OAT
Los transportadores de aniones orgánicos son una familia de proteínas de membrana que median la captación y excreción de varios aniones orgánicos endógenos y exógenos, incluyendo medicamentos, toxinas y subproductos metabólicos. Los OAT se expresan principalmente en los riñones y el hígado, donde juegan un papel crucial en la desintoxicación y la eliminación de medicamentos. La disfunción de la función de los OAT puede llevar a toxicidad por medicamentos y trastornos renales. En CymitQuimica, ofrecemos una variedad de moduladores de OAT para apoyar su investigación en farmacología, toxicología y función renal.
Se han encontrado 32 productos de "OAT"
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URAT1&XO inhibitor 2
CAS:Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM forFórmula:C14H12BrNO3Pureza:98%Forma y color:SolidPeso molecular:322.15Lingdolinurad
CAS:Lingdolinurad is a uric acid transporter protein inhibitor targeting hURAT1 for the study of hyperuricemia or gout.Fórmula:C17H12BrN3O2Pureza:96.26%Forma y color:SolidPeso molecular:370.2Ref: TM-T79854
1mg109,00€5mg261,00€1mL*10mM (DMSO)266,00€10mg374,00€25mg583,00€50mg803,00€100mg1.063,00€200mg1.431,00€URAT1 inhibitor 6
CAS:URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone,Fórmula:C9H7BrN3NaO2S2Forma y color:SolidPeso molecular:356.2URAT1 inhibitor 8
CAS:URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM.Fórmula:C19H13ClFN3O4SForma y color:SolidPeso molecular:433.84URAT1 inhibitor 1
CAS:URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout.Fórmula:C19H15Br2N5O2S2Pureza:98%Forma y color:SolidPeso molecular:569.29TRPV1 antagonist 10
CAS:TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.Fórmula:C16H14N2O5Forma y color:SolidPeso molecular:314.293URAT1 inhibitor 13
CAS:URAT1 inhibitor13 (compound 22k) is a potent inhibitor of URAT1, useful for research related to gout.Fórmula:C18H14Cl2N2O2Forma y color:SolidPeso molecular:361.22KPH2f
CAS:KPH2f: dual URAT1/GLUT9 inhibitor, orally active, IC50: 0.24μM (URAT1), 9.37μM (GLUT9), minimal OAT1/ABCG2 impact.Fórmula:C24H16N3NaO2SForma y color:SolidPeso molecular:433.46hURAT1 inhibitor 2
CAS:hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.Fórmula:C17H11Br2FO3Forma y color:SolidPeso molecular:442.074URAT1 inhibitor 3
URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.Fórmula:C14H8Cl2N2O2Forma y color:SolidPeso molecular:307.13URAT1 inhibitor 2
URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.Fórmula:C21H18BrN3O2SForma y color:SolidPeso molecular:456.36URAT1-IN-14
CAS:URAT1-IN-14 is a potent and orally active inhibitor of uric acid transporter 1 (URAT1). It demonstrates an IC50 value of 0.72 μM for inhibiting human URAT1 in HEK293 cells and exhibits low cytotoxicity in Hep-G2 cells. URAT1-IN-14 reduces uric acid levels in a hyperuricemia mouse model and is applicable in research on hyperuricemia and gout.Fórmula:C19H19NO3SForma y color:SolidPeso molecular:341.42
