P-gp
La P-glicoproteína es una bomba de eflujo dependiente de ATP que transporta una amplia variedad de sustratos, incluidos medicamentos, toxinas y lípidos, fuera de las células. Desempeña un papel crucial en la resistencia a los medicamentos, particularmente en el cáncer, al reducir la concentración intracelular de agentes quimioterapéuticos. La P-gp también está involucrada en la barrera hematoencefálica, influyendo en la exposición del sistema nervioso central a varios compuestos. En CymitQuimica, ofrecemos una gama de moduladores de la P-gp para apoyar su investigación en resistencia a los medicamentos, farmacocinética y desarrollo terapéutico.
Se han encontrado 53 productos de "P-gp"
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FM04
CAS:<p>FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.</p>Fórmula:C26H25NO4Pureza:99.77%Forma y color:SolidPeso molecular:415.48Solamargine
CAS:<p>Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.</p>Fórmula:C45H73NO15Pureza:99.17% - 99.96%Forma y color:SolidPeso molecular:868.06Ceefourin 1
CAS:<p>Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.</p>Fórmula:C11H10N4S3Pureza:99.15%Forma y color:SolidPeso molecular:294.42Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Fórmula:C51H82O21Pureza:99.51% - 99.63%Forma y color:SolidPeso molecular:1031.18Polyoxyethylene stearate
CAS:<p>Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.</p>Fórmula:C20H40O3Pureza:n~9-10Forma y color:Light Amber SemisolidPeso molecular:328.29775Isosinensetin
CAS:<p>1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.</p>Fórmula:C20H20O7Pureza:99.05% - ≥95%Forma y color:SolidPeso molecular:372.37Voacamine
CAS:<p>Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.</p>Fórmula:C43H52N4O5Pureza:98.54% - 99.82%Forma y color:SolidPeso molecular:704.9Tariquidar
CAS:<p>Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.</p>Fórmula:C38H38N4O6Pureza:98.07% - 99.45%Forma y color:SolidPeso molecular:646.73Selamectin
CAS:<p>Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in</p>Fórmula:C43H63NO11Pureza:99.84%Forma y color:SolidPeso molecular:769.96Phellamurin
CAS:<p>Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.</p>Fórmula:C26H30O11Pureza:97.91%Forma y color:SolidPeso molecular:518.51Sinapine
CAS:<p>Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.</p>Fórmula:C16H24NO5Pureza:98% - 99.68%Forma y color:White Or Light-Tan SolidPeso molecular:310.37Convallatoxin
CAS:<p>Convallatoxin is a natural product.</p>Fórmula:C29H42O10Pureza:99.27% - 99.53%Forma y color:Prisms From Methanol + Ether SolidPeso molecular:550.64Zosuquidar trihydrochloride
CAS:<p>Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.</p>Fórmula:C32H31F2N3O2·3HClPureza:99.49% - >99.99%Forma y color:SolidPeso molecular:636.99Hypophyllanthin
CAS:<p>Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.</p>Fórmula:C24H30O7Pureza:98.39%Forma y color:SolidPeso molecular:430.49Zosuquidar
CAS:<p>Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.</p>Fórmula:C32H31F2N3O2Forma y color:SolidPeso molecular:527.6HM-30181 mesylate monohydrate
CAS:<p>HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.</p>Fórmula:C39H42N6O11SPureza:99.37%Forma y color:SolidPeso molecular:802.85Encequidar
CAS:<p>Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.</p>Fórmula:C38H36N6O7Pureza:99.93%Forma y color:SolidPeso molecular:688.73Trifluoperazine
CAS:<p>Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.</p>Fórmula:C21H24F3N3SPureza:98.3% - 99.46%Forma y color:White To Yellowish Crystalline PowderPeso molecular:407.5γ-Tocotrienol
CAS:<p>γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.</p>Fórmula:C28H42O2Pureza:97.27% - 98.13%Forma y color:SolidPeso molecular:410.63Sinapine thiocyanate
CAS:<p>Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.</p>Fórmula:C16H24NO5·CNSPureza:99.79% - ≥95%Forma y color:SolidPeso molecular:368.45
