Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Se han encontrado 202 productos de "Canal de sodio"
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Ancistrotecine B
<p>Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1].</p>Fórmula:C26H31NO4Pureza:98%Forma y color:SolidPeso molecular:421.53PF-06456384 trihydrochloride
CAS:<p>PF-06456384 trihydrochloride is a selective NaV1.7 inhibitor acting through protein-ligand binding. intravenous infusion and pain research.</p>Fórmula:C35H35Cl3F3N7O3S2Pureza:99.16%Forma y color:SolidPeso molecular:829.18Solpecainol
CAS:<p>solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases.</p>Fórmula:C18H23NO3Pureza:99.71%Forma y color:SoildPeso molecular:301.38Analgesic agent-2
<p>Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the human</p>Fórmula:C21H21ClF2N4O2Pureza:98%Forma y color:SolidPeso molecular:434.871-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS:<p>1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.</p>Fórmula:C6H8N2OPureza:99.92%Forma y color:SolidPeso molecular:124.14Nav1.7-IN-18
<p>Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).</p>Fórmula:C30H33Cl2F2NO4Forma y color:SolidPeso molecular:580.49Myomodulin
CAS:<p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>Fórmula:C36H67N11O8S2Pureza:98%Forma y color:SolidPeso molecular:846.12ASG-5ME
<p>ASG-5ME is a drug-antibody coupling targeting SLC44A4 that shows anti-tumor activity in xenograft models and may be used to study pancreatic and gastric cancer.</p>Pureza:98.1% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.5% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.5 kDaZandatrigine
CAS:<p>Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can be used in studies about nervous system pathologies of epilepsy</p>Fórmula:C22H25FN4O2S2Pureza:99.98%Forma y color:SolidPeso molecular:460.59Zoniporide hydrochloride
CAS:<p>Zoniporide hydrochloride: selective NHE-1 inhibitor, IC50 14 nM, >150x selectivity over other NHEs, inhibits platelet swelling (IC50 59 nM).</p>Fórmula:C17H17ClN6OPureza:99.68%Forma y color:SolidPeso molecular:356.81ETD001
CAS:<p>ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.</p>Fórmula:C41H57F6N9O16Forma y color:SolidPeso molecular:1045.935-Tridecanol
CAS:<p>5-Tridecanol blocks ion flux in sodium channels.</p>Fórmula:C13H28OPureza:97.87%Forma y color:SolidPeso molecular:200.36NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Fórmula:C23H20ClN3O3Forma y color:SolidPeso molecular:421.11932APETx2
CAS:<p>ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.</p>Fórmula:C196H280N54O61S6Pureza:98%Forma y color:SolidPeso molecular:4561.06Mambalgin 1
CAS:<p>ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.</p>Fórmula:C272H429N85O84S10Pureza:98%Forma y color:SolidPeso molecular:6554.51CL-424032
CAS:<p>CL-424032 is an inhibitor of sodium channels (sodium channel).</p>Fórmula:C12H7F3N4O2Forma y color:SolidPeso molecular:296.21ProTx II
CAS:<p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>Fórmula:C168H250N46O41S8Pureza:98%Forma y color:SolidPeso molecular:3826.59Indenebart
<p>Indenebart is a humanized IgG1λ2 monoclonal antibody targeting SNCA, with HumanIgG1lambda2, Isotype Control serving as the corresponding isotype control.</p>Forma y color:Odour LiquidIon Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Forma y color:Odour SolidHuwentoxin-IV
CAS:<p>Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.</p>Fórmula:C174H278N52O51S6Pureza:98%Forma y color:SolidPeso molecular:4106.79OD1
<p>Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.</p>Fórmula:C308H466N90O95S8Pureza:98%Forma y color:SolidPeso molecular:7206.1Phrixotoxin 3
CAS:<p>Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.</p>Fórmula:C176H269N51O48S6Pureza:98%Forma y color:SolidPeso molecular:4059.74Sodium Channel Targeted Library
<p>A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;</p>Forma y color:Odour SolidLifarizine FA
<p>Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.</p>Fórmula:C30H34N4O2Pureza:99.55%Forma y color:SolidPeso molecular:482.62Benzonatate (PEGn)
CAS:<p>Benzonatate (PEGn) is a unique non-narcotic cough suppressant featuring sodium channel blocking properties and anesthetic effects on respiratory tract stretch receptors.</p>Fórmula:(C2H4O)nC12H17NO2Forma y color:SolidGX 201
