Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Se han encontrado 273 productos para "Canal de sodio".
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Ceratotoxin-1
Ceratotoxin-1 (CcoTx1) is a peptide toxin that functions as an inhibitor of various voltage-gated sodium channel subtypes.Fórmula:C172H256N52O50S6Pureza:98%Forma y color:SolidPeso molecular:4044.58Analgesic agent-2
Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the humanFórmula:C21H21ClF2N4O2Pureza:98%Forma y color:SolidPeso molecular:434.87GX 201
CAS:GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.Fórmula:C25H27ClF4N2O4SPureza:99.81%Forma y color:White SolidPeso molecular:563GrTx1
GrTx1, a peptide toxin derived from Grammostola rosea spider venom, selectively inhibits sodium channels Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7,Fórmula:C159H243N45O41S8Pureza:98%Forma y color:SolidPeso molecular:3697.43Nav1.7-IN-18
Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).Fórmula:C30H33Cl2F2NO4Forma y color:SolidPeso molecular:580.49CL-424032
CAS:CL-424032 is a defined pyrazolo[5-a]pyrimidine derivative that functions as a potent sodium channel inhibitor, effectively blocking sodium ion flux across cellular membranes. CL-424032 is extensively utilized in pharmacology and drug discovery research to investigate sodium channel–dependent excitability, signal propagation, and therapeutic modulation of ion channel activity.Fórmula:C12H7F3N4O2Pureza:99.90%Forma y color:Yellow SolidPeso molecular:296.21ETD001
CAS:ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.Fórmula:C41H57F6N9O16Forma y color:SolidPeso molecular:1045.93Myomodulin
CAS:Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A theFórmula:C36H67N11O8S2Pureza:98%Forma y color:SolidPeso molecular:846.12Zoniporide hydrochloride
CAS:Zoniporide hydrochloride: selective NHE-1 inhibitor, IC50 14 nM, >150x selectivity over other NHEs, inhibits platelet swelling (IC50 59 nM).Fórmula:C17H17ClN6OPureza:99.68%Forma y color:White SolidPeso molecular:356.815-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Fórmula:C13H28OPureza:97.87%Forma y color:SolidPeso molecular:200.36GpTx-1
CAS:GpTx-1 exhibits potent selectivity as a NaV1.7 antagonist, demonstrating an inhibition concentration (IC50) of 10 nM [1].Fórmula:C176H271N53O45S7Pureza:98%Forma y color:SolidPeso molecular:4073.82Phlotoxin-1 TFA
Phlotoxin-1 (PhlTx1) is a 34-amino acid polypeptide with three disulfide bonds. It is derived from spiders of the Phlogiellus genus. Phlotoxin-1 acts as an antinociceptive agent by inhibiting the NaV1.7 channel.Forma y color:Odour Solidδ-Theraphotoxin-Hm1b
δ-Theraphotoxin-Hm1b, a 42-amino acid peptide derived from the Togo starburst tarantula (Heteroscodra maculata) venom, selectively inhibits the inactivation ofFórmula:C169H241N45O50S6Pureza:98%Forma y color:SolidPeso molecular:3895.38µ-Conotoxin GIIIB
CAS:μ-Conotoxin GIIIB, a 22-residue polypeptide derived from the venom of the piscivorous cone snail Conus geographus, serves as an inhibitor of the Na V 1.4Fórmula:C101H175N39O30S7Pureza:98%Forma y color:SolidPeso molecular:2640.17LTGO-33
CAS:LTGO-33 is a voltage-gated sodium channel NaV1.8 inhibitor that inhibits NaV1.8, NaV1.1-NaV1.7, and NaV1.9.Fórmula:C21H17F4N3O3SPureza:97.6%Forma y color:White SolidPeso molecular:467.44Nav1.2-IN-2
