Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Se han encontrado 273 productos para "Canal de sodio".
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DS-1971a
CAS:DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.Fórmula:C20H21ClFN5O3SPureza:99.66%Forma y color:White SolidPeso molecular:465.93Cariporide
CAS:Cariporide (HOE-642), an NHE1 inhibitor, reduces human platelet degranulation, platelet-leukocyte aggregates, and GPIIb/IIIa activation.Fórmula:C12H17N3O3SPureza:95.4% - 99.88%Forma y color:SolidPeso molecular:283.35Rimeporide hydrochloride
CAS:Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.Fórmula:C11H16ClN3O5S2Pureza:99.82%Forma y color:SolidPeso molecular:369.84Licarbazepine
CAS:Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partialFórmula:C15H14N2O2Pureza:99.11%Forma y color:White SolidPeso molecular:254.28Nav1.8-IN-1
CAS:Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8Fórmula:C20H15ClF3N3O2Pureza:97.59%Forma y color:White SolidPeso molecular:421.8Ref: TM-T8579
1mg58,00€5mg116,00€1mL*10mM (DMSO)136,00€10mg172,00€25mg281,00€50mg396,00€100mg537,00€200mg712,00€QX-222 chloride
CAS:QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.Fórmula:C13H21ClN2OPureza:97.37%Forma y color:SolidPeso molecular:256.77Carbamazepine
CAS:Carbamazepine: a tricyclic with anticonvulsant and analgesic effects, treats trigeminal neuralgia.Fórmula:C15H12N2OPureza:99.78% - 99.79%Forma y color:White SolidPeso molecular:236.27λ-Cyhalothrin
CAS:λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group.Fórmula:C23H19ClF3NO3Pureza:99.76%Forma y color:SolidPeso molecular:449.85Rimeporide
CAS:Rimeporide (EMD-87580) (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.Fórmula:C11H15N3O5S2Pureza:97.66%Forma y color:SolidPeso molecular:333.38Ref: TM-T5319
1mg46,00€2mg62,00€5mg90,00€1mL*10mM (DMSO)108,00€10mg166,00€25mg358,00€50mg523,00€100mg747,00€Flecainide hydrochloride
CAS:Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.Fórmula:C17H21ClF6N2O3Pureza:97.79%Forma y color:SolidPeso molecular:450.81Raxatrigine
CAS:Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.Fórmula:C18H19FN2O2Pureza:98% - 99.43%Forma y color:SolidPeso molecular:314.35N-Me-aminopyrimidinone9
CAS:N-Me-aminopyrimidinone9 is a sodium channel antagonistFórmula:C16H21N3OSPureza:99.21%Forma y color:White SolidPeso molecular:303.42Ref: TM-T8444
1mg58,00€5mg116,00€1mL*10mM (DMSO)116,00€10mg172,00€25mg281,00€50mg396,00€100mg537,00€200mg712,00€Levobupivacaine
CAS:Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.Fórmula:C18H28N2OPureza:99.72%Forma y color:SolidPeso molecular:288.43Ref: TM-T1787
5mg46,00€1mL*10mM (DMSO)47,00€10mg59,00€25mg87,00€50mg129,00€100mg178,00€200mg268,00€500mg460,00€Propafenone hydrochloride
CAS:Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial.Fórmula:C21H27NO3·HClPureza:99.66% - 99.67%Forma y color:White SolidPeso molecular:377.9Benzocaine xHCl(94-09-7(free base))
Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).Fórmula:C9H11NO2·xHClPureza:99.37%Forma y color:White SolidPeso molecular:N/AVX-150
CAS:VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).Fórmula:C21H17F4N2O7PPureza:97.58%Forma y color:SolidPeso molecular:516.34Ref: TM-T9683
1mg63,00€5mg137,00€1mL*10mM (DMSO)156,00€10mg222,00€25mg447,00€50mg715,00€100mg1.144,00€PF-01247324
CAS:PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).Fórmula:C13H10Cl3N3OPureza:99.22%Forma y color:SolidPeso molecular:330.6PF 05089771
