:C29H42O10Pureza:99.27% - 99.53%Forma y color:Prisms From Methanol + Ether SolidPeso molecular:550.64Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Fórmula:C32H31F2N3O2·3HClPureza:99.49% - >99.99%Forma y color:SolidPeso molecular:636.99Hypophyllanthin
CAS:Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Fórmula:C24H30O7Pureza:98.39%Forma y color:SolidPeso molecular:430.49Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Fórmula:C32H31F2N3O2Pureza:99.99%Forma y color:SolidPeso molecular:527.6Ref: TM-T6018L
1mg73,00€5mg152,00€10mg220,00€25mg358,00€50mg537,00€100mg782,00€200mg1.071,00€1mL*10mM (DMSO)170,00€HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Fórmula:C39H42N6O11SPureza:99.37%Forma y color:SolidPeso molecular:802.85Ref: TM-T9173
1mg65,00€2mg94,00€5mg119,00€10mg185,00€25mg309,00€50mg442,00€100mg643,00€200mg835,00€500mg1.251,00€1mL*10mM (DMSO)177,00€Encequidar
CAS:Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Fórmula:C38H36N6O7Pureza:99.93%Forma y color:SolidPeso molecular:688.73Ref: TM-T8426
1mg46,00€2mg62,00€5mg90,00€10mg137,00€25mg234,00€50mg360,00€100mg528,00€1mL*10mM (DMSO)127,00€Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Fórmula:C21H24F3N3SPureza:98.3% - 99.46%Forma y color:White To Yellowish Crystalline PowderPeso molecular:407.5γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Fórmula:C28H42O2Pureza:97.27% - 98.13%Forma y color:SolidPeso molecular:410.63Ref: TM-T19768
1mg44,00€2mg58,00€5mg96,00€10mg137,00€25mg224,00€50mg333,00€100mg489,00€200mg705,00€1mL*10mM (DMSO)92,00€Sinapine thiocyanate
CAS:Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Fórmula:C16H24NO5·CNSPureza:99.79% - ≥95%Forma y color:SolidPeso molecular:368.45Talinolol
CAS:(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Fórmula:C20H33N3O3Pureza:98.8%Forma y color:SolidPeso molecular:363.49Ref: TM-T21640
2mg34,00€5mg52,00€10mg92,00€25mg178,00€50mg313,00€100mg535,00€200mg775,00€1mL*10mM (DMSO)52,00€Elacridar
CAS:Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Fórmula:C34H33N3O5Pureza:98.12% - >99.99%Forma y color:SolidPeso molecular:563.64Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Fórmula:C19H18O8Pureza:97.43% - 98.4%Forma y color:SolidPeso molecular:374.34Ref: TM-TJS1159
1mg57,00€5mg120,00€10mg178,00€25mg329,00€50mg485,00€100mg692,00€500mg1.404,00€1mL*10mM (DMSO)215,00€HTT-D3
CAS:HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.
Fórmula:C23H25FN6Pureza:99.31%Forma y color:SolidPeso molecular:404.48Verapamil
CAS:Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Fórmula:C27H38N2O4Pureza:99.61% - 99.93%Forma y color:OilPeso molecular:454.6Ref: TM-T20656
10mg35,00€25mg51,00€50mg73,00€100mg96,00€200mg143,00€500mg230,00€1mL*10mM (DMSO)55,00€P-gp inhibitor 1
CAS:P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).Fórmula:C32H31N5O2Pureza:98.65%Forma y color:SolidPeso molecular:517.62Ref: TM-T12341
5mg50,00€10mg84,00€25mg150,00€50mg219,00€100mg304,00€200mg419,00€1mL*10mM (DMSO)58,00€P-gp inhibitor 17
CAS:P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].Fórmula:C36H49N3O3Forma y color:SolidPeso molecular:571.79