CAS:<p>GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.</p>Fórmula:C25H27ClF4N2O4SPureza:99.81%Forma y color:SolidPeso molecular:563Mepivacaine hydrochloride
CAS:<p>Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.</p>Fórmula:C15H22N2O·HClPureza:98.76% - 99.94%Forma y color:White Or Off White Crystalline PowderPeso molecular:282.81Amlenetug
<p>Amlenetug is a humanized IgG1κ antibody targeting SNCA, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Forma y color:Odour LiquidMexiletine-d6 hydrochloride
CAS:<p>Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.</p>Fórmula:C11H18ClNOPureza:98%Forma y color:SolidPeso molecular:221.76Triamterene D5
CAS:<p>Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic.</p>Fórmula:C12H11N7Pureza:98%Forma y color:SolidPeso molecular:258.29BI-9627
CAS:<p>BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) (EC50: 31 nM).</p>Fórmula:C16H19F3N4O2Pureza:99.77%Forma y color:SolidPeso molecular:356.34Poneratoxin acetate
<p>Poneratoxin acetate is a neurotoxic peptide and modulator of NaV1.6/NaV1.7, lowering the activation threshold of voltage-gated sodium channels and causing pain.</p>Fórmula:C129H215N33O31S·xC2H4O2Forma y color:SolidPeso molecular:2756.35 (free base)Ethacizine hydrochloride
CAS:<p>Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity and can be used to study arrhythmias and myocardial infarction.</p>Fórmula:C22H28ClN3O3SPureza:98.08% - 98.08%Forma y color:SolidPeso molecular:449.99Dibucaine hydrochloride
CAS:<p>Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.</p>Fórmula:C20H30ClN3O2Pureza:99.66%Forma y color:White PowderPeso molecular:379.92Bulleyaconitine A
CAS:<p>Bulleyaconitine A, an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.</p>Fórmula:C35H49NO9Pureza:99.56% - 99.76%Forma y color:SolidPeso molecular:627.76AM-2099
CAS:<p>AM-2099 is a selective voltage-gated sodium channel Nav1.7 inhibitor used in pain research.</p>Fórmula:C19H13F3N4O3S2Forma y color:SolidPeso molecular:466.46PF-04856264
CAS:<p>PF-04856264 is a Nav1.7 blocker.,modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain analgesic.</p>Fórmula:C20H15N5O3S2Pureza:97.43%Forma y color:SolidPeso molecular:437.5Mepivacaine
CAS:<p>Mepivacaine (Carbocaine) is an amide local anesthetic, blocking sodium channels for nerve blocks and epidurals.</p>Fórmula:C15H22N2OPureza:99.35%Forma y color:SolidPeso molecular:246.35Raxatrigine
CAS:<p>Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.</p>Fórmula:C18H19FN2O2Pureza:98% - 99.43%Forma y color:SolidPeso molecular:314.35DS-1971a
CAS:<p>DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.</p>Fórmula:C20H21ClFN5O3SPureza:99.66%Forma y color:SolidPeso molecular:465.93A-803467
CAS:<p>A-803467 is a selective NaV1.8 channel blocker.</p>Fórmula:C19H16ClNO4Pureza:96.94% - 98%Forma y color:SolidPeso molecular:357.79Flecainide hydrochloride
CAS:<p>Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.</p>Fórmula:C17H21ClF6N2O3Pureza:97.79%Forma y color:SolidPeso molecular:450.81Ropivacaine hydrochloride monohydrate
CAS:<p>Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.</p>Fórmula:C17H29ClN2O2Pureza:99.94% - 99.95%Forma y color:White SolidPeso molecular:328.88Fosphenytoin disodium
CAS:<p>Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker</p>Fórmula:C16H13N2Na2O6PPureza:99.97%Forma y color:White Crystalline PowderPeso molecular:406.24Metergoline
CAS:<p>Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist.</p>Fórmula:C25H29N3O2Pureza:99.83% - 99.97%Forma y color:SolidPeso molecular:403.52Rimeporide
CAS:<p>Rimeporide (EMD-87580) (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.</p>Fórmula:C11H15N3O5S2Pureza:97.66%Forma y color:SolidPeso molecular:333.38λ-Cyhalothrin
CAS:<p>λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group.</p>Fórmula:C23H19ClF3NO3Pureza:99.76%Forma y color:SolidPeso molecular:449.85Flecainide acetate
CAS:<p>Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).</p>Fórmula:C19H24F6N2O5Pureza:99.42%Forma y color:SolidPeso molecular:474.39Nicainoprol
CAS:<p>Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.</p>Fórmula:C21H27N3O3Pureza:99.54%Forma y color:SolidPeso molecular:369.46Pilsicainide HCl
CAS:<p>Pilsicainide HCl (SUN 1165) is a pure sodium channel blocker</p>Fórmula:C17H25ClN2OPureza:99.01% - 99.80%Forma y color:SolidPeso molecular:308.85