CAS:Nav1.2-IN-2 is a Nav1.2 inhibitor, IC₅₀=0.18 μM for inactivated Nav1.2, inhibits Veratridine-induced calcium influx, epilepsy.Fórmula:C17H26N2O4Pureza:99.97%Forma y color:White SolidPeso molecular:322.4Sodium Channel inhibitor 5
Sodium Channel inhibitor5 (compound 7d) is a potent sodium channel inhibitor with an IC50 of 2.7 μM, playing a significant role in antiarrhythmic research.Fórmula:C24H23F3N4O2Forma y color:SolidPeso molecular:456.17731Sodium Channel Targeted Library
A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;Forma y color:Odour SolidRef: TM-L7400
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarIon Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;Forma y color:Odour SolidRef: TM-L2300
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarProTx II
CAS:Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.Fórmula:C168H250N46O41S8Pureza:98%Forma y color:SolidPeso molecular:3826.59Mambalgin 1
CAS:ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.Fórmula:C272H429N85O84S10Pureza:98%Forma y color:SolidPeso molecular:6554.51APETx2
CAS:ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.Fórmula:C196H280N54O61S6Pureza:98%Forma y color:SolidPeso molecular:4561.061-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS:1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.Fórmula:C6H8N2OPureza:99.92%Forma y color:SolidPeso molecular:124.14PF-06456384 trihydrochloride
CAS:PF-06456384 trihydrochloride is a selective NaV1.7 inhibitor acting through protein-ligand binding. intravenous infusion and pain research.Fórmula:C35H35Cl3F3N7O3S2Pureza:99.16%Forma y color:White SolidPeso molecular:829.18µ-Conotoxin BuIIIA
μ-Conotoxin BuIIIA (Mu-Conotoxin BuIIIA), a toxin derived from Cone snail venom, functions as a voltage-gated sodium channel (VGSC) blocker.Fórmula:C106H172N44O31S6Pureza:98%Forma y color:SolidPeso molecular:2751.17Pe1b
Pe1b (μ-TrTx-Pe1b) is a selective inhibitor of the NaV1.7 channel, exhibiting an inhibitory concentration 50 (IC50) value of 167 nanomolar (nM) [1].Fórmula:C175H237N47O49S6Pureza:98%Forma y color:SolidPeso molecular:3975.43SLC26A3-IN-2
CAS:Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.Fórmula:C19H13ClN2O2SPureza:99.86%Forma y color:White SolidPeso molecular:368.84Mepivacaine hydrochloride
CAS:Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.Fórmula:C15H22N2O·HClPureza:99.80% - 99.96%Forma y color:White Or Off White Crystalline PowderPeso molecular:282.81Anthopleurin-C
Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide exhibiting a potent positive inotropic effect [1].Fórmula:C210H316N62O61S6Pureza:98%Forma y color:SolidPeso molecular:4877.52Zandatrigine
CAS:Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can be used in studies about nervous system pathologies of epilepsyFórmula:C22H25FN4O2S2Pureza:99.98%Forma y color:SolidPeso molecular:460.59Ref: TM-T39630
1mg111,00€2mg164,00€1mL*10mM (DMSO)264,00€5mg268,00€10mg439,00€25mg707,00€50mg1.009,00€100mg1.333,00€Mambalgin-3
Mambalgin-3, an acid-sensitive ion channel 1 (ASIC1) inhibitor, has potential applications in analgesia research [1].Fórmula:C274H433N85O83S10Pureza:98%Forma y color:SolidPeso molecular:6566.54GpTx-1 TFA
GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.Forma y color:Odour SolidPoneratoxin acetate
Poneratoxin acetate is a neurotoxic peptide and modulator of NaV1.6/NaV1.7, lowering the activation threshold of voltage-gated sodium channels and causing pain.Fórmula:C129H215N33O31S·xC2H4O2Forma y color:SolidPeso molecular:2756.35 (free base)PF-04856264
