Transportador de monoamina
Los transportadores de monoaminas son un grupo de proteínas de membrana responsables de la recaptación de monoaminas—como la serotonina, dopamina y norepinefrina—desde la hendidura sináptica de regreso a las neuronas presinápticas. Este proceso es crucial para regular los niveles de neurotransmisores y mantener una neurotransmisión adecuada. La disfunción de los transportadores de monoaminas está asociada con varios trastornos psiquiátricos y neurológicos, como la depresión, la ansiedad y la enfermedad de Parkinson. En CymitQuimica, ofrecemos una gama de moduladores de transportadores de monoaminas para apoyar su investigación en neurobiología, salud mental y farmacología.
Se han encontrado 31 productos para "Transportador de monoamina".
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Nisoxetine hydrochloride
CAS:Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitorFórmula:C17H21NO2·HClPureza:99.21%Forma y color:White SolidPeso molecular:307.82VMAT2-IN-I HCl
CAS:VMAT2-IN-I HCl is an inhibitor of vesicular monoamine transporter-2. It also has 15- fold greater affinity than GZ- 793A.Fórmula:C25H32ClF4NO4Pureza:98%Forma y color:SolidPeso molecular:521.97Imipramine pamoate
CAS:Imipramine pamoate, a potent antidepressant [1] [2], is a chemical compound widely recognized for its efficacy in treating depressive disorders.Fórmula:C61H64N4O6Forma y color:SolidPeso molecular:949.18GZ-11608
CAS:GZ-11608, a selective and potent inhibitor of vesicular monoamine transporter-2 (VMAT2), presents a high affinity with a Ki value of 25 nM. It effectively reduces dopamine release induced by methamphetamine from isolated synaptic vesicles in brain dopaminergic neurons. GZ-11608 also demonstrates rapid penetration into the brain without exhibiting neurotoxicity, making it a valuable compound for researching methamphetamine use disorder [1].Fórmula:C19H25NOForma y color:SolidPeso molecular:283.41(2S,3S,11bR)-Dihydrotetrabenazine
CAS:(2S,3S,11bR)-Dihydrotetrabenazine ((2S,3S,11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. It suppresses the vesicular transport of monoamine neurotransmitters, such as dopamine and serotonin, leading to reduced release into the synaptic cleft. This compound holds potential for research in Huntington's disease and other hyperkinetic movement disorders.Fórmula:C19H29NO3Forma y color:SolidPeso molecular:319.44F3288-0031
CAS:F3288-0031 is an allosteric inhibitor of the norepinephrine transporter (NET), demonstrating a 73.5% inhibition rate at a concentration of 20 µM. It binds to NET, stabilizing its inward-open state, and shows preferential inhibitory activity against NET/SERT, with a pIC50 of 5.9. No off-target functional activity has been detected for F3288-0031. Furthermore, it exhibits significant antidepressant-like efficacy without interfering with motor functions. This compound is applicable in the study of depression and related neuropsychiatric disorders.Fórmula:C24H32N2O3Peso molecular:396.533-Bromoamphetamine hydrochloride
CAS:3-Bromoamphetamine hydrochloride is a para-substituted amphetamine that functions as a monoamine releaser.Fórmula:C9H13BrClNForma y color:SolidPeso molecular:250.563DLX48
CAS:DLX48 is a transporter inhibitor that binds to the active site of the LeuBAT (Δ13 mutant) transporter. It can traverse the blood-brain barrier and presents a low risk of drug interactions related to cytochrome P450. DLX48 is applicable in research on major depressive disorder.Fórmula:C18H20N2OSPeso molecular:312.43Valbenazine tosylate
CAS:Valbenazine tosylate, the tosylate salt of valbenazine, is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying noFórmula:C38H54N2O10S2Pureza:98%Forma y color:SolidPeso molecular:762.97Lafadofensine (D-(-)-Mandelic acid)
Lafadofensine D-(-)-Mandelic acid is a monoamines reuptake inhibitor with adequate effects when administered short-term.Fórmula:C32H32F2N2O6Forma y color:SolidPeso molecular:578.6(+)-Tetrabenazine
CAS:(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) is a reversible vesicular monoamine transporter 2 (VMAT-2) inhibitor, inhibits transport by VMAT2 with 10-foldFórmula:C19H27NO3Pureza:98.69%Forma y color:SolidPeso molecular:317.42