CAS:PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV.Fórmula:C18H12Cl2FN5O3S2Pureza:99.03% - 99.42%Forma y color:Yellow SolidPeso molecular:500.35PF-05186462
CAS:PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.Fórmula:C19H10ClF4N5O3S2Pureza:99.10% - 99.37%Forma y color:Yellow SolidPeso molecular:531.89Ralfinamide mesylate
CAS:Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker.Fórmula:C18H23FN2O5SPureza:99.83%Forma y color:SolidPeso molecular:398.45ICA-121431
CAS:ICA-121431: a potent Nav1.7 inhibitor (IC50=19 nM for rat), minimal effect on human Nav1.5/Nav1.7.Fórmula:C23H19N3O3S2Pureza:98.06%Forma y color:White SolidPeso molecular:449.55(+)-Kavain
CAS:(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.Fórmula:C14H14O3Pureza:97% - ≥95%Forma y color:SolidPeso molecular:230.26Benzamil
CAS:Benzamil blocks ENaC, inhibiting sodium transport (IC50=4 nM) and binds with Kd=5 nM to bovine kidney membranes.Fórmula:C13H14ClN7OPureza:99.79%Forma y color:SolidPeso molecular:319.7520(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Fórmula:C42H72O13Pureza:98.11% - 99.93%Forma y color:SolidPeso molecular:785.01Dronedarone
CAS:Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.Fórmula:C31H44N2O5SPureza:98.85% - 99.99%Forma y color:Transparent ViscousPeso molecular:556.76Evenamide
CAS:Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.Fórmula:C16H26N2O2Pureza:96.74% - 99.15%Forma y color:SolidPeso molecular:278.39Ref: TM-T15260
1mg39,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg120,00€25mg236,00€50mg378,00€100mg612,00€200mg850,00€Metaflumizone
CAS:Metaflumizone (BAS-320I) is a sodium channel blocker insecticide.Fórmula:C24H16F6N4O2Pureza:98.73%Forma y color:SolidPeso molecular:506.40Cyfluthrin
CAS:Producto controladoCyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pestsFórmula:C22H18Cl2FNO3Pureza:99.76%Forma y color:White SolidPeso molecular:434.29A-803467
CAS:A-803467 is a selective NaV1.8 channel blocker.Fórmula:C19H16ClNO4Pureza:96.94% - 98%Forma y color:SolidPeso molecular:357.79Metergoline
CAS:Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist.Fórmula:C25H29N3O2Pureza:99.83% - 99.97%Forma y color:SolidPeso molecular:403.52Tenapanor
CAS:Tenapanor (RDX 5791), an NHE3 inhibitor, regulates sodium in the gut and kidney with a strong preclinical safety record and minimal side effects.Fórmula:C50H66Cl4N8O10S2Pureza:99.49% - 99.85%Forma y color:White SolidPeso molecular:1145.05Dimethyl lithospermate B
CAS:Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.Fórmula:C38H34O16Pureza:97.18% - 99.62%Forma y color:Yellow SolidPeso molecular:746.67Ref: TM-T8299
1mg137,00€2mg202,00€5mg356,00€1mL*10mM (DMSO)502,00€10mg522,00€25mg820,00€50mg1.099,00€100mg1.485,00€200mg2.008,00€Eslicarbazepine Acetate
CAS:Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.Fórmula:C17H16N2O3Pureza:99.58% - >99.99%Forma y color:White SolidPeso molecular:296.32Ref: TM-T3285
5mg35,00€10mg52,00€1mL*10mM (DMSO)52,00€25mg87,00€50mg117,00€100mg161,00€200mg254,00€500mg371,00€β-Pompilidotoxin Acetate
β-Pompilidotoxin Acetate is a wasp venom peptide.Fórmula:C73H128N22O19Pureza:98.64%Forma y color:SolidPeso molecular:1617.93Ref: TM-T21769L
2mg44,00€5mg63,00€10mg94,00€1mL*10mM (DMSO)129,00€25mg145,00€50mg210,00€100mg298,00€200mg419,00€Nicainoprol