CAS:PF-04856264 is a Nav1.7 blocker.,modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain analgesic.Fórmula:C20H15N5O3S2Pureza:97.43%Forma y color:White SolidPeso molecular:437.5Ref: TM-T33943
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg170,00€25mg340,00€50mg532,00€100mg893,00€Clopamide (Standard)
CAS:Clopamide (Standard) is the standard substance of Clopamide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.Fórmula:C14H20ClN3O3SPeso molecular:345.84Triamterene-D5
CAS:Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic.Fórmula:C12H11N7Pureza:98%Forma y color:SolidPeso molecular:258.29Mexiletine-D6 hydrochloride
CAS:Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.Fórmula:C11H18ClNOPureza:98%Forma y color:SolidPeso molecular:221.7610,11-Dihydro-10-hydroxycarbamazepine-D4
CAS:10,11-Dihydro-10-hydroxycarbamazepine-d4 is a deuterated compound of 10,11-Dihydro-10-hydroxycarbamazepine.Fórmula:C15H10D4N2O2Forma y color:SolidPeso molecular:258.313,3-Diethylthiacarbocyanine iodide
CAS:3, 3-diethylthiacarbocyanine iodide is a cyanine dye. Can be used for photochemical methods.Fórmula:C21H21IN2S2Pureza:99.79%Forma y color:SolidPeso molecular:492.44Dibucaine hydrochloride
CAS:Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.Fórmula:C20H30ClN3O2Pureza:99.66%Forma y color:White PowderPeso molecular:379.92Mepivacaine
CAS:Mepivacaine (Carbocaine) is an amide local anesthetic, blocking sodium channels for nerve blocks and epidurals.Fórmula:C15H22N2OPureza:99.86%Forma y color:White SolidPeso molecular:246.35Bulleyaconitine A
CAS:Bulleyaconitine A, an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.Fórmula:C35H49NO9Pureza:99.56% - 99.76%Forma y color:White SolidPeso molecular:627.76AM-2099
CAS:AM-2099 is a selective voltage-gated sodium channel Nav1.7 inhibitor used in pain research.Fórmula:C19H13F3N4O3S2Forma y color:SolidPeso molecular:466.46Ethacizine hydrochloride
CAS:Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity and can be used to study arrhythmias and myocardial infarction.Fórmula:C22H28ClN3O3SPureza:98.08% - 98.08%Forma y color:SolidPeso molecular:449.99BI-9627
CAS:BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) (EC50: 31 nM).Fórmula:C16H19F3N4O2Pureza:99.77%Forma y color:White SolidPeso molecular:356.34PF-05186462
CAS:PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.Fórmula:C19H10ClF4N5O3S2Pureza:99.10% - 99.37%Forma y color:Yellow SolidPeso molecular:531.89β-Pompilidotoxin Acetate
β-Pompilidotoxin Acetate is a wasp venom peptide.Fórmula:C73H128N22O19Pureza:98.64%Forma y color:SolidPeso molecular:1617.93Ref: TM-T21769L
2mg44,00€5mg63,00€10mg94,00€1mL*10mM (DMSO)129,00€25mg145,00€50mg210,00€100mg298,00€200mg419,00€Dimethyl lithospermate B
CAS:Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.Fórmula:C38H34O16Pureza:97.18% - 99.62%Forma y color:Yellow SolidPeso molecular:746.67Ref: TM-T8299
1mg137,00€2mg202,00€5mg356,00€1mL*10mM (DMSO)502,00€10mg522,00€25mg820,00€50mg1.099,00€100mg1.485,00€200mg2.008,00€Tenapanor
CAS:Tenapanor (RDX 5791), an NHE3 inhibitor, regulates sodium in the gut and kidney with a strong preclinical safety record and minimal side effects.Fórmula:C50H66Cl4N8O10S2Pureza:99.49% - 99.85%Forma y color:White SolidPeso molecular:1145.05Metergoline
CAS:Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist.Fórmula:C25H29N3O2Pureza:99.83% - 99.97%Forma y color:SolidPeso molecular:403.52