CAS:Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.Fórmula:C21H27N3O3Pureza:99.54%Forma y color:White SolidPeso molecular:369.46Ref: TM-T4539
1mg133,00€5mg326,00€1mL*10mM (DMSO)333,00€10mg485,00€25mg770,00€50mg1.035,00€100mg1.395,00€Sodium ionophore III
CAS:Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood.Fórmula:C34H52N2O4Pureza:99.51% - 99.83%Forma y color:SolidPeso molecular:552.79BI 01383298
CAS:BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).Fórmula:C19H19Cl2FN2O3SPureza:99.71%Forma y color:White SolidPeso molecular:445.34GS967
CAS:GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).Fórmula:C14H7F6N3OPureza:98% - >99.99%Forma y color:Yellow SolidPeso molecular:347.22Ref: TM-T2049
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg74,00€25mg150,00€50mg269,00€100mg470,00€200mg680,00€500mg1.054,00€Pilsicainide HCl
CAS:Pilsicainide HCl (SUN 1165) is a pure sodium channel blockerFórmula:C17H25ClN2OPureza:99.01% - 99.80%Forma y color:SolidPeso molecular:308.85AZ194
CAS:CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.Fórmula:C34H31F2N3O3Pureza:99.61%Forma y color:SolidPeso molecular:567.62Ref: TM-T9461
1mg77,00€5mg166,00€1mL*10mM (DMSO)178,00€10mg260,00€25mg485,00€50mg700,00€100mg982,00€500mg1.963,00€RY785
CAS:RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.Fórmula:C21H20N4O2SPureza:99.78%Forma y color:White SolidPeso molecular:392.47Ref: TM-T12786
1mg49,00€1mL*10mM (DMSO)118,00€5mg137,00€10mg222,00€25mg378,00€50mg530,00€100mg745,00€200mg1.035,00€6-Benzoylheteratisine
CAS:6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid.Fórmula:C29H37NO6Pureza:99.87%Forma y color:SolidPeso molecular:495.61Benzonatate
CAS:Benzonatate is an antagonist of sodium channel protein.Fórmula:C30H53NO11Pureza:99.92%Forma y color:SolidPeso molecular:603.74PF-06869206
CAS:PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).Fórmula:C15H14ClF3N4O2Pureza:99.79% - 99.88%Forma y color:White SolidPeso molecular:374.75Levobupivacaine hydrochloride
CAS:Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.Fórmula:C18H28N2O·HClPureza:99.74%Forma y color:SolidPeso molecular:324.893-Deoxyaconitine
CAS:3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thusFórmula:C34H47NO10Pureza:98.31% - 99.94%Forma y color:White SolidPeso molecular:629.74Ralfinamide
CAS:Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.Fórmula:C17H19FN2O2Pureza:99.41%Forma y color:White SolidPeso molecular:302.34Oxethazaine
CAS:Producto controladoApplications A potent local anesthetic that is active even in acidic conditions. It is used (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis.
References Detrain, M. et al.: Acta. Gastro-Enterol. Belg., 28, 360 (1965); Barbezat, G.O. et al.: Scand. J. Gastroenterol., 13, 321 (1978); Masuda, Y. et al.: Biochem. Pharmacol., 64, 677 (2002);Fórmula:C28H41N3O3Forma y color:NeatPeso molecular:467.64Riluzole
CAS:Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.Fórmula:C8H5F3N2OSPureza:99.71% - 99.88%Forma y color:SolidPeso molecular:234.2Benzocaine N-Glucoside (a/b mixture)
CAS:Producto controladoStability Hygroscopic
Applications The N-Glucoside of Benzocaine (B202970) with anesthetic activity. A potential sun-screening agent.
References Rybczynska, B. et al.: Parfum. Kosm., 48, 125 (1967); Nikolin, A. et al.: Glas. Hemi. Tehnol. Bosne Herceg., 16, 93 (1968);Fórmula:C15H21NO7Forma y color:NeatPeso molecular:327.33
